Clinical and Follow-Up Studies of Melanocytomas of the Optic Disc

Joffe, Leonard; Shields, Jerry A.; Osher, Robert H.; Gass, J. Donald M.

doi:10.1016/s0161-6420(79)35421-5

Cited by 112 publications

(72 citation statements)

References 11 publications

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“…1 Melanocytomas of the optic disc typically appear as an elevated dark brown or black lesion, which occupies part or occasionally the entire optic disc. 4 Melanocytomas usually extend over the edage of the optic disc and in about half the cases appear to have an associated contiguous choroidal naevus 12 which is merely an extension of the melanocytoma beneath the juxtapapillary retinal pigment epithelium.…”

Section: Discussionmentioning

confidence: 99%

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Large optic disc melanocytoma: A rare entity

2015

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Optic disc melanocytoma is a deeply pigmented variant of benign melanocytic nevus thathas been confused with malignant melanoma. Optic disc melanocytomas are locally invasivebut are not known to undergo transformation into malignant melanoma. We present anunusual case of a melanocytoma of the optic disc that is a coincidental fi nding on routinefundus examination even though the size of the melanocytoma is quiet large around 2.5 DD(3.7 mm) in size (while usually mean tumour diameter is 2 mm only) Follow up should remainthe primary approach in the management of the patients with optic nerve melanocytomasas they are benign, as previously advocated by Zimmerman. DOI: http://dx.doi.org/10.3126/ajms.v6i5.11560 Asian Journal of Medical Sciences Vol.6(5) 2015 78-81

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Section: Discussionmentioning

confidence: 99%

“…Joffe etal evaluated 27 cases of optic disc melanocytoma and an increase In size in four (15%) cases. 12 Apple et al 15 described the first case of malignant transformation of an optic nerve melanocytoma. Shields etal recently documented that the rate of malignant transformation is approximatedly 1-2%.…”

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confidence: 99%

Large optic disc melanocytoma: A rare entity

2015

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Section: Quadro Clínicounclassified

“…Em 60% dos casos não excedem um diâmetro de disco óptico, contudo há registro de uma lesão de tamanho de seis diâmetros de papila (26) . Joffe et al (26) avaliaram diversos tipos de apresentação clínica do melanocitoma em 40 pacientes. Eles encontraram a lesão confinada à cabeça do nervo óptico em 18% dos pacientes, estendendo nas camadas de fibras nervosas da retina em 77%, apresentando um componente coroidal justapapilar em 47% e demonstrou mínimo crescimento em 15%.…”

Section: Quadro Clínicounclassified

“…Foram relatados alguns casos raros de associações oculares, embora consideradas prováveis coincidên-cias, tais como melanose racial, hipoplasia do disco óptico, retinose pigmentar, hipertrofia congênita do epitélio pigmentar da retina, neurofibromatose tipo dois, carcinoma basocelular (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28) .…”

Section: Quadro Clínicounclassified

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Melanocitoma do nervo óptico

Gouveia¹,

Morales²

2008

Rev. bras.oftalmol.

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RESUMOO melanocitoma do disco óptico é bem conhecido como uma variante do nervo melanocítico que geralmente ocorre no disco óptico. Historicamente o tumor foi confundido com melanoma maligno. Histopatologicamente é composto por células redondas densamente pigmentadas com citoplasma abundante e pequenos nucléolos. O melanocitoma é considerado um tumor benigno, estacionário e com pouca predisposição de sofrer malignação. Na maioria dos casos são assintomáticos, mas podem apresentar defeitos pupilares e no campo visual. É importante salientar que a transformação maligna em melanoma ocorre em 1 a 2% dos casos. Assim, os oftalmologistas devem familiarizar-se com o melanocitoma do disco óptico e os pacientes afetados devem ser acompanhados periodicamente.Descritores: Melanoma/diagnóstico; Disco óptico/patologia; Neoplasias do nervo óptico/ pathology; Melanócitos/patologia; Diagnóstico diferencial; Revisão

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Uveal Melanocytomas

Fogt

Selim²,

Xu³

et al. 2005

Arch Ophthalmol

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Objective: Melanocytomas of the eye are typically benign tumors that may be associated with nevi and melanomas. In this study, we assessed the genetic data of melanocytomas and compared them with nevi and melanomas of both the eyes and the skin.Design: We microdissected 8 melanocytomas, 13 uveal melanomas, and 10 cutaneous melanomas and analyzed loss of heterozygosity markers on chromosome bands 1p36, 6q22-23.3, 9p21, and 10q23, which represent genetic loci associated with advanced dermal melanocytic lesions.Results: There was no loss of heterozygosity in any of the melanocytomas. However, many loss of heterozygosity events were found in uveal and cutaneous mela-nomas, most frequently involving chromosome 1 damage followed by chromosome 9 and 10 alterations.Conclusion: Based on the absence of loss of heterozygosity in melanocytomas, specifically the locus that is lost most often in dysplastic nevi of the skin, we conclude that melanocytomas represent an entity that is different from melanomas or may be similar to that of dermal benign nevi.Clinical Relevance: Our results confirm that melanocytomas represent nonagressive lesions that do not demand radical surgery.

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Clinical and Follow-Up Studies of Melanocytomas of the Optic Disc

Cited by 112 publications

References 11 publications

Large optic disc melanocytoma: A rare entity

Large optic disc melanocytoma: A rare entity

Melanocitoma do nervo óptico

Uveal Melanocytomas

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