Clinical and cost effectiveness of eight disinfection methods for terminal disinfection of hospital isolation rooms contaminated with Clostridium difficile 027

Doan, Lan Thi Phuong; Forrest, Helen; Fakis, Apostolos; Craig, Joyce; Claxton, Lindsay; Khare, Milind

doi:10.1016/j.jhin.2012.06.014

Cited by 52 publications

(40 citation statements)

References 24 publications

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“…In a comparison of eight methods for terminal disinfection aimed specifically at the elimination of C. difficile, Doan et al (2012) concluded that the release of HPV was the most effective method, but was also the most expensive, confirming the earlier statements of Vonberg et al (2008) and Davies et al (2011). Doan et al (2012) claimed that disinfection with a chlorine-releasing agent, although marginally less effective than HPV, was considerably cheaper and therefore should be considered the method of choice.…”

Section: Discussionmentioning

confidence: 54%

“…Doan et al (2012) claimed that disinfection with a chlorine-releasing agent, although marginally less effective than HPV, was considerably cheaper and therefore should be considered the method of choice. However, these authors did not specify precisely how the chlorine-releasing agent was applied to surfaces and whether the researchers themselves or cleaning staff conducted the decontamination with these agents.…”

Section: Discussionmentioning

confidence: 99%

“…Some systems use forced convection following release of the vapor=spray, which assists in the distribution of the vapor within the room, whereas others do not, relying solely on diffusion. There appears to be general agreement that the HPV decontamination method is effective, but criticism has been directed at the lengthy treatment cycle times (Vonberg et al, 2008;Davies et al, 2011;Maillard, 2011;Doan et al, 2012). Not only must the HPV be released and be allowed to act, but following the disinfection phase its concentration must fall to a safe level (typically 1 ppm) before healthcare personnel and patients can be readmitted.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An Investigation into the Inactivation Kinetics of Hydrogen Peroxide Vapor Against Clostridium difficile Endospores

Malik

Shaw

Shama

et al. 2016

Chemical Engineering Communications

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C. difficile spores are resistant to routine cleaning agents and are able to survive on inanimate surfaces for long periods of time. There is increasing evidence of the importance of the clinical environment as a reservoir for pathogenic agents and as a potential source of healthcare-associated infections (HCAIs). In this context, to reduce the risk of cross-transmission, terminal disinfection of hospital wards and isolation rooms using hydrogen peroxide vapor (HPV) is attracting attention. Spores of C. difficile (ribotype 027) were exposed to constant concentrations of HPV ranging between 11 and 92 mg m À3 (ppm) for a range of exposure times in a specially designed chamber. The inactivation data thus obtained was fitted using the modified Chick-Watson inactivation model to obtain decimal reduction values (D values). D values ranged from 23 to 1.3 min at HPV concentrations of 11 and 92 ppm, respectively. We present a simple mathematical model based on the inactivation kinetic data obtained here to estimate the efficacy of commercial HPV processes used in healthcare environmental decontamination. C. difficile spores showed linear inactivation kinetics at steady HPV concentrations ranging between 10 and 90 ppm. The data obtained here was used to provide estimates of the inactivation efficacy of commercial HPV process cycles, which employ unsteady HPV concentrations during the decontamination process.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Investigation into the Inactivation Kinetics of Hydrogen Peroxide Vapor Against Clostridium difficile Endospores

Malik

Shaw

Shama

et al. 2016

Chemical Engineering Communications

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“…We also showed a disinfection process for specific microorganisms, where protocols aimed at minimizing or even eliminating bacteria such as Clostridium difficile [17,23], methicillin-resistant Staphylococcus aureus [17][18][19]25] vancomycin-resistant Enterococcus [17,22] of which are often associated with hospital infections, with increased environmental resistance, have a more reserved prognosis and a difficult treatment [2,3].…”

