Clinical and Demographic Features of Pediatric-Onset Behçet’s Disease and Evaluation of Optical Coherence Tomography Findings

Balbaba, Mehmet; Ulaş, Fatih; Postacı, Sevinç Arzu; Çeliker, Ülkü; Gürgöze, Metin Kaya

doi:10.1080/09273948.2019.1611875

Cited by 9 publications

(7 citation statements)

References 25 publications

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“…Classic ocular findings in BD include shifting hypopyon, vitritis, retinal vasculitis, and retinitis, but based on existing multimodal imaging studies of adults and children with BD, particular attention should be paid to changes in choroidal thickness and morphology. Balbaba et al 87 reported SD-OCT and FA findings in a series of 23 pediatric patients with BD and ocular involvement, and found subfoveal choroidal thickness to be significantly increased, which is corroborated by several reports in adults and felt to be related to choroidal effusion from the influx of inflammatory mediators during acute episodes. Ishikawa et al 88 illustrated similar findings in 23 eyes of 13 patients with BD using EDI-OCT; choroidal thickness correlated significantly with anterior, posterior, and total inflammation scores, and decreased following treatment of their patients with infliximab.…”

Section: Imaging In Pediatric Uveitissupporting

confidence: 60%

“…In terms of retinal findings, BD patients appear to demonstrate either equivalent or increased macular thickness due to edema during acute inflammation, and decreased macular thickness following resolution of inflammation. Balbaba et al 87 found no significant overall difference in retinal thickness between pediatric BD patients with or without ocular involvement, but did report two patients who presented with atrophic maculae and associated decrease in central retinal thickness. After excluding patients with macular edema, Coskun et al 89 reported decreased mean central macular thickness as well, again in patients with known macular atrophy on exam.…”

Section: Imaging In Pediatric Uveitismentioning

confidence: 91%

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Multimodal imaging in pediatric uveitis

et al. 2021

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Pediatric uveitis accounts for up to 10% of all uveitis cases, so special attention must be paid to ensure early diagnosis as well as treatment and follow-up of these young patients in order to decrease the risk of possible ocular complications and consequently vision loss. Multimodal imaging has been an effective and important adjunct in the diagnoses and management of uveitis, especially in children. Reviewed here are the currently utilized modalities, advances, as well as their applications in juvenile idiopathic arthritis–associated uveitis, pars planitis, retinal vasculitis, tubulointerstitial nephritis and uveitis syndrome, Behçet disease, Blau syndrome, and Vogt–Koyanagi–Harada syndrome.

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Section: Imaging In Pediatric Uveitissupporting

confidence: 60%

Section: Imaging In Pediatric Uveitismentioning

confidence: 91%

Multimodal imaging in pediatric uveitis

et al. 2021

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“…Since the choroid is a vascular layer, variations in its thickness can serve as a reliable indicator to assess the response to inflammation. Balbaba et al observed an increased subfoveal choroidal thickness in patients with jBD and ocular involvement, a finding already known from adult studies [ 51 , 52 ]. Also, children with atrophic maculae and associated decrease in CMT have been described [ 51 , 53 ].…”

Section: Discussionmentioning

confidence: 56%

Ocular Manifestations in Juvenile Behçet’s Disease: A Registry-Based Analysis from the AIDA Network

Gaggiano,

Tufan,

Guerriero

et al. 2024

Ophthalmol Ther

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Introduction This study aims to characterize ocular manifestations of juvenile Behçet’s disease (jBD). Methods This was a registry-based observational prospective study. All subjects with jBD from the Autoinflammatory Diseases Alliance (AIDA) Network BD Registry showing ocular manifestations before 18 years were enrolled. Results We included 27 of 1000 subjects enrolled in the registry (66.7% male patients, 45 affected eyes). The median (interquartile range [IQR]) age at ocular involvement was 14.2 (4.7) years. Uveitis affected 91.1% of eyes (anterior 11.1%, posterior 40.0%, panuveitis 40.0%), retinal vasculitis 37.8% and other manifestations 19.8%. Later onset ( p = 0.01) and male predominance ( p = 0.04) characterized posterior involvement. Ocular complications occurred in 51.1% of eyes. Patients with complications had earlier onset ( p < 0.01), more relapses ( p = 0.02) and more prolonged steroidal treatment ( p = 0.02). The mean (standard deviation [SD]) central macular thickness (CMT) at the enrolment and last visit was 302.2 (58.4) and 293.3 (78.2) μm, respectively. Fluorescein angiography was pathological in 63.2% of procedures, with a mean (SD) Angiography Scoring for Uveitis Working Group (ASUWOG) of 17.9 (15.5). At the last visit, ocular damage according to the BD Overall Damage Index (BODI) was documented in 73.3% of eyes. The final mean (SD) best corrected visual acuity (BCVA) logMAR was 0.17 (0.47) and blindness (BCVA logMAR < 1.00 or central visual field ≤ 10°) occurred in 15.6% of eyes. At multivariate regression analysis, human leukocyte antigen (HLA)-B51 + independently predicted a + 0.35 change in the final BCVA logMAR ( p = 0.01), while a higher BCVA logMAR at the first assessment (odds ratio [OR] 5.80; p = 0.02) independently predicted blindness. Conclusions The results of this study may be leveraged to guide clinical practice and future research on this rare sight-threatening condition. Supplementary Information The online version contains supplementary material available at 10.1007/s40123-024-00916-z.

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“…OCT can also detect cystoid macular edema in the pars planitis and intraretinal fluid, ERM and epiretinal membrane, intraretinal fluid and optic nerve edema in tubulointerstitial nephritis and uveitis (TINU) syndrome, as well as sub- and intraretinal fluid and choroidal undulation in Vokt–Koyanagi–Harada (VKH) disease [ 161 ]. Increased subfoveal choroidal thickness was also noted in Behçet disease [ 162 ].…”

Section: Oct and Octa In Inflammatory/uveitic Diseasesmentioning

confidence: 99%

Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases

et al. 2023

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Indirect ophthalmoscopy and handheld retinal imaging are the most common and traditional modalities for the evaluation and documentation of the pediatric fundus, especially for pre-verbal children. Optical coherence tomography (OCT) allows for in vivo visualization that resembles histology, and optical coherence tomography angiography (OCTA) allows for non-invasive depth-resolved imaging of the retinal vasculature. Both OCT and OCTA were extensively used and studied in adults, but not in children. The advent of prototype handheld OCT and OCTA have allowed for detailed imaging in younger infants and even neonates in the neonatal care intensive unit with retinopathy of prematurity (ROP). In this review, we discuss the use of OCTA and OCTA in various pediatric retinal diseases, including ROP, familial exudative vitreoretinopathy (FEVR), Coats disease and other less common diseases. For example, handheld portable OCT was shown to detect subclinical macular edema and incomplete foveal development in ROP, as well as subretinal exudation and fibrosis in Coats disease. Some challenges in the pediatric age group include the lack of a normative database and the difficulty in image registration for longitudinal comparison. We believe that technological improvements in the use of OCT and OCTA will improve our understanding and care of pediatric retina patients in the future.

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Clinical and Demographic Features of Pediatric-Onset Behçet’s Disease and Evaluation of Optical Coherence Tomography Findings

Cited by 9 publications

References 25 publications

Multimodal imaging in pediatric uveitis

Multimodal imaging in pediatric uveitis

Ocular Manifestations in Juvenile Behçet’s Disease: A Registry-Based Analysis from the AIDA Network

Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases

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