Clinical and epidemiologic variations of esophageal cancer in Tanzania

Gabel, Jaime V; Chamberlain, Robert M.; Ngoma, Twalib; Mwaiselage, Julius; Schmid, Kendra K.; Kahesa, Crispin; Soliman, Amr S.

doi:10.4251/wjgo.v8.i3.314

Cited by 21 publications

(33 citation statements)

References 15 publications

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“…In our study most of the EC cases were in males and showed 3.3-time associated risk of EC in male groups. Similar distribution were reported by study was conducted in Tanzania (15), an ecological study, which conducted based on GLOBOCAN project of World Health Organization (WHO) for Asian counters estimated that 70.33% incidence of EC cases in male and 29.87% in female (19). In addition, American Society of Cancer (20) and cancer research from United Kingdom (UK) countries reported the higher incidence of EC in male over female (21).…”

Section: Discussionsupporting

confidence: 70%

“…In our study the mean age of case groups was 59.4 years old compared to mean age of control (48 years). Study in India (14),Tanzania (15) and China (16) reported the majority of EC cases occurred in age group of > 60 years, > 65 years, and 60-69 years, respectively. Although EC occurs in the older age groups the lowest age for EC in the present study is 30 years.…”

Section: Discussionmentioning

confidence: 97%

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Socio-demographic risk factors of esophageal carcinoma: A case control study in a tertiary care hospital, Kabul Afghanistan

Saadaat¹,

Abdul‐Ghafar²,

Atta³

et al. 2020

Preprint

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Introduction Esophageal cancer (EC) is 7th most common cancer in world in term of incidence and 6th common cancer in term of mortality. In Afghanistan, EC is the most common cancer in males. The socio-demographic status has been known as associated factor for EC. We carried out this study to determine the associated risk factors with EC in a tertiary hospital in Kabul, Afghanistan. Methodology Unmatched case control study of socio-demographic risk factors and EC was conducted at French Medical Institute for Mother and Children (FMIC). We enrolled and analyzed 132 EC cases and 132 normal controls to find out the associated risk factors for EC Result In current study Esophageal Squamous Cell Carcinoma (ESCC) was the predominant EC type (75.8%). The mean age of the case group is 59.48 ± 9.9 years and in control group is 48.05 ± 11.02, (OR: 1.070, 95% CI, p-value <0.001). Majority of the cases group are male (69.6%) (OR: 3.538, 95% CI, p-value 0.022). Participants living in rural areas have the 25-times higher risk of EC than living in urban regions. Un-educated and lower education are highly associated with the risk of EC (OR: 11.21, 95% CI, p-value: <0.001) as well as, having low Socioeconomic status was also highly associated with the increased risk of EC (OR: 14.08, 95% CI, p-value: <0.001). Having family history in first degree family highly associated with the risk of EC (OR: 4.581, 95% CI, p-value <0.001). Although, the majority of the EC patients were unemployed (93.3%) of which 75% were farmer comparing to control which comprises 55.3% of unemployed statistically in multivariate analysis it showed no significant association with EC. In addition, living area according country zones and provinces, weight and height and ethnicity showed no significant association with EC. Conclusion The study concluded that EC is common cancer in older age groups and, predominance in males. In addition, living in rural areas, being un-educated or having lower education, belonging to low socioeconomic status, and having positive family history in first degree relatives are associated with high risk of EC in our study.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 97%

Socio-demographic risk factors of esophageal carcinoma: A case control study in a tertiary care hospital, Kabul Afghanistan

Saadaat¹,

Abdul‐Ghafar²,

Atta³

et al. 2020

Preprint

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“…Para outras populações, onde foi observada maior frequência de câncer de esófago entre os homens, de raça negra, com idade superior a 60 anos e de baixa escolaridade [6][7][8][9][17][18][19][20][21][22][23] . O consumo de tabaco e álcool também são mais frequentes nessa população, o que pode justificar a maior presença de câncer em pessoas com essas características 5,21 .…”

Section: Introductionunclassified

“…O consumo de álcool e tabaco, no momento do diagnóstico de câncer de esôfago, foi relatado pela maioria da população nesse estudo. Esses hábitos são conhecidos como importantes fatores de risco e de prognóstico do câncer de esôfago e em diferentes populações 7,[23][24] . Em outro estudo, 72% dos indivíduos com câncer de esôfago 27 .…”

Section: Introductionunclassified

“…Em outro estudo, 72% dos indivíduos com câncer de esôfago 27 . Nesse estudo, 91,6% dos casos de câncer de esôfago eram CCE, sendo esse o tipo histológico predominante no mundo 3,7,12,23 e no Brasil 15 . Entretanto, vários estudos vêm demonstrando declínio dos casos de CCE com consequente aumento dos casos de adenocarcinoma [3][4][5][6][7] , o que ocorre, provavelmente, pelo aumento da exposição aos fatores de risco, como a obesidade e o excesso de peso associados ao refluxo do ácido gástrico, consumo de tabaco e álcool 28 .…”

