Literature on earthquake impact on hospital admissions is lacking, particularly in low-resource settings. Our aim was to study the pattern of admissions before and after the 2015 earthquake in a tertiary hospital in Nepal. We used routine hospital data from 9,596 admissions, and defined four periods: pre-earthquake (pre-EQ), acute (EQ1), post-acute (EQ2), and post-earthquake (post-EQ). We compared length of hospital stay (LOS) across the study periods using negative binomial regressions. We used logistic regressions to study changes in probability of admission for diagnostic categories, and Generalized Additive Models to model the difference in number of admissions compared to pre-EQ baseline. LOS was longer in EQ1 than during pre-EQ, in particular for injury-related admissions. In EQ1, the odds of injury admissions increased, while they decreased for the majority of other diagnoses, with the odds of pregnancy-related admissions remaining low until post-EQ. The number of admissions dropped in EQ1 and EQ2, and returned to pre-EQ trends in post-EQ, accumulating 381 admissions lost (CI: 206-556). Our findings suggest that hospital disaster plans must not only foresee injury management after earthquakes, but also ensure accessibility, in particular for pregnant women, and promote a quick return to normality to prevent additional negative health outcomes. Violent, sudden-onset disasters, such as hurricanes or earthquakes, cause considerable damage in communities, leading to widespread destruction 1. While deaths and direct injuries are immediate and expectable consequences of such disasters, drastic changes in the surrounding environment may have longer-term health effects 2-7. These disasters also heavily disturb health systems, which must provide healthcare in a context of sudden increase of health needs, radical change of priority conditions, infrastructural and material damage, and staff shortages 8. While most of the victims in need of care during and after a disaster are managed in an outpatient basis at emergency departments, a considerable amount of people will require hospitalization 9. However, there is inconsistent evidence on the impact on hospital admissions immediately after and in the months following violent, sudden-onset disasters 3,10-12. Earthquakes are the most destructive type of natural disaster, having killed nearly 720,000 people globally between 2000 and 2018. About two thirds of all events worldwide occurred in Asia, where earthquakes affect much more people than earthquakes in all the other continents 13. Rapid population growth, urbanization, poverty, and geological risks contribute to Asia's seismic vulnerability. Nepal is located on the boundaries of two colliding tectonic plates. On April 25 th 2015, an earthquake with a moment magnitude of 7.8 severely hit the country. The epicenter was in Gorkha district, and heavy infrastructural damage occurred in neighbouring regions, including in the capital city of Kathmandu located 76 km away. There were several aftershocks, the strongest occurri...