Clinical and epidemiological profiles including meteorological factors of low respiratory tract infection due to human rhinovirus in hospitalized children

Abstract

BackgroundLower respiratory tract infection (LRTI) is a major cause of morbidity and mortality in children. Human rhinovirus (HRV) is confirmed to be associated with pediatric lower respiratory tract infection. Seasonal and meteorological factors may play a key role in the epidemiology of HRV. The purposes of this study were to investigate the frequency, seasonal distribution, and clinical characteristics of hospitalized children with LRTI caused by HRVs. In addition, associations between incidence of HRVs and meteorological factors in a subtropical region of China were discussed.MethodsHospitalized children <14 years old admitted to the Respiratory Department of the Children’s Hospital, which is affiliated to Soochow University, between January 1, 2013 and December 31, 2015, were enrolled in this study. Multi-pathogens were detected in nasopharyngeal aspirate samples. Meanwhile, meteorological factors were recorded.ResultsThe average incidence of HRVs infection was 11.4% (707/6194) and 240 cases of which were co-infection cases with other pathogens. Children with co-infection presented more frequent fever and tachypnea compared to children infected with HRVs only (both P < 0.05). Among 707 HRV positive children, the mean age was 23.2 months (range 1 to 140 months). Among all respiratory infections, the highest incidence of HRVs cases occurred in children age 13–36 months old (15.1%, 203/1341). Of all 228 HRV cases in 2014, 85 cases (37.3%) were HRV-C positive. HRVs and HRV-C infection occurred throughout the year during the study period, although a higher incidence was observed in summer and autumn seasons. HRVs or HRV-C incidence in hospitalized children with LRTI was associated with the monthly mean temperature (both P < 0.05).ConclusionHRV was one of the most common viral pathogen detected in hospitalized children with LRTI at the Children’s Hospital of Suzhou, China, and had its own seasonal distribution including HRV-C, which was partly caused by temperature.

High genotypic diversity of Rhinoviruses obtained from Tunisian children with severe acute respiratory infection

“…Morocco (November 2010-December 2011) [23]. At the same time, present results are similar to results obtained from January 2009 to March 2010 in the south of Tunisia [18] and in others studies targeting subtropical and western regions of China [24,25] or also in Jordan [26]. These differences in detection rates may be explained by: i) the specificity of the used assay which may lead to false positive detection; ii) the epidemiological and demographic variabilities from a region to another.…”

The spectrum of viral pathogens in children with severe acute lower respiratory tract infection: A 3‐year prospective study in the pediatric intensive care unit

“…HRV isolates were detected each month of the year, and the highest positive rates were in September. This result was consistent with that of a previous study in Suzhou, but different from that of a study in Changsha . The possible explanation for this difference was that the predominant species of HRV varies from location to location and year to year.…”

Circulating Pattern of Respiratory Viruses, in Egypt, Season 2013-2014

“…Highest co-infection rate was found with RSV in 4 cases (10.8%). This finding is concurrent with other reports 44 . Following the RSV in number of co-infection, was the hMPV with 3 co-infection cases (8.9%), in which two cases from them (66%) were paediatrics admitted to the ICU.…”