Section: Discussionmentioning

confidence: 99%

Disinfectant Use in the Hospital Environment for Microorganisms Control

Oliveira¹,

Araújo²,

Garcia³

et al. 2017

J Bacteriol Parasitol

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Studies indicate that the hospital has an important role in transmission of various pathogens. To minimize the spread of these microorganisms in hospitals, they proposed various forms of disinfection, however diversity and effectiveness of these methods are varied. Thus, this study aimed to understand the associations and approaches that have been reported in recent years on microorganisms control by disinfectants in the hospital environment, thus enabling the search for new strategies and/or implementation of conducts already performed in other hospitals. In this article they performed a systematic review on the topic, in accordance with the preferred reporting items for systematic reviews and meta-analyzes-PRISMA. Articles were selected published between the years 2012-2016 present in the PubMed database. The data demonstrate that reviews many conventional methods may be flawed (10%), or may not be able to reduce the number of microorganisms (30%). The most frequently related microorganisms were Clostridium difficile (20%), methicillin-resistant Staphylococcus aureus (40%), or Enterococcus resistant to vancomycin (20%). There was no evidence statistical differences for a tendency to exchange the conventional methods, however the management was highlighted by 50% of the disinfection process. But our approach has enabled better understanding of mechanisms linked to environmental disinfection process of pathogenic microorganisms, thus pointing to coherent strategies in disinfection processes, which have benefits with the reduction of major causative agents of nosocomial infections and thus with decreasing nosocomial diseases.

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“…Thus, satisfactory results have been obtained in the treatment of diabetic foot (Wainstein et al, 2011), hepatitis (Zaky et al, 2011), cancer (Schulz et al, 2008), coronary heart disease (Martínez-Sánchez et al, 2012), atherosclerosis (Delgado-Roche et al, 2013), as a disinfecting agent in microorganisms causing nosocomial infections (Doan et al, 2012;Zoutman et al, 2011), and others. When a gas is used for therapeutic purposes, often their kinetic behavior and their distribution in biological systems is not known, leading to unsatisfactory results when clinical application.…”

Section: Introductionmentioning

confidence: 99%

Dissolved ozone in biological fluid monitored by optical device operating in the red-infrared region

Carvalho

Melo

Lima

et al. 2014

Rev. Bras. Eng. Bioméd.

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Introduction: When a gas is used for therapy, often the kinetic behavior and their distribution in biological systems is not known, leading to unsatisfactory results for clinical application. The use of ozone in living organisms has been scientifically released worldwide under the name of ozone therapy. The efficacy of this technique is determined primarily by the diffusion of gas within the tissues or fluids and which determines their action in the entire target region. We propose the development of technique to monitoring the O 3 dissolved in the biological fluid using an optical device operating in the red-infrared region. Methods: The recombination of O 3 in O 2 enables the monitoring of the latter by the measurement of SpO 2 , and, based on this phenomenon, we propose to use an optical device operating in the red-infrared region to monitoring indirectly the diffusion of O 3 in fluids. The system was based on optomechanical arrangement using a capsule containing fluid that was ozonated or oxygenated during the process. A pulse oximeter is a noninvasive device used for continuously measure of SpO 2 resulting from the recombination of ozone. Results: The measurements of SpO 2 when subjected to ozone and oxygen, showed an increased rate of SpO 2 function of time for both cases reaching its peak in 80s and 160s, respectively. The experimental data concerning the SpO 2 saturation as a function of time can be fitted by the theoretical model, showing a good correlation between them. Conclusion: A technique was developed using an optical device operating in the red-infrared region to monitoring ozone dissolved in biological fluid, showing a simple and effective way to indirectly monitoring the presence of ozone in fluids.

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Clinical and cost effectiveness of eight disinfection methods for terminal disinfection of hospital isolation rooms contaminated with Clostridium difficile 027

Cited by 52 publications

References 24 publications

An Investigation into the Inactivation Kinetics of Hydrogen Peroxide Vapor Against Clostridium difficile Endospores

An Investigation into the Inactivation Kinetics of Hydrogen Peroxide Vapor Against Clostridium difficile Endospores

Disinfectant Use in the Hospital Environment for Microorganisms Control

Dissolved ozone in biological fluid monitored by optical device operating in the red-infrared region

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