Clinical and epidemiological features of Turkish children with 2009 pandemic influenza A (H1N1) infection: Experience from multiple tertiary paediatric centres in Turkey

Çıftçı, Ergın; Tuygun, Nilden; Özdemir, Halil; Tezer, Hasan; Şensoy, Gülnar; Devrim, İlker; Dalgıç, Nazan; Kara, Ateş; Turğut, Mehmet; Tapisiz, Anıl; Keser, Melike; Çelebi, Solmaz; Bayram, Nuri; Kocabaş, Emine; Dinleyici, Ener Çağrı; Özen, Metehan; Soysal, Ahmet; Kuyucu, Necdet; Tanır, Gönül; Çelikel, Elif; Belet, Nurşen; Evren, Gültaç; Aytaç, Didem Büyüktaş; Cengiz, Ali Bülent; Canöz, Perihan Yasemen; Derinöz, Okşan; İnce, Erdal; Hacımustafaoğlu, Mustafa; Anıl, Murat; Özgür, Özlem; Kuzdan, Canan; Özaydın, Eda; Asilioglu, Nazik; Dizdarer, Ceyhun; Ceyhan, Mehmet; Bucak, İbrahim Hakan; Kendirli, Tanıl; Yakut, Halil İbrahim; Fışgın, Tunç; Ünal, Nurettin; Altindağ, Hakan; Kılınç, Ayşe Ayzıt; Zöhre, Seray Umut; Elhan, Atilla Halil; Doğru, Ülker

doi:10.3109/00365548.2011.598872

Cited by 25 publications

(37 citation statements)

References 14 publications

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“…Our pandemic hospitalization data showed similarities with other countries: the median age (5 years) of children hospitalized was similar to that found in large studies in Canada and Korea, but slightly lower than that found in Japan [18][19][20]. There were more males than females hospitalized in Ireland during the pandemic, as was found in many other studies [19,27,28]. 43% in Germany, and 42% of cases in Australia [5,21], but in line with or higher than other large populationbased studies (32% in the USA, 27·5% in Madrid and 22·4% in Korea) [6,22,23].The proportion of hospitalized children requiring PICU admission was low at 5% when compared with that found in Canada and Argentina at 16·8% and 19% respectively, but similar to Australia at 4·6% [6,21,24,25].…”

Section: Discussionsupporting

confidence: 88%

Influenza in hospitalized children in Ireland in the pandemic period and the 2010/2011 season: risk factors for paediatric intensive-care-unit admission

et al. 2013

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Influenza causes significant morbidity and mortality in children. This study's objectives were to describe influenza A(H1N1)pdm09 during the pandemic, to compare it with circulating influenza in 2010/2011, and to identify risk factors for severe influenza defined as requiring admission to a paediatric intensive care unit (PICU). Children hospitalized with influenza during the pandemic were older, and more likely to have received antiviral therapy than children hospitalized during the 2010/2011 season. In 2010/2011, only one child admitted to a PICU with underlying medical conditions had been vaccinated. The risk of severe illness in the pandemic was higher in females and those with underlying conditions. In 2010/2011, infection with influenza A(H1N1)pdm09 compared to other influenza viruses was a significant risk factor for severe disease. An incremental relationship was found between the number of underlying conditions and PICU admission. These findings highlight the importance of improving low vaccination uptake and increasing the use of antivirals in vulnerable children.

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Section: Discussionsupporting

confidence: 88%

Influenza in hospitalized children in Ireland in the pandemic period and the 2010/2011 season: risk factors for paediatric intensive-care-unit admission

et al. 2013

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“…The most common symptoms at presentation are reported as fever, cough and respiratory problems in most reports . Similarly, in our study, fever and cough were the most common clinical signs (85.7%), followed by fatigue (57%).…”

Section: Discussionsupporting

confidence: 82%

“…from Canada but more than Çiftçi et al . from Turkey . Digestive symptoms tend to be more common than seasonal influenza infection, which is detected as 23.8% diarrhea and 38% as vomiting in our study .…”

Section: Discussionmentioning

confidence: 43%

Efficacy of intravenous immunoglobulin treatment in immunocompromised children with H1N1 influenza: a clinical observation

Göktürk¹,

Pekcan

Güner

et al. 2014

Clinical Respiratory J

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“…The majority of admitted children (56.9%) were younger than 5 y of age, and 35 children (4.3%) died. The death rate was significantly higher in patients with malignancy, chronic neurological disease, immunosuppressive therapy, at least 1 pre-existing condition, or respiratory complications [11]. …”

Section: Discussionmentioning

confidence: 99%

Predictors of fatality in pandemic influenza A (H1N1) virus infection among adults

Ergönül

Alan

et al. 2014

BMC Infect Dis

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BackgroundThe fatality attributed to pandemic influenza A H1N1 was not clear in the literature. We described the predictors for fatality related to pandemic influenza A H1N1 infection among hospitalized adult patients.MethodsThis is a multicenter study performed during the pandemic influenza A H1N1 [A(H1N1)pdm09] outbreak which occurred in 2009 and 2010. Analysis was performed among laboratory confirmed patients. Multivariate analysis was performed for the predictors of fatality.ResultsIn the second wave of the pandemic, 848 adult patients were hospitalized because of suspected influenza, 45 out of 848 (5.3%) died, with 75% of fatalities occurring within the first 2 weeks of hospitalization. Among the 241 laboratory confirmed A(H1N1)pdm09 patients, the case fatality rate was 9%. In a multivariate logistic regression model that was performed for the fatalities within 14 days after admission, early use of neuraminidase inhibitors was found to be protective (Odds ratio: 0.17, confidence interval: 0.03-0.77, p = 0.022), nosocomial infections (OR: 5.7, CI: 1.84-18, p = 0.013), presence of malignant disease (OR: 3.8, CI: 0.66-22.01, p = 0.133) significantly increased the likelihood of fatality.ConclusionsEarly detection of the infection, allowing opportunity for the early use of neuraminidase inhibitors, was found to be important for prevention of fatality. Nosocomial bacterial infections and underlying malignant diseases increased the rate of fatality.

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Clinical and epidemiological features of Turkish children with 2009 pandemic influenza A (H1N1) infection: Experience from multiple tertiary paediatric centres in Turkey

Abstract: In Turkey, 2009 H1N1 infection caused high mortality and PICU admission due to severe respiratory illness and complications, especially in children with an underlying condition.

Cited by 25 publications

References 14 publications

Influenza in hospitalized children in Ireland in the pandemic period and the 2010/2011 season: risk factors for paediatric intensive-care-unit admission

Influenza in hospitalized children in Ireland in the pandemic period and the 2010/2011 season: risk factors for paediatric intensive-care-unit admission

Efficacy of intravenous immunoglobulin treatment in immunocompromised children with H1N1 influenza: a clinical observation

Predictors of fatality in pandemic influenza A (H1N1) virus infection among adults

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