Clinical and functional outcome of total hip arthroplasty in patients with acromegaly: mean twelve year follow-up

Akkaya, Mustafa; Pignataro, Antonio; Sandiford, Nemandra A; Gehrke, Thorsten; Citak, Mustafa

doi:10.1007/s00264-022-05447-5

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…Currently, the number of papers concerning the orthopedic treatment of OA in acromegaly is scarce and those are mostly limited to a series of case reports. Regarding hip OA in acromegaly, total hip arthroplasty seems to be a promising option [57]. It should be noted, however, that none of the treatment strategies have been formally studied in acromegaly.…”

Section: B Amentioning

confidence: 99%

Skeletal complications in acromegaly

Wydra,

Stelmachowska-Banaś,

Czajka-Oraniec

2023

Reumatologia

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Hypersecretion of growth hormone (GH) is rare and typically results from a pituitary functional tumor – somatotropinoma. It leads to excessive linear bone growth and manifests as gigantism if occurring in childhood and adolescence, before the closure of epiphyses or as a acromegaly in adulthood. The excess of GH impacts bone metabolism directly as well as indirectly through increased insulin-like growth factor 1 (IGF-1). In acromegaly as a consequence of overproduction of GH and IFG-1 and the influence of these hormones on bone osteoblasts, bone metabolism, growth and density increase. However, bone turnover is accelerated causing impaired bone microstructure and strength, which may lead to increased risk of vertebral fractures irrespective of normal bone mineral density. Apart from the changes in bone architecture, acromegaly also results in a degenerative joint disease of a different nature than primary osteoarthritis. Moreover, acromegaly leads to cardiovascular, metabolic and respiratory complications, and thus significantly impairs the quality of life. In this review, authors summarize the pathophysiology, diagnosis, and treatment of bone and joint disease in acromegaly.

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Section: B Amentioning

confidence: 99%

Skeletal complications in acromegaly

Wydra,

Stelmachowska-Banaś,

Czajka-Oraniec

2023

Reumatologia

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Approach to the patient with controlled acromegaly and acromegalic arthropathy: clinical diagnosis and management

Pelsma,

Kroon,

Andela

et al. 2024

Pituitary

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Following the description of an illustrative case of a 70-year-old female patient with longstanding active acromegaly and invalidating, progressive joint complaints, current insights regarding diagnosis, treatment, and long-term management of acromegalic arthropathy are summarized. Since clinical trials on this topic are lacking, the reported recommendations are based on extensive clinical and research experience with this clinical entity, and on established diagnostics and interventions in patients with other rheumatic diseases. The cornerstones of the management of acromegalic arthropathy remains normalization of growth hormone and insulin growth factor-1 levels. However, patients with severe or progressive acromegalic arthropathy require a multidisciplinary approach to determine adequate diagnostics and treatment options. Because of the high prevalence and invalidating character of acromegalic arthropathy, developing evidence-based effective prevention and treatment strategies, preferably by international collaboration within rare disease networks, e.g., Endo-ERN, is a clear unmet need.

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