Section: Introductionunclassified

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Perfil dos Pacientes com Câncer de Esôfago Diagnosticados entre 2001 e 2010 no Brasil

Cruz

Pinto

Thuler

et al. 2018

Rev. Brasileira.De.Cancerologia

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Introdução: O câncer de esôfago é a terceira neoplasia mais comum do trato digestivo e apresenta prognóstico ruim quando diagnosticado em estádios avançados da doença. Objetivo: Descrever as características sociodemográficas, clínicas e de tratamento dos pacientes diagnosticados com câncer de esôfago no Brasil, no período de 2001 a 2010. Método: Estudo transversal de base secundária em pacientes com câncer de esôfago, cadastrados entre 2001 e 2010, nos Registros Hospitalares de Câncer. Foram analisadas as variáveis sociodemográficas, clínicas e de tratamento. Foi realizada análise descritiva utilizando média e desvio-padrão para as variáveis contínuas, e frequência absoluta e relativa para as categóricas. Resultados: Foram incluídos 24.204 pacientes, com média de idade de 60,8 anos (±11,5). A maioria da população era do sexo masculino (78,3%), de baixa escolaridade (75,2%), etilista (62,9%), tabagista (76,0%) e com estádio avançado ao diagnóstico (41,3% em estádio clínico III e 26,9%, IV), sendo o grupo topográfico de maior prevalência o esôfago superior e médio (76,4%). Não foram submetidos a nenhum tratamento oncológico 12,7% dos pacientes. Os tratamentos mais frequentes foram a combinação entre radioterapia e quimioterapia (25,6%), e o tratamento isolado com radioterapia (21,9%). Ao final do primeiro tratamento oncológico, 10,7% estavam sem evidência de doença, 8,4% com remissão parcial, 26,6% com doença estável e, os demais, com doença em progressão ou óbito (54,4%). Conclusão: No Brasil, os casos diagnosticados por câncer de esôfago são, em sua maioria, diagnosticados em estádios avançados da doença, o que representou maior agressividade terapêutica e pior resposta ao tratamento.

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Exploring Oesophageal Cancer in Ethiopia: Elevated Incidence in Females and Younger Cases

Mulisa,

Abebe,

Gutema

et al. 2024

Cancer Reports

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BackgroundOesophageal cancer is a public health concern in Ethiopia. Identifying the incidence and demographic profile of the two histological subtypes: oesophageal squamous cell carcinoma (ESCC) and oesophageal adenocarcinoma (EAC) are the key steps in recognizing the disease burden and potential aetiopathological associations.AimThe aim of this study is to identify the age and gender‐specific incidence patterns of the most common subtype of oesophageal cancer in a high‐incidence area of Ethiopia.MethodsA retrospective cross‐sectional study from a high‐incidence oesophageal cancer district in Ethiopia identified 630 cases from the pathology registry of nine hospitals. The patient records were carefully reviewed and data on age, gender, tumour location and histological types was systematically compiled. The patient data were retrieved and descriptive statistics were used to generate results.ResultsESCC subtype, accounted for constituting 500 (79.437%) cases. A gender disparity was observed, with 62.80% of cases occurring in females and 37.20% in males. This distribution of higher female ESCC incidences aligns with previous findings indicating a regional consistency and probable aetiological factor. Furthermore, ESCC incidence peaked at 40–50 years in females, highlighting an age‐related incidence trend. EAC was observed in 67 (51.5%) females and 63 (48.5%) males showing similar prevalence. Spatial analysis revealed that the majority of ESCC cases were located in the lower oesophagus, followed by the middle part, with fewer instances in the upper oesophagus.ConclusionThis study from Ethiopia identified ESCC as the predominant subtype, with a marked female predominance and age‐related gender disparities. EAC with a lesser proportion identified with consistent spatial distribution patterns in both genders provide valuable insights into the epidemiological landscape of this disease. These findings emphasize the urgency of targeted research to uncover the underlying factors.

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Clinical and epidemiologic variations of esophageal cancer in Tanzania

Cited by 21 publications

References 15 publications

Socio-demographic risk factors of esophageal carcinoma: A case control study in a tertiary care hospital, Kabul Afghanistan

Socio-demographic risk factors of esophageal carcinoma: A case control study in a tertiary care hospital, Kabul Afghanistan

Perfil dos Pacientes com Câncer de Esôfago Diagnosticados entre 2001 e 2010 no Brasil

Exploring Oesophageal Cancer in Ethiopia: Elevated Incidence in Females and Younger Cases

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