Clinical and Epidemiologic Phenotypes of Childhood Asthma

Abstract

Clinical phenotypes were well supported by LCA analysis. The hypothesis-free LCA phenotypes were a useful reference for comparing clinical phenotypes. Thereby, we identified children with clinically conspicuous but undiagnosed disease. Because of their high area under the curve values, clinical phenotypes such as (recurrent) unremitting wheeze emerged as promising alternative asthma definitions for epidemiologic studies.

The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21

“…In total, 983 individuals (i.e., 87% of the originally included 1,133 children) (6) were included in this analysis with 37,306 person-weeks of observation in the first year of life. In a subsample of 791 children (80.5%), single-nucleotide polymorphisms (SNPs) at the 17q21 asthma susceptibility locus, specifically SNP rs8076131 in the ORMDL3 gene and SNPs rs2290400 and rs7216389 in the GSDMB gene, were genotyped in cord blood as described before (6).…”

“…In a subsample of 791 children (80.5%), single-nucleotide polymorphisms (SNPs) at the 17q21 asthma susceptibility locus, specifically SNP rs8076131 in the ORMDL3 gene and SNPs rs2290400 and rs7216389 in the GSDMB gene, were genotyped in cord blood as described before (6). At the 6-year follow-up, data on asthma among 863 children (87.8%) were obtained.…”

“…Farming exposure has also been found to protect from early transient wheeze (5,6). This wheeze phenotype is triggered by viral infections and mostly disappears by age 3-4 years with the maturation of adaptive immunity.…”

Latent Class Models Identify Two Subphenotypes in Respiratory Distress Syndrome with Differential Response to Positive End-Expiratory Pressure

“…11 By contrast with traditional regression analyses, in which the goal is to understand the association between pre-specifi ed independent variables and a known outcome, latent class analysis models ask whether there are subgroups of patients defi ned by a combination of the baseline variables, without mandating consideration of the outcome. Latent class-based methods have been extensively used in the social sciences and in other medical disciplines, 12,13 for instance in the identifi cation of asthma subphenotypes, 14 but have not been used extensively in critical care. We sought to capitalise on the wealth of clinical and biological data available from two National Heart, Lung, and Blood Institute (NHLBI)-sponsored ARDS Network randomised controlled trials by using latent class analysis methods to attempt to identify and validate novel subphenotypes of ARDS and to test their association with clinical outcomes and response to treatment.…”

Asthma phenotypes in childhood: conceptual thoughts on stability and transition

“…wheeze", "early transient wheeze" or "late onset wheeze" [3][4][5][6]. Similarly we investigated symptoms of cough and wheeze at two time-points in the Leicestershire cohort studies and identified patterns such as "transient viral wheeze" and "atopic persistent wheeze" [7,8].…”