Clinical and electrophysiological studies of human immunodeficiency virus—seropositive men without AIDS

Smith, Torben; Jakobsen, Janus Christian; Gaub, Janne E.; Helweg-Larsen, Susanne; Trojaborg, W.

doi:10.1002/ana.410230313

Cited by 67 publications

(18 citation statements)

References 9 publications

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“…Examination of the infected cats revealed numerous functional abnormalities including delayed righting and pupillary reflexes, anisocoria, altered visual and auditory evoked potentials and abnormal sleep patterns. These findings are consistent with those described for HIV infection in humans which can cause alterations in both visual (Malessa et al, 1989) and auditory (Goodin et al, 1990;Boccellari et al, 1993;Smith et al, 1988;Pagano et al, 1992;Rosenhall et al, 1989;Koralnik et al, 1990;Jabbari et al, 1993) evoked potentials. In addition, abnormal sleep patterns, similar to the findings of this study, have also been reported in HIV-infected individuals (Aldrich et al, 1988;St.…”

Section: Discussionsupporting

confidence: 92%

Neurological Abnormalities Associated with Feline Immunodeficiency Virus Infection

Phillips

Prospéro-Garcı́a²,

Puaoi³

et al. 1994

Journal of General Virology

126

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Specific pathogen-free cats were infected with the Maryland strain of FIV (FIV-MD) for the purpose of assessing the effects of FIV infection on the central nervous system (CNS). Two separate studies were performed, involving a total of 13 infected cats and six age-matched, sham-inoculated controls. All animals infected with FIV-MD seroconverted by 8 weeks postinfection and virus was recovered from peripheral blood mononuclear cells of all infected cats. All of the infected animals had lower absolute CD4 + cell counts and decreased CD4+/CD8 ÷ ratios. Virus was recovered from the cerebrospinal fluid (CSF) of certain infected individuals, and antiviral antibody and pleocytosis were evident in the CSF of the majority of infected cats.Additionally, virus was recovered from tissue explants from the cerebellum, midbrain and brainstem of one sacrificed FIV + eat. Specific neurological changes ineluded anisocoria, delayed righting reflex and delayed pupillary reflex, as well as delayed visual and auditory evoked potentials, and marked alterations in sleep patterns similar to those reported for human immunodeficiency virus (HIV)-positive individuals. Histological evaluation revealed the presence of perivascular cuffing and glial nodules in FIV-infected cats. These results indicate that FIV causes an acute neurological disease that closely resembles the early neurological effects of HIV infection in humans and should serve well as an animal model for lentivirus-induced CNS disease.

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Section: Discussionsupporting

confidence: 92%

Neurological Abnormalities Associated with Feline Immunodeficiency Virus Infection

Phillips

Prospéro-Garcı́a²,

Puaoi³

et al. 1994

Journal of General Virology

126

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“…For both groups, the most commonly observed abnormality was the increased latency -in agreement with other studies that have studied this potential in the same population (23,24). Abnormalities in the P300 before the clinical onset of symptoms -such as neurological and cognitive deficits, which are part of the AIDS dementia complex (8,25) -are reported by several studies (14,4) On the AMLR and P300 analysis, the percentage of abnormalities was higher for group I when compared to group II, and the values obtained for the two groups were very similar. Thus, although individuals from Group II were clinically more affected than those from Group I, the results presented by them were not significantly worse.…”

Section: Discussionsupporting

confidence: 75%

Manifestações eletrofisiológicas em adultos com HIV/AIDS submetidos e não-submetidos à terapia anti-retroviral

Matas

Silva²,

Marcon³

et al. 2010

Pró-Fono R. Atual. Cient.

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TEMA: os potenciais evocados auditivos (PEA) avaliam a atividade neuroelétrica na via auditiva, desde o nervo auditivo até o córtex cerebral, em resposta a um estímulo ou evento acústico. Estudos demonstram anormalidades eletrofisiológicas em indivíduos com HIV/AIDS. OBJETIVO: caracterizar as manifestações eletrofisiológicas da audição em adultos com HIV/AIDS, comparando os resultados obtidos no grupo exposto a tratamento anti-retroviral com os obtidos no grupo não exposto a tratamento. MÉTODO: realizada avaliação eletrofisiológica da audição (PEATE, PEAML e P300) em 56 indivíduos portadores do HIV/AIDS, sendo 24 do Grupo I (não expostos ao tratamento anti-retroviral) e 32 do Grupo II (expostos ao tratamento). RESULTADOS: foram encontradas alterações em todos os PEA nos indivíduos com HIV/AIDS, principalmente no PEATE; sendo que neste, o grupo exposto ao tratamento antiretroviral apresentou mais alterações. CONCLUSÃO: indivíduos com HIV/AIDS podem apresentar alterações no sistema nervoso auditivo periférico e central, sendo que o grupo exposto a tratamento anti-retroviral apresenta mais alterações na via auditiva em tronco encefálico.

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“…Thirty one individuals were on prescribed medication when first seen, and this was more common among seropositive subjects (4/32 (12 5%) seronegative, subjects 20/80 (25%) group II/III; 7/15 (46 7%) group IV; X2 5 1, p < 0 05). Of the 127 subjects 54 had used cannabis, 21 LSD, and 17 amphetamines or cocaine. Only one subject, who was seronegative, had used intravenous drugs.…”

Section: Resultsmentioning

confidence: 99%

Neurological and neuropsychological performance in HIV seropositive men without symptoms.

McAllister

Herns

Harrison

et al. 1992

Journal of Neurology, Neurosurgery & Psychiatry

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with AIDS,4 though pathological studies show an even higher prevalence of a subacute encephalitis,5 which is believed to be due to HIV itself.6 Five to 10% of subjects also develop signs of damage to the peripheral nervous system,7 and at postmortem as many as 25% show signs of spinal cord disease.8 Controversy exists over the possibility that asymptomatic seropositive individuals might show subclinical evidence of evolving damage to either the central or peripheral nervous system. In particular it has been suggested that such individuals show impaired performance when subjected to a battery of neuropsychological tests.9 At the end of 1987 we therefore embarked upon a longitudinal study ofa cohort of seropositive and seronegative homosexual men, who underwent neurological, neurophysiological, and neuropsychological tests at six to nine month intervals. Annual recording of event related evoked potentials (P300s), central motor conduction times with magnetic stimulation, anid magnetic resonance imaging of the brain (MRI scanning) were added to the assessments at the second visit. This report of the cross sectional comparison of seropositive and seronegative subjects combines the clinical, neuropsychological, and neurophysiological data from the first visit and the MRI, magnetic stimulation, and P300 data collected for the first time at the second visit.

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Clinical and electrophysiological studies of human immunodeficiency virus—seropositive men without AIDS

Cited by 67 publications

References 9 publications

Neurological Abnormalities Associated with Feline Immunodeficiency Virus Infection

Neurological Abnormalities Associated with Feline Immunodeficiency Virus Infection

Manifestações eletrofisiológicas em adultos com HIV/AIDS submetidos e não-submetidos à terapia anti-retroviral

Neurological and neuropsychological performance in HIV seropositive men without symptoms.

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