Clinical and Electroencephalographic Observations in Alzheimer's Disease

Letemendia, F. J. J.; Pampiglione, G.

doi:10.1136/jnnp.21.3.167

Cited by 91 publications

(36 citation statements)

References 6 publications

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“…This is analogous to our finding of a positive correlation between equivalent dipole strength in the theta band and mental deterioration. For the alpha band several authors have described decreased activity with increasing cognitive decline, comparable to our finding of reduced intensity in the alpha band with decreasing cognitive function (Letemendia and Pampligione, 1958;Gordon and Sim, 1967;Saletu et al, 1991).…”

Section: Discussionsupporting

confidence: 90%

Correlation between cognitive brain function and electrical brain activity in dementia of Alzheimer type

Dierks

Frölich

Ihl

et al. 1995

J. Neural Transmission

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Psychometric tests which assess cognitive brain function in dementia disorders are partly prone to artifacts, e.g., the experience of the investigator and the cooperation of the patient influences the results. An objective way to assess the degree of cognitive disturbance could be to measure neuronal activity represented by the electrical brain activity. The aim of the present study was to investigate how well cognitive function in dementia assessed by psychometric tests correlates with electrical brain activity (EEG). Multichannel EEG data was reduced into 3-D intracerebral equivalent dipole EEG generators allowing a more convenient statistical data management and valid physiological data interpretation. 35 patients suffering from dementia of Alzheimer type were investigated. An increase of dipole strength in the slow frequency bands, a more anterior equivalent dipole of alpha- and beta-activity, and a slowing of the EEG with increasing cognitive deterioration could be demonstrated. The results support the hypothesis that the amount of disturbance of cognitive function in dementia can be assessed by measuring the electrical activity of the brain.

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Section: Discussionsupporting

confidence: 90%

Correlation between cognitive brain function and electrical brain activity in dementia of Alzheimer type

Dierks

Frölich

Ihl

et al. 1995

J. Neural Transmission

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“…As reported in earlier studies by other authors most patients with Alzheimer's disease show different EEG abnormalities, mainly in the form of slow waves [24][25][26]. In our study we have registered pathological EEG changes such as reduced background activity and an increase in the amount of theta and delta waves in 82% of our patients.…”

Section: Discussionsupporting

confidence: 63%

The value of quantitative EEG in differential diagnosis of Alzheimer's disease and subcortical vascular dementia

Gaweł

Zalewska

Szmidt-Salkowska

et al. 2009

Journal of the Neurological Sciences

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“…EEG findings in dementia include slowing of the dominant posterior rhythm, an increase in diffuse slow (delta and theta) activity, and a reduction in alpha and beta activity (Letemendia & Pampiglione, 1958;Soininen, Partanen, Heilkala, & Riekkinen, 1982;Rae-Grant et al, 1987). In comparing demented to delirious patients, a significant variable is the severity of illness.…”

Section: Delirium and Dementiamentioning

confidence: 95%

Utility of EEG in Delirium: Past Views and Current Practice

Brenner

1991

Int. Psychogeriatr.

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The EEG is a useful and, at times, an essential test in the evaluation of delirium. In most patients with delirium, the EEG will show diffuse slowing and thus is helpful in differentiating organic etiologies from functional, psychiatric disorders. The degree of the EEG changes correlates with the severity of the encephalopathy so that the EEG may be used to help monitor therapy. In some delirious patients, the EEG may indicate whether the patient is suffering from focal, rather than global, impairment. Furthermore, the EEG is the only test that can identify an ongoing epileptic state (e.g., nonconvulsive status epilepticus) as being responsible for the clinical picture of confusion. Other electrophysiological tests that may prove helpful in the evaluation of delirium, such as computerized EEG spectral analysis, topographic brain mapping, and sleep studies, are briefly reviewed.

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Clinical and Electroencephalographic Observations in Alzheimer's Disease

Cited by 91 publications

References 6 publications

Correlation between cognitive brain function and electrical brain activity in dementia of Alzheimer type

Correlation between cognitive brain function and electrical brain activity in dementia of Alzheimer type

The value of quantitative EEG in differential diagnosis of Alzheimer's disease and subcortical vascular dementia

Utility of EEG in Delirium: Past Views and Current Practice

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