Clinical and ElectrophysiologicAspects of Guillain Barre Syndrome among Children: Experience at Referral Tertiary Care Hospital in Bangladesh

Abstract

Background: Guillain Barre Syndrome (GBS) is an acute polyradiculopathy which is quite common in all ages.
 Objective: The aim of this study was to evaluate the clinical and electrophysiologicaspects of Guillain Barre Syndrome (GBS) in children.
 Methodology: This cross-sectional study was carried out in the Department of Neurophysiology of National Institute of Neurosciences and Hospital, Bangladesh from July 2016 to June 2018. Patients under 18 years of age fulfilling Brighton diagnostic criteria for GBS were included in this study. These patients were evaluated by detailed history, physical examination, and electrophysiological findings.
 Results: A total of 82 patients of GBS were enrolled in this study. The mean age was 12.93± 5.02 years (range 1 to<18 years). Most of the patients were male (64.6%) and from the middle-income group (70.73%). About Fourty eight percent of patients had a history of preceding illness among which gastrointestinal infection(24.3%) was the most common. Tingling and paresthesiaswas complained by 32.4% of patients as the first symptom. AMAN(61%) was the most common GBS variant followed by AIDP(26.8%). 9 (11%) patients needed ICU support among them AIDP was more frequent.
 Conclusion: AMAN is the most common variant among children in this population by electrophysiologic testing.
 Journal of National Institute of Neurosciences Bangladesh, 2019;5(1): 2-7

Clinical and biochemical profile of Guillain Barré Syndrome in Pakistan

“…These figures are in line with research conducted by Debnath and his colleagues. 23 Many types of researches presented the history of a preceding event in 50 to 71% of GBS patients as is presented by our research. The elevated incidence of GI infections in this study might be due to poor hygienic conditions and elevated occurrence of gut pathogens in our country.…”

Children with Guillain-Barre Syndrome: A Comparison between AIDP and AMAN variants among Patients admitted in a Tertiary Care Hospital

“…The frequency of AIDP in children ranged between 32% and 74%, and AMAN between 11% and 48% in different literature. AIDP has been reported to be more common in Argentina, Germany, Iran, Turkey, Oman, and Northeast China 4,15,16,27,28 , whereas AMAN was found to be more common in Japan, China, Mexico, Bangladesh 5,17,29,30 . Although possible reasons for this geographical variation of electrophysiological subtypes remain to be elucidated, the heterogeneity of the antecedents infections and the indigenous risk factors are speculated to be important factors 31 .…”