2012
DOI: 10.1002/path.4034
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Clinical and functional significance of loss of caveolin‐1 expression in breast cancer‐associated fibroblasts

Abstract: Loss of caveolin-1 (Cav-1) expression in breast cancer-associated fibroblasts (CAFs) is predictive of poor prognosis in breast cancer, but its function has not been established. Our study tested the hypotheses that loss of Cav-1 expression in breast fibroblasts was associated with poor prognosis in breast cancer, through promotion of breast cancer cell invasion. Cav-1 stromal expression was immunohistochemically assessed in 358 breast cancers. Cav-1 expression in primary breast fibroblasts was analysed by west… Show more

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Cited by 92 publications
(88 citation statements)
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“…8,10 In this regard, the prognostic value of a loss of stromal caveolin-1 (Cav-1; indicative of glycolysis and autophagy in the tumor microenvironment) has now been independently validated in seven different countries, and its predictive capacity has also been extended to DCIS progression, human prostate cancers and metastatic melanoma. 8,10,[35][36][37][38][39][40][41] In addition, the expression of stromal MCT4 appears to inversely correlate with stromal Cav-1, allowing them to be used together as companion diagnostics for the detection of "two-compartment tumor metabolism." 31 However, in addition to these stromal diagnostics, new epithelial biomarkers are desperately needed to identify the corresponding onset of mitochondrial biogenesis in human breast cancer cells.…”
Section: Resultsmentioning
confidence: 99%
“…8,10 In this regard, the prognostic value of a loss of stromal caveolin-1 (Cav-1; indicative of glycolysis and autophagy in the tumor microenvironment) has now been independently validated in seven different countries, and its predictive capacity has also been extended to DCIS progression, human prostate cancers and metastatic melanoma. 8,10,[35][36][37][38][39][40][41] In addition, the expression of stromal MCT4 appears to inversely correlate with stromal Cav-1, allowing them to be used together as companion diagnostics for the detection of "two-compartment tumor metabolism." 31 However, in addition to these stromal diagnostics, new epithelial biomarkers are desperately needed to identify the corresponding onset of mitochondrial biogenesis in human breast cancer cells.…”
Section: Resultsmentioning
confidence: 99%
“…recurrence, metastasis, decreased survival, therapy resistance and overall poor clinical outcome in breast cancer patients. [49][50][51][52]54,[64][65][66][67][68] Follow-up studies have demonstrated that Cav-1 is degraded by autophagy, and that a loss of Cav-1 is a functional reporter of an autophagic and lethal tumor microenvironment. 30,46 Thus, induction of autophagy by PPARγ may be one the mechanism(s) leading to a loss of Cav-1 in fibroblasts.…”
Section: Discussionmentioning
confidence: 99%
“…Cell lines were obtained from the European Collection of Animal Cell Cultures and were cultured as described previously [27,28]. Bimonthly Mycoplasma checks (MycoAlert Mycoplasma detection assay, Lonza [Basal, Switzerland]) were consistently negative and short tandem repeat profiles confirmed cell identity.…”
Section: Methodsmentioning
confidence: 99%