Clinical and Electrophysiological Profile of Brugada Syndrome in the Tunisian Population

Ouali, Sana; Boughzéla, Essia; Haggui, Abdeddayem; Haouala, Habib; Battikh, Kais; Ameur, Youssef Ben; Kraïem, Sondos; Krichen, S.; Hentati, Mourad; Kammoun, S.

doi:10.1111/j.1540-8159.2010.02890.x

Cited by 14 publications

(13 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 1 The rate of diabetes and coronary artery disease (CAD) is on the rise in the developing countries 2 , thereby sowing the seeds for the sprawling dissemination of SCD in this burgeoning African population of patients with cardiovascular disease (CVD). 3 Even though SCD has been reported in Africans, 4–13 its epidemiology remains unknown in sub-Saharan Africa (SSA) owing to the lack of prospective cohort surveys. Identifying the demographic and clinical profiles of patients experiencing cardiac arrest may provide opportunities for improving prevention in SSA, where heart diseases are still neglected.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of sudden cardiac death in Cameroon: the first population-based cohort survey in sub-Saharan Africa

Bonny

Tibazarwa

Mbouh

et al. 2017

International Journal of Epidemiology

View full text Add to dashboard Cite

BackgroundIncidence estimates of sudden cardiac death (SCD) in sub-Saharan Africa (SSA) are unknown.MethodOver 12 months, the household administrative office and health community committee within neighbourhoods in two health areas of Douala, Cameroon, registered all deaths among 86 188 inhabitants aged >18 years. As part of an extended multi-source surveillance system, the Emergency Medical Service (EMS), local medical examiners and district hospital mortuaries were also surveyed. Whereas two physicians investigated every natural death, two cardiologists reviewed all unexpected natural deaths.ResultsThere were 288 all-cause deaths and 27 (9.4%) were SCD. The crude incidence rate was 31.3 [95% confidence interval (CI): 20.3–40.6]/100 000 person-years. The age-standardized rate by the African standard population was 33.6 (95% CI: 22.4–44.9)/100 000 person-years. Death occurred at night in 37% of cases, including 11% of patients who died while asleep. Out-of-hospital sudden cardiac arrest occurred in 63% of cases, 55.5% of which occurred at home. Of the 88.9% cases of witnessed cardiac arrest, 63% occurred in the presence of a family member and cardiopulmonary resuscitation was attempted only in 3.7%.ConclusionThe burden of SCD in this African population is heavy with distinct characteristics, whereas awareness of SCD and prompt resuscitation efforts appear suboptimal. Larger epidemiological studies are required in SSA in order to implement preventive measures, especially in women and young people.

show abstract

Section: Introductionmentioning

confidence: 99%

Epidemiology of sudden cardiac death in Cameroon: the first population-based cohort survey in sub-Saharan Africa

Bonny

Tibazarwa

Mbouh

et al. 2017

International Journal of Epidemiology

View full text Add to dashboard Cite

show abstract

“…Another 81 studies were excluded as they did not report data regarding SCB use, outcome of interest, or did not provide sufficient data to calculate odds ratio (OR). Therefore, a total of 18 studies were included in this meta‐analysis 3,14‐30 . Figure 1 outlines the search and literature review process.…”

Section: Resultsmentioning

confidence: 99%

The utility of drug challenge testing in Brugada syndrome: A systematic review and meta‐analysis

Rattanawong

Kewcharoen

Kanitsoraphan

et al. 2020

Cardiovasc electrophysiol

View full text Add to dashboard Cite

Introduction Brugada syndrome (BrS) is associated with ventricular arrhythmia leading to sudden cardiac death. Risk stratification is challenging, as major arrhythmic events (MAEs) are rare. We assessed the utility of drug challenge testing in BrS by a systematic review and meta‐analysis. Methods and Results We comprehensively searched the databases of MEDLINE and EMBASE from inception to May 2019. Included studies compared the incidence of MAE between spontaneous and drug challenge–induced Type 1. Mixed‐effects Poisson regression was used to calculate the incidence rate ratio (IRR). Eighteen studies from 2006 to 2018 were included (4099 patients, mean follow‐up: 4.5 years). Pooled annual incidences of MAE in spontaneous, drug challenge induced (regardless of symptoms), asymptomatic drug challenge induced, and symptomatic drug challenge–induced Type 1 were 23.8 (95% confidence interval [CI]: 19.8–27.8), 6.5 (95% CI: 3.9–9.1), 2.1 (95% CI: −0.3 to 4.4), and 19.6 (95% CI: 9.9–29.3) per 1000 person‐years, respectively. The incidence of MAE between symptomatic drug challenge induced and asymptomatic spontaneous Type 1 was not statistically different (IRR = 1.0; 95% CI: 0.6–1.7). Conclusions The incidence of MAE in drug challenge–induced Type 1 in asymptomatic patients is low. The incidence of MAE between symptomatic drug challenge induced and asymptomatic spontaneous Type 1 was similar.

show abstract

“…Almost all leading causes of SCD have been described in Africa (Table 1). Indeed some reports of SCD in sub-Saharan Africa have been published;30-37 and several studies report conflicting data regarding the prevalence of CHD in sub-Saharan Africa 38-40…”

Section: Rationalementioning

confidence: 99%

Rationale and design of the Pan-African Sudden Cardiac Death survey: the Pan-African SCD study : cardiovascular topic

Bonny

Ngantcha

Amougou

et al. 2014

CVJA

View full text Add to dashboard Cite

SummaryBackgroundThe estimated rate of sudden cardiac death (SCD) in Western countries ranges from 300 000 to 400 000 annually, which represents 0.36 to 1.28 per 1 000 inhabitants in Europe and the United States. The burden of SCD in Africa is unknown. Our aim is to assess the epidemiology of SCD in Africa.MethodsThe Pan-Africa SCD study is a prospective, multicentre, community-based registry monitoring all cases of cardiac arrest occurring in victims over 15 years old. We will use the definition of SCD as ‘witnessed natural death occurring within one hour of the onset of symptoms’ or ‘unwitnessed natural death within 24 hours of the onset of symptoms’. After appro val from institutional boards, we will record demographic, clinical, electrocardiographic and biological variables of SCD victims (including survivors of cardiac arrest) in several African cities. All deaths occurring in residents of districts of interest will be checked for past medical history, circumstances of death, and autopsy report (if possible). We will also analyse the employment of resuscitation attempts during the time frame of sudden cardiac arrest (SCA) in various patient populations throughout African countries.ConclusionThis study will provide comprehensive, contemporary data on the epidemiology of SCD in Africa and will help in the development of strategies to prevent and manage cardiac arrest in this region of the world.

show abstract

Clinical and Electrophysiological Profile of Brugada Syndrome in the Tunisian Population

Abstract: BS is present in the North African population and is probably under-recognized. Tunisian patients with BS share with their western and Asiatic counterparts similar clinical profile.

Cited by 14 publications

References 36 publications

Epidemiology of sudden cardiac death in Cameroon: the first population-based cohort survey in sub-Saharan Africa

Epidemiology of sudden cardiac death in Cameroon: the first population-based cohort survey in sub-Saharan Africa

The utility of drug challenge testing in Brugada syndrome: A systematic review and meta‐analysis

Rationale and design of the Pan-African Sudden Cardiac Death survey: the Pan-African SCD study : cardiovascular topic

Contact Info

Product

Resources

About