Clinical and Experimental Effectiveness of Astragali Compound in the Treatment of Chronic Viral Hepatitis B

Tang, Leilei; Sheng, Jianpeng; Ch, Xu; Kz, Liu

doi:10.1177/147323000903700308

Cited by 31 publications

(20 citation statements)

References 12 publications

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“…Recently, various studies on the effects of Radix Astragali on obesity-related metabolic disorders have been carried out [31,32]. The extracts of Radix Astragali have been shown to be anti-inflammatory [33], hepatoprotective [34], cardioprotective [35], neuroprotective [36,37] and anti-diabetic [38].…”

Section: Discussionmentioning

confidence: 99%

The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity

et al. 2010

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BackgroundMacrophage infiltration in adipose tissue together with the aberrant production of pro-inflammatory cytokines has been identified as the key link between obesity and its related metabolic disorders. This study aims to isolate bioactive ingredients from the traditional Chinese herb Radix Astragali (Huangqi) that alleviate obesity-induced metabolic damage through inhibiting inflammation.MethodsActive fraction (Rx) that inhibits pro-inflammatory cytokine production was identified from Radix Astragali by repeated bioactivity-guided high-throughput screening. Major constituents in Rx were identified by column chromatography followed by high-performance liquid chromatography (HPLC) and mass-spectrometry. Anti-diabetic activity of Rx was evaluated in db/db mice.ResultsTreatment with Rx, which included calycosin-7-β-D-glucoside (0.9%), ononin (1.2%), calycosin (4.53%) and formononetin (1.1%), significantly reduced the secretion of pro-inflammatory cytokines (TNF-α, IL-6 and MCP-1) in human THP-1 macrophages and lipopolysaccharide (LPS)-induced activation of NF-κB in mouse RAW-Blue macrophages in a dose-dependent manner. Chronic administration of Rx in db/db obese mice markedly decreased the levels of both fed and fasting glucose, reduced serum triglyceride, and also alleviated insulin resistance and glucose intolerance when compared to vehicle-treated controls. The mRNA expression levels of inflammatory cell markers CD68 and F4/80, and cytokines MCP-1, TNF-α and IL-6 were significantly reduced in epididymal adipose tissue while the alternatively activated macrophage marker arginase I was markedly increased in the Rx-treated mice.ConclusionThese findings suggest that suppression of the inflammation pathways in macrophages represents a valid strategy for high-throughput screening of lead compounds with anti-diabetic and insulin sensitizing properties, and further support the etiological role of inflammation in the pathogenesis of obesity-related metabolic disorders.

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Section: Discussionmentioning

confidence: 99%

The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity

et al. 2010

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“…In 2010 Tang et al reported that the proportion of negative seroconversion of HBeAg was significantly higher and the HBV DNA level was significantly lower in the Astragali group than in the control group, indicating that Astragali inhibited replication of HBV. 26 Liu et al found in 2005 that ALT and AST significantly improved after 24 weeks of treatment with fuzheng huayu capsules. 27 That study was a randomized, controlled, double-blind trial conducted in China that enrolled 216 patients with chronic hepatitis B and fibrosis.…”

Section: Discussionmentioning

confidence: 98%

A Chinese Medicine, Kuan-Sin-Yin Decoction, Improves Liver Function in Hepatitis B Virus Carriers: A Randomized, Controlled Study

Lee

Cheng

et al. 2013

The Journal of Alternative and Complementary Medicine

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“…Chinese herbs have been demonstrated recently to possess some advantages in the therapy of anti-HBV. For instance, HBeAg and HBV DNA are under negative seroconversions in chronic hepatitis B patients treated by Radix astragali , one of the herbs in SHYGC [13]. Radix scutellariae , another herb of SHYGC, suppresses both wild-type HBV and lamivudine-resistant mutated HBV gene expression and virus production in human hepatoma cells [14].…”

Section: Discussionmentioning

confidence: 99%

Study on the antiviral activity of San Huang Yi Gan Capsule against hepatitis B virus with seropharmacological method

Qing-he

Peng

et al. 2013

BMC Complement Altern Med

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BackgroundSeropharmacology arising recently is a novel method of in vitro pharmacological study on Chinese herb using drug-containing animal serum. As seropharmacology possesses the advantages of experiments in vitro and in vivo, it is increasingly applied in pharmacological research on Chinese medicine. However, some issues of seropharmacology remain controversial and need to be clearly defined. San Huang Yi Gan Capsule (SHYGC) is a Chinese herbal formula with antiviral property against hepatitis B virus (HBV), but little is known about the mechanism underlying its anti-HBV activity. The aim of the present study was to elucidate the action mechanism of SHYGC using seropharmacological method and systematically address the methodology of preparing drug-containing serum.MethodsNew Zealand rabbits were orally administrated SHYGC with various regimens, followed by preparation of SHYGC-containing rabbit sera with a variety of methods. After HBV-producing HepG2 2.2.15 cells were treated with SHYGC-containing sera or entecavir for 9 days, the levels of hepatitis B surface antigen (HBsAg) and HBV DNA and the activity of DNA Polymerase were determined in HepG2 2.2.15 cells-conditioned media.ResultsAn optimally standardized method of preparing drug-containing serum was raised for seropharmacology, with which SHYGC was demonstrated to suppress HBsAg expression, HBV DNA replication and DNA Polymerase activity in a dose-dependent fashion.ConclusionsThis seropharmacological study shows SHYGC is a potentially powerful anti-HBV agent. Additionally, seropharmacology is a promising pharmacological method with a broad range of advantages, and it can be widely used in biomedical research, if combined with pharmacokinetics.

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Clinical and Experimental Effectiveness of Astragali Compound in the Treatment of Chronic Viral Hepatitis B

Cited by 31 publications

References 12 publications

The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity

The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity

A Chinese Medicine, Kuan-Sin-Yin Decoction, Improves Liver Function in Hepatitis B Virus Carriers: A Randomized, Controlled Study

Study on the antiviral activity of San Huang Yi Gan Capsule against hepatitis B virus with seropharmacological method

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