Clinical and Epidemiologic Features of Visceral Leishmaniasis in Children in Southwestern China

Miao, Ruixue; Wang, Zhong Lin; Guo, Qin; Wen, Yang; Liao, Qiong; Zhu, Yu; Shu, Min; Wan, Chaomin

doi:10.1097/inf.0000000000001343

Cited by 11 publications

(14 citation statements)

References 15 publications

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“…In the present study, fever, splenomegaly and hepatomegaly were the most prevalent clinical signs and anaemia, leukopenia, and thrombocytopenia were the prominent laboratory findings, which agrees with studies conducted in southwest Iran, 6 in southwest China 7 and in north Cyprus. 8 Diarrhoea was observed as a non-specific symptom in 36.8% of these children.…”

Section: Discussionsupporting

confidence: 92%

Paediatric visceral leishmaniasis: a retrospective study on clinical manifestations, demographic features and laboratory findings of hospitalised cases in Iran between 2006 and 2016

et al. 2018

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Visceral leishmaniasis (VL) is a neglected disease. Our retrospective study describes 38 clinical and epidemiological characteristics of VL in patients admitted to a paediatric hospital in Tehran, Iran, who came from different geographical regions, indicating that the disease has spread to most parts of the country. Some 76.3% of the children documented suffered with symptoms of the disease for two months before admission.

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Section: Discussionsupporting

confidence: 92%

Paediatric visceral leishmaniasis: a retrospective study on clinical manifestations, demographic features and laboratory findings of hospitalised cases in Iran between 2006 and 2016

et al. 2018

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“…Although the literature on VL is rather unanimous regarding symptom frequency, a few studies which report varying findings exist. For instance, a study by Krepis et al (11) reported that all (100%) of their patients had pallor; however, in the current study, pallor was observed in only 55.6% of patients, while Miao et al (10) reported a frequency of 33%. Among our patients, loss of appetite (66.7%) and weight loss (55.6%) were also primary symptoms, while in the study by Krepis et al (11) loss of appetite and subsequent weight loss were evaluated together, and were observed in just 32.6% of their cases.…”

Section: Initial Symptomatologycontrasting

confidence: 77%

“…It is also important to note that Abdinia et al (6) found that liver involvement was present in all cases of mortality in their patient group. Lymphadenopathy was the third most common finding in our study group with a frequency of 50%, however, Miao et al (10) reported that it was present in only 33% of their patients. In the current study, bleeding manifestations were observed in the form of petechiae in 2 (11.1%) patients, Krepis et al (11) reported bleeding manifestations in 7% of their patients (12), while Abdinia et al (6) reported petechiae and purpura in 11.5% of their study group.…”

Section: Physical Examination and Laboratory Findingscontrasting

confidence: 49%

“…Similar to our findings, fever has been reported tof be the most frequent symptom among VL patients. Fever frequency has been reported as 94.2% in a study from Iran (6), 100% in the Black Sea Region of Turkey (7), 95% in Greece (8), 95% in France (9), and 98% in China (10). Although the literature on VL is rather unanimous regarding symptom frequency, a few studies which report varying findings exist.…”

Section: Initial Symptomatologymentioning

confidence: 99%

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Visceral Leishmaniasis in Children in Southern Turkey: Evaluation of Clinical and Laboratory Findings and Liposomal Amphotericin B Treatment

Karagün¹,

Özgür²,

Şaşmaz³

et al. 2019

jpr

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Visceral leishmaniasis (VL) is a systemic infection that spreads hematogenously and affects the reticuloendothelial system by the infection of macrophages. VL occurs commonly in children, and only rarely in adults. VL should be considered in patients with prolonged high fever, hepatosplenomegaly, pancytopenia, weight loss, pallor and hypergammaglobulinemia. Materials and Methods: In this study, a total of 18 pediatric patients-9 (50%) males and 9 (50%) females-treated for VL at our clinic from January 2004 to July 2014 were analyzed retrospectively. Average time from symptom onset to hospital admission was 64±21 days (range: 30-100 days). The mean age of patients was 88±40 months (range: 36-182 months). Results: The most common symptom at presentation was fever (88.9%). Other common symptoms were fatigue, chills, weight loss and anorexia. Physical examination revealed splenomegaly and hepatomegaly in all patients. Anemia (92.4%), leukopenia (78.7%) and thrombocytopenia (76.2%) were the most prominent laboratory abnormalities and 82.2% of the patients were pancytopenic on admission. Bone marrow smear was positive for leishmania in 100% of the patients. All patients received treatment with liposomal amphotericin B. Conclusion: In certain regions, increased humidity rates associated with construction of dams and irrigation canals may lead to changes in the ecological balance and thus cause an increase in the population of disease-spreading vectors. Additionally, recent migration from the middle-eastern region to western parts of the world due to regional civil wars may have contributed to the observed increase in the incidence of various diseases such as VL.

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“…Unfortunately, the detailed history is not always readily available to pediatricians, particularly considering the incomplete expression and memory of young children. [ 18 ] In order to distinguish quickly parasite infection from other diseases in the patients with serous effusion and eosinophilia, reliable indicators are necessary. In this study, we analyzed the difference between parasitic group and non-parasitic group.…”

Section: Discussionmentioning

confidence: 99%

Distinguishment of parasite-infected children from pediatric inpatients with both eosinophilia and effusion

et al. 2020

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Patients with both serous effusion and eosinophilia are rarely reported and geographically distributed; their early diagnosis is difficult. According to the ultimate diagnosis, patients (≤14 years) in West China Second hospital with serous effusion and eosinophilia were divided into two groups including a parasitic group and a non-parasitic group. Clinical data were collected and analyzed between the two groups. Subsequently, significant measurement indicators were evaluated by receiver operating characteristic (ROC) curve to explore the optimal cut-off points for the most appropriate sensitivity and specificity. A total of 884 patients were diagnosed with serous effusion and 61 of them displayed co-morbidity with eosinophilia during enrolled time. Among 61 patients, 34 patients had parasitic infection and 27 had non-parasitic diseases. There were statistical difference in effusion position, the levels of white blood cell count (WBC), eosinophil (EOS), EOS%, C-reactive protein (CRP) between parasitic group and non-parasitic group. ROC curve demonstrated that the areas under the curve of EOS count and EOS% were >80%, and the corresponding optimal cut-off values were 1.71 × 10 9 /L and 25.6% for distinguishing between parasitic and non-parasitic infections in our patients. This study provided a quantified index for potentially quick and convenient indicators of pediatric patients presenting with both eosinophilia and effusion. Eosinophils were helpful to improve the initial diagnosis with awareness of parasitic diseases. For the cases with EOS > 1.71 × 10 9 /L or EOS% > 25.6%, parasitic infection should be considered and serological tests are recommended in our region.

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Clinical and Epidemiologic Features of Visceral Leishmaniasis in Children in Southwestern China

Cited by 11 publications

References 15 publications

Paediatric visceral leishmaniasis: a retrospective study on clinical manifestations, demographic features and laboratory findings of hospitalised cases in Iran between 2006 and 2016

Paediatric visceral leishmaniasis: a retrospective study on clinical manifestations, demographic features and laboratory findings of hospitalised cases in Iran between 2006 and 2016

Visceral Leishmaniasis in Children in Southern Turkey: Evaluation of Clinical and Laboratory Findings and Liposomal Amphotericin B Treatment

Distinguishment of parasite-infected children from pediatric inpatients with both eosinophilia and effusion

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