Clinical and experimental approaches for imaging of acute kidney injury

Katagiri, Daisuke; Wang, Feng; Gore, John C.; Harris, Raymond C.; Takahashi, Takamune

doi:10.1007/s10157-021-02055-2

Cited by 9 publications

(17 citation statements)

References 165 publications

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“…Depending mainly on tissue composition, PSR is less affected by renal function and physiological conditions 56 . By contrast,

{R_{2}}^{*}

increases after IRI because this measure is most sensitive to renal hemodynamic changes, including blood flow and capillary density reduction 8,57 . In the CR of IRI kidneys, PSR and relaxometry measures such as

R_{1}

R_{1 ρ}

, and

R_{2}

decreased, possibly due to TA.…”

Section: Discussionmentioning

confidence: 99%

“…Previous IRI studies also exhibited these pathological changes in the cortical regions of injured kidneys. 8,46 Because TA and fibrosis are the predominant histopathological characteristics at this stage after IRI, the indices TA, FS, and TA + F were quantified.…”

Section: Renal Histopathology Of Iri Kidneysmentioning

confidence: 99%

“…Depending mainly on tissue composition, PSR is less affected by renal function and physiological conditions. 56 By contrast, R 2 Ã increases after IRI because this measure is most sensitive to renal hemodynamic 8,57 In the CR of IRI kidneys, PSR and relaxometry measures such as R 1 , R 1ρ , and R 2 decreased, possibly due to TA. Only R 2 Ã increased, which might be due to reduction of RBF and tissue oxygenation level.…”

Section: Elucidation Of Exceptional Changes Of Mri Measures In Iri Ki...mentioning

confidence: 99%

“…Currently, renal biopsy is still limited in clinical practice. Even though several urinary biomarkers have been identified, there are limitations in using these markers to assess pathological changes after AKI, including the extent of renal fibrosis or tubular atrophy (TA) 8 . Thus, it would be essential to develop a robust imaging method with sufficient specificity and sensitivity for assessing kidney status and identifying patients at high risk for CKD progression 9–11 …”

Section: Introductionmentioning

confidence: 99%

“…Magnetic resonance imaging (MRI) can provide measurements to estimate the temporal and spatial progression of structural, functional, and metabolic alterations in kidneys caused by various injuries and diseases 12–19 . Several MRI techniques have been explored for their potential for detecting AKI‐induced kidney disease, 8,18 including diagnosis of renal structural abnormalities, 20 detection of urinary tract obstruction, 4,21 evaluation of tissue microstructure, 22–24 assessment of renal perfusion and oxygenation, 19,22–25 estimation of apoptosis or fibrosis, 26 and quantification of the whole kidney volume 26 . However, a limited number of MRI measures could not provide a thorough estimate of renal structure, composition, and function during disease progression.…”

Section: Introductionmentioning

confidence: 99%

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Multiparametric magnetic resonance imaging in diagnosis of long‐term renal atrophy and fibrosis after ischemia reperfusion induced acute kidney injury in mice

et al. 2022

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Tubular atrophy and fibrosis are pathological changes that determine the prognosis of kidney disease induced by acute kidney injury (AKI). We aimed to evaluate multiple magnetic resonance imaging (MRI) parameters, including pool size ratio (PSR) from quantitative magnetization transfer, relaxation rates, and measures from spin‐lock imaging ( R1ρ and Sρ), for assessing the pathological changes associated with AKI‐induced kidney disease. Eight‐week‐old male C57BL/6 J mice first underwent unilateral ischemia reperfusion injury (IRI) induced by reperfusion after 45 min of ischemia. They were imaged using a 7T MRI system 56 days after the injury. Paraffin tissue sections were stained using Masson trichrome and picrosirius red to identify histopathological changes such as tubular atrophy and fibrosis. Histology detected extensive tubular atrophy and moderate fibrosis in the cortex and outer stripe of the outer medulla (CR + OSOM) and more prominent fibrosis in the inner stripe of the outer medulla (ISOM) of IRI kidneys. In the CR + OSOM region, evident decreases in PSR, R1, R2, R1ρ, and Sρ showed in IRI compared with contralateral kidneys, with PSR and Sρ exhibiting the most significant changes. In addition, the exchange parameter Sρ dropped by the largest degree among all the MRI parameters, while R2* increased significantly. In the ISOM of IRI kidneys, PSR increased while Sρ kept decreasing. R2, R1ρ, and R2* all increased due to more severe fibrosis in this region. Among MRI measures, PSR and R1ρ showed the highest detectability of renal changes no matter whether tubular atrophy or fibrosis dominated. R2* and Sρ could be more specific to a single pathological event than other MRI measures because only R2* increased and Sρ decreased consistently when either fibrosis or tubular atrophy dominated, and their correlations with fibrosis scores were higher than other MRI measures. Multiparametric MRI may enable a more comprehensive analysis of histopathological changes following AKI.

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“…Depending mainly on tissue composition, PSR is less affected by renal function and physiological conditions 56 . By contrast,

{R_{2}}^{*}

R_{1}

R_{1 ρ}

, and

R_{2}

decreased, possibly due to TA.…”

Section: Discussionmentioning

confidence: 99%

Section: Renal Histopathology Of Iri Kidneysmentioning

confidence: 99%

Section: Elucidation Of Exceptional Changes Of Mri Measures In Iri Ki...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multiparametric magnetic resonance imaging in diagnosis of long‐term renal atrophy and fibrosis after ischemia reperfusion induced acute kidney injury in mice

et al. 2022

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Severity of polycystic kidney disease revealed by multiparametric MRI

Wang

Lee

Adelnia

et al. 2023

Magnetic Resonance in Med

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Purpose We aimed to compare multiple MRI parameters, including relaxation rates (R1$$ {R}_1 $$, R2$$ {R}_2 $$, and R1ρ$$ {R}_{1\rho } $$), ADC from diffusion weighted imaging, pool size ratio (PSR) from quantitative magnetization transfer, and measures of exchange from spin‐lock imaging (Sρ$$ {S}_{\rho } $$), for assessing and predicting the severity of polycystic kidney disease (PKD) over time. Methods Pcy/Pcy mice with CD1 strain, a mouse model of autosomal dominant PKD, were imaged at 5, 9, and 26 wk of age using a 7T MRI system. Twelve‐week normal CD1 mice were used as controls. Post‐mortem paraffin tissue sections were stained using hematoxylin and eosin and picrosirius red to identify histological changes. Results Histology detected segmental cyst formation in the early stage (week 5) and progression of PKD over time in Pcy kidneys. In T2$$ {T}_2 $$‐weighted images, small cysts appeared locally in cystic kidneys in week 5 and gradually extended to the whole cortex and outer stripe of outer medulla region from week 5 to week 26. Regional PSR, R1$$ {R}_1 $$, R2$$ {R}_2 $$, and R1ρ$$ {R}_{1\rho } $$ decreased consistently over time compared to normal kidneys, with significant changes detected in week 5. Among all the MRI measures, R2$$ {R}_2 $$ and R1ρ$$ {R}_{1\rho } $$ allow highest detectability to PKD, while PSR and R1$$ {R}_1 $$ have highest correlation with pathological indices of PKD. Using optimum MRI parameters as regressors, multiple linear regression provides reliable prediction of PKD progression. Conclusion R2$$ {R}_2 $$, R1$$ {R}_1 $$, and PSR are sensitive indicators of the presence of PKD. Multiparametric MRI allows a comprehensive analysis of renal changes caused by cyst formation and expansion.

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A Comparative Study of 18F-FAPI-42 and 18F-FDG PET/CT for Evaluating Acute Kidney Injury in Cancer Patients

Chi

Yang

et al. 2023

Mol Imaging Biol

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Clinical and experimental approaches for imaging of acute kidney injury

Cited by 9 publications

References 165 publications

Multiparametric magnetic resonance imaging in diagnosis of long‐term renal atrophy and fibrosis after ischemia reperfusion induced acute kidney injury in mice

Multiparametric magnetic resonance imaging in diagnosis of long‐term renal atrophy and fibrosis after ischemia reperfusion induced acute kidney injury in mice

Severity of polycystic kidney disease revealed by multiparametric MRI

A Comparative Study of 18F-FAPI-42 and 18F-FDG PET/CT for Evaluating Acute Kidney Injury in Cancer Patients

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