Clinical and Genetic Characteristics of Familial Hypercholesterolemia at Sultan Qaboos University Hospital in Oman

Al-Waili, Khalid; Al-Rasadi, Khalid; Zadjali, Fahad; Al-Hashmi, Khamis; Al-Mukhaini, Suad; Al-Kindi, Mohammed Nasser; Al-Sabti, Hilal; Al-Hinai, Ali T.; Farhan, Hatem; Al‐Zakwani, Ibrahim

doi:10.5001/omj.2020.59

Cited by 7 publications

(7 citation statements)

References 18 publications

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“…The estimated prevalence of familial hyperlipidemia in Oman is around 28,000 patients. 9 This implies that there might be a significant failure to recognize this disease, which is a major contributor of premature coronary artery disease and SCD.…”

Section: Discussionmentioning

confidence: 99%

Sudden Cardiac Death in Patients Under 49 Years Including Adolescents

Maddali,

Al Habsi,

Al Dhamri

et al. 2023

Sultan Qaboos Univ Med J

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Objectives: This study aimed to identify the incidence of sudden cardiac death (SCD0 in adult patients under the age of 49 years, including adolescents with an out-of-hospital cardiac arrest that presented to the emergency department of a tertiary care hospital. Methods: This retrospective cross-sectional study was conducted at the Royal Hospital, Muscat, Oman, between January 2015 and December 2019. All patients with out-of-hospital cardiac arrest were enrolled. The incidence of SCD was evaluated. Information about the patient's demographic data, the site of cardiac arrest, the mode of arrival, the duration of pre-arrest symptoms and if cardiopulmonary resuscitation was performed was gathered. Survival data at 3-year follow-up was obtained. Results: A total of 117 out of 769 (15%) patients met the criteria for SCD. Male gender was predominant, with a median age of 33 years. In about 79.5% of the patients, cardiac arrest was witnessed. Only 43 patients (36.8%) received cardiopulmonary resuscitation at the arrest site; 21 patients (17.9%) had a shockable rhythm and 96 patients (82.1%) had a non-shockable rhythm. Spontaneous circulation was returned in 15 patients (12.8%). Nine patients (7.7%) were discharged from the hospital and 8 (6.8%) survived at least 36 months. Conclