Clinical and Epidemiologic Features of Viral Gastroenteritis in Hospitalized Children: An 11-Year Surveillance in Palermo (Sicily)

Amodio, Emanuele; Grazia, Simona De; Genovese, D.; Bonura, Floriana; Filizzolo, Chiara; Collura, Alessio; Bernardo, Francesca Di; Giammanco, Anna

doi:10.3390/v15010041

Cited by 5 publications

(9 citation statements)

References 35 publications

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“…Five (5) samples were found negative with conventional polymerase chain reaction 8.3 % (5/60) and 25 samples 41.7 % (25/60) were untypeable. The four (4) P different strains of VP4 detected were P [4], P [8], P [10] and P[11. The most predominant P genotype observed was P [4] with a prevalence of 23.3 % (14/60), followed by P [8] strain 10 % (6/60), P [10] and P [11] prevalence's rate were 6.7 % and 3.3% respectively.…”

Section: Rotavirus Infection and Socio-demographic Factorsmentioning

confidence: 99%

“…The four (4) P different strains of VP4 detected were P [4], P [8], P [10] and P[11. The most predominant P genotype observed was P [4] with a prevalence of 23.3 % (14/60), followed by P [8] strain 10 % (6/60), P [10] and P [11] prevalence's rate were 6.7 % and 3.3% respectively. The mixed infections found in this study population were P [8]P [10].…”

Section: Rotavirus Infection and Socio-demographic Factorsmentioning

confidence: 99%

“…The most predominant P genotype observed was P [4] with a prevalence of 23.3 % (14/60), followed by P [8] strain 10 % (6/60), P [10] and P [11] prevalence's rate were 6.7 % and 3.3% respectively. The mixed infections found in this study population were P [8]P [10]. The P [6] and P [9] genotypes were not found in circulation during this study period.…”

Section: Rotavirus Infection and Socio-demographic Factorsmentioning

confidence: 99%

“…G4P [4] was found to be the prominent combination at 11.7 % (7/60) followed by G12P [4] with a prevalence rate of 6.7 % (4/60). Other combinations such as G4P [11] and G9 [10] were represented at a low frequency of 1.7 % (1/60) each. The most prevalent mixed infections for the G-P combination were G2G8P [10] and G4G10P [8] at a frequency of 3.3 % (2/60).…”

Section: Rotavirus Infection and Socio-demographic Factorsmentioning

confidence: 99%

“…Other combinations such as G4P [11] and G9 [10] were represented at a low frequency of 1.7 % (1/60) each. The most prevalent mixed infections for the G-P combination were G2G8P [10] and G4G10P [8] at a frequency of 3.3 % (2/60). The presence of P[NT] (non-typeable) strain of P in combination with G typing produced G4P[NT] and G12P[NT] at a frequency of 10 % (6/60), followed by G9 P[NT] with the frequency of 8.3 % (5/60).…”

Section: Rotavirus Infection and Socio-demographic Factorsmentioning

confidence: 99%

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Molecular Characterization and Risk Factors Associated with Rotavirus among Children with diarrhoea.

Demekong,

Onu,

Okorie

et al. 2024

Preprint

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Introduction: Rotavirus-induced acute diarrhoea continues to pose a significant health threat to children under 5 years old worldwide, despite the availability of effective vaccines. This study aimed to assess the prevalence, associated risk factors, and circulating genotypes of rotavirus among children under 5 admitted to Ikom Medical Centre due to diarrhea. Methodology: Stool samples were collected from 294 children under 5 with diarrhoea at Ikom Medical Centre. Rotavirus antigen detection was performed using rapid chromatographic immunoassay. Molecular techniques such as polyacrylamide gel electrophoresis (PAGE), RT-PCR, and semi-nested multiplex RT-PCR were used to analyze rotavirus strains. Data were obtained through questionnaires, and statistical significance was assessed using the chi-square test (P < 0.05). Results: Among the 294 samples, 20.4% (60/294) tested positive for rotavirus. Significant risk factors influencing rotavirus prevalence included feeding status, toilet system, and duration of diarrhoea. The most prevalent genotype for VP7 was G4 (26.7%), and for VP4, it was genotype P[4] (23.3%). Predominant genotype combinations were G4P [4] (11.6%) and G12P[4] (6.7%), while non-typeable P[NT] was observed in 41.7% of cases. Conclusion: This study highlights the circulation of rotavirus in Ikom, Cross River State, emphasizing its neglected status despite its significant global impact on child mortality. Urgent attention is needed to address rotavirus as a serious public health concern, particularly in low-resource settings.

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Section: Rotavirus Infection and Socio-demographic Factorsmentioning

confidence: 99%

Section: Rotavirus Infection and Socio-demographic Factorsmentioning

confidence: 99%

Section: Rotavirus Infection and Socio-demographic Factorsmentioning

confidence: 99%

Section: Rotavirus Infection and Socio-demographic Factorsmentioning

confidence: 99%

Section: Rotavirus Infection and Socio-demographic Factorsmentioning

confidence: 99%

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Molecular Characterization and Risk Factors Associated with Rotavirus among Children with diarrhoea.

Demekong,

Onu,

Okorie

et al. 2024

Preprint

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Changes in the epidemiology and clinical characteristics of viral gastroenteritis among hospitalized children in the Mainland of China: a retrospective study from 2016 to 2020

Li,

Guo,

et al. 2024

BMC Pediatr

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Background Acute gastroenteritis (AGE) causes significant morbidity in children worldwide; however, the disease burden of children hospitalized with viral gastroenteritis in China has been rarely described. Through this study, we analyzed the data of hospitalized children with viral gastroenteritis to explore the changes in the epidemiology and clinical characteristics of viral gastroenteritis in the mainland of China. Methods Data were extracted from Futang Children's Medical Development Research Center (FRCPD), between 2016 and 2020, across 27 hospitals in 7 regions. The demographics, geographic distribution, pathogenic examination results, complications, hospital admission date, length of hospital stays, hospitalization charges and outcomes were collected and analyzed. Results Viral etiological agents included rotavirus (RV), adenovirus (ADV), norovirus (NV) and coxsackievirus (CV) that were detected in 25,274 (89.6%), 1,047 (3.7%), 441 (1.5%) and 83 (0.3%) cases. There was a higher prevalence of RV and NV infection among children younger than 3 years of age. RV and NV had the highest detection rates in winter, while ADV in summer. Children with viral gastroenteritis were often accompanied by other diseases, such as myocardial diseases (10.98–31.04%), upper respiratory tract diseases (1.20–20.15%), and seizures (2.41–14.51%). Among those cases, the co-infection rate with other pathogens was 6.28%, with Mycoplasma pneumoniae (M. pneumoniae), Epstein-Barr virus (EBV), and influenza virus (FLU) being the most common pathogens. The median length of stay was 5 days, and the median cost of hospitalization corresponded to587 US dollars. Conclusions This finding suggests that viral gastroenteritis, especially those caused by RV, is a prevalent illness among younger children. Co-infections and the presence of other diseases are common. The seasonality and regional variation of viral etiological agents highlight the need for targeted prevention and control measures. Although viral gastroenteritis rarely leads to death, it also results in a significant economic burden on healthcare systems.

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Epidemiology and clinical characteristics of acute viral gastroenteritis in 350 paediatric patients hospitalised between 2019 and 2022 in the Military Institute of Medicine – National Research Institute in Warsaw, Poland: a single-centre retrospective analysis

Guzek,

Tomaszewski,

Piechota

et al. 2024

Pediatr Med Rodz

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Introduction and objective: Acute gastroenteritis, a common childhood illness worldwide, manifests with symptoms including fever, abdominal pain, vomiting, and diarrhoea. It is highly contagious, with transmission occurring through contaminated water, food, or poor hygiene. Globally, 1.7 billion cases of diarrhoeal diseases are diagnosed annually, causing approximately 525,000 deaths among children under the age of five. Dehydration caused by diarrhoea is a primary cause of hospitalisation, particularly in developing countries. Aim: Analysis of the aetiology, frequency, and seasonal distribution of viral pathogens responsible for acute gastroenteritis in children hospitalised between 2019 and 2022 at the Military Institute of Medicine – National Research Institute in Warsaw, Poland. Materials and methods: Medical records of patients aged 0 to 18 diagnosed with rotavirus, norovirus, and adenovirus-induced acute gastroenteritis were analysed. The pathogens had been identified with reliable immunochromatographic tests. Exclusion criteria encompassed bacterial infections, dietary errors, and inflammatory conditions. Data examined included age, gender, aetiology of gastroenteritis, seasonality, duration of hospitalisation, and clinical symptoms (diarrhoea, vomiting, fever, abdominal pain, and dehydration). Laboratory results such as white blood cell count, C-reactive protein, electrolyte levels, and organ function markers were also evaluated. Results: Data from 350 children hospitalised between 2019 and 2022 were analysed. The highest number of hospitalisations occurred in 2019 and 2022, with fewer cases in 2020–2021, likely reflecting the impact of the COVID-19 pandemic. Most patients were between 6 and 12 months old. Rotavirus infection commonly presented with fever, vomiting, diarrhoea, and dehydration. Adenovirus and mixed infections were associated with slightly higher C-reactive protein levels, while rotavirus infections showed mildly elevated aspartate aminotransferase levels. Haematocrit, blood urea nitrogen, creatinine, and electrolyte levels were similar across all cases. Conclusions: Our analysis showed that rotavirus was the most frequent cause of acute viral diarrhoea in children, followed by norovirus and adenovirus, with mixed infections being the least common. The peak incidence occurred in autumn and winter, except in 2021, reflecting changes in the dynamics of infections related to the coronavirus pandemic. Biochemical findings were not sufficiently characteristic to infer the aetiology of the disease.

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Clinical and Epidemiologic Features of Viral Gastroenteritis in Hospitalized Children: An 11-Year Surveillance in Palermo (Sicily)

Cited by 5 publications

References 35 publications

Molecular Characterization and Risk Factors Associated with Rotavirus among Children with diarrhoea.

Molecular Characterization and Risk Factors Associated with Rotavirus among Children with diarrhoea.

Changes in the epidemiology and clinical characteristics of viral gastroenteritis among hospitalized children in the Mainland of China: a retrospective study from 2016 to 2020

Epidemiology and clinical characteristics of acute viral gastroenteritis in 350 paediatric patients hospitalised between 2019 and 2022 in the Military Institute of Medicine – National Research Institute in Warsaw, Poland: a single-centre retrospective analysis

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