Clinical And Economic Burden Of Asthma And Chronic Obstructive Pulmonary Disease (Copd) In Poland: Estimated Impact Of Poor Inhalation Technique With Inhaled Corticosteroid And Long-Acting Beta Agonist Fixed-Dose Combinations

Bijos, Pawel; Kaczynski, J; Torvinen, Saku; Lenarczyk, Ewelina; Wrona, W; Plich, A; Lewis, Adam; Blackney, M.

doi:10.1016/j.jval.2015.09.1408

Cited by 2 publications

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“…Bijos modelled the impact of poor inhaler technique on healthcare resource use in Poland, and concluded that misuse of inhaled corticosteroid and long-acting beta agonist fixed-dose combinations resulted in an annual loss of 378 million PLN (€91.1 million) in direct costs and 20.4 million PLN (€4.9 million) in indirect productivity, costs across asthma and COPD [ 129 ].…”

Section: Resultsmentioning

confidence: 99%

Critical inhaler errors in asthma and COPD: a systematic review of impact on health outcomes

et al. 2018

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BackgroundInhaled drug delivery is the cornerstone treatment for asthma and chronic obstructive pulmonary disease (COPD). However, use of inhaler devices can be challenging, potentially leading to critical errors in handling that can significantly reduce drug delivery to the lungs and effectiveness of treatment.MethodsA systematic review was conducted to define ‘critical’ errors and their impact on health outcomes and resource use between 2004 and 2016, using key search terms for inhaler errors in asthma and COPD (Search-1) and associated health-economic and patient burden (Search-2).ResultsSearch-1 identified 62 manuscripts, 47 abstracts, and 5 conference proceedings (n = 114 total). Search-2 identified 9 studies. We observed 299 descriptions of critical error. Age, education status, previous inhaler instruction, comorbidities and socioeconomic status were associated with worse handling error frequency. A significant association was found between inhaler errors and poor disease outcomes (exacerbations), and greater health-economic burden.ConclusionsWe have shown wide variations in how critical errors are defined, and the evidence shows an important association between inhaler errors and worsened health outcomes. Given the negative impact diminished disease outcomes impose on resource use, our findings highlight the importance of achieving optimal inhaler technique, and a need for a consensus on defining critical and non-critical errors.Electronic supplementary materialThe online version of this article (10.1186/s12931-017-0710-y) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Critical inhaler errors in asthma and COPD: a systematic review of impact on health outcomes

et al. 2018

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Suboptimal Peak Inspiratory Flow and Critical Inhalation Errors are Associated with Higher COPD-Related Healthcare Costs

Leving¹,

Boven²,

Bosnic‐Anticevich³

et al. 2022

COPD

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Purpose To assess the relationship between suboptimal Peak Inspiratory Flow (sPIF), inhalation technique errors, and non-adherence, with Healthcare Resource Utilisation (HCRU) in Chronic Obstructive Pulmonary Disease (COPD) patients receiving maintenance therapy via a Dry Powder Inhaler (DPI). Patients and methods The cross-sectional, multi-country PIFotal study included 1434 COPD patients (≥40 years) using a DPI for maintenance therapy. PIF was measured with the In-Check DIAL G16, and sPIF was defined as a typical PIF lower than required for the device. Inhalation technique was assessed by standardised evaluation of video recordings and grouped into 10 steps. Patients completed the “Test of Adherence to Inhalers” questionnaire. HCRU was operationalised as COPD-related costs for primary healthcare, secondary healthcare, medication, and total COPD-related costs in a 1-year period. Results Participants with sPIF had higher medication costs compared with those with optimal PIF (cost ratio [CR]: 1.07, 95% CI [1.01, 1.14]). Multiple inhalation technique errors were associated with increased HCRU. Specifically, “insufficient inspiratory effort” with higher secondary healthcare costs (CR: 2.20, 95% CI [1.37, 3.54]) and higher total COPD-related costs (CR: 1.16, 95% CI 1.03–1.31). “no breath-hold following the inhalation manoeuvre (<6 s)” with higher medication costs (CR: 1.08, 95% CI [1.02, 1.15]) and total COPD-related costs (CR 1.17, 95% CI [1.07, 1.28]), and “not breathing out calmly after inhalation” with higher medication costs (CR: 1.19, 95% CI [1.04, 1.37]). Non-adherence was not significantly associated with HCRU. Conclusion sPIF and inhalation technique errors were associated with higher COPD-related healthcare utilisation and costs in COPD patients on DPI maintenance therapy.

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Clinical And Economic Burden Of Asthma And Chronic Obstructive Pulmonary Disease (Copd) In Poland: Estimated Impact Of Poor Inhalation Technique With Inhaled Corticosteroid And Long-Acting Beta Agonist Fixed-Dose Combinations

Cited by 2 publications

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Critical inhaler errors in asthma and COPD: a systematic review of impact on health outcomes

Critical inhaler errors in asthma and COPD: a systematic review of impact on health outcomes

Suboptimal Peak Inspiratory Flow and Critical Inhalation Errors are Associated with Higher COPD-Related Healthcare Costs

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