1981
DOI: 10.1016/s0140-6736(81)92636-2
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Clinical and Economic Consequences of Wound Sepsis After Appendicectomy and Their Modification by Metronidazole or Povidone Iodine

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Cited by 44 publications
(24 citation statements)
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“…1 The significantly longer hospital stay in our study of the infected group is in agreement with previous studies. [4][5][6][7] Prophylactic use of systemic antibiotics, many of which have been used either alone or in combination, has resulted in a significant reduction in wound infection rate.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…1 The significantly longer hospital stay in our study of the infected group is in agreement with previous studies. [4][5][6][7] Prophylactic use of systemic antibiotics, many of which have been used either alone or in combination, has resulted in a significant reduction in wound infection rate.…”
Section: Discussionsupporting
confidence: 93%
“…A considerable morbidity following appendectomy is caused by wound infection, [1][2][3][4][5] the rate of which ranges from 9% to 30% in early appendicitis and may reach up to 70% in advanced appendicitis. [3][4][5][6] Systemic antibiotics were shown to reduce the wound infection rate significantly.…”
mentioning
confidence: 99%
“…Alguns estudos deste tipo, incluíram somente pacientes submetidos à cirurgia de apendicectomia (21)(22) . Avaliando a irrigação com PVP-I no intra-operatório dessas cirurgias, não foram encontrados resultados semelhantes aos citados anteriormente (17) .…”
Section: Discussionunclassified
“…Somente para as apendicectomias tardias, a combinação de antibiótico sistê-mico e agente antimicrobiano tópico mostrou aumento significativo na incidência de infecção da ferida cirúrgi-ca (21) , contrariamente ao esperado e aos resultados obtidos nos estudos com feridas abdominais gerais (20) . Com desenho metodológico diferente, autores (22) constataram resultados significativamente melhores para os pacientes do grupo tratado com antibiótico no que se referiu às taxas de infecção geral (p<0,01) e, especificamente, para os pacientes com apêndice perfurado ou gangrenado (p<0,05), à ausência de isolamento de bacteróides e ao menor tempo de hospitalização.…”
Section: Discussionunclassified
“…Con cerning the choice of the drug, metronidazole alone, given systemically or rectally as a single shot is an effective agent to prevent wound infection [20,80,81]. Topical antiseptics or antibiotics did not show a significant bene fit [82] but combinations seem to have some value in advanced appendicitis [83]. The first-and second-genera tion cephalosporins should be administered together with metronidazole; only the third-generation cephalosporins are as effective as combinations, but they should be reserved as therapeutic antibiotic treatment for estab lished infections [31,77],…”
Section: Appendixmentioning
confidence: 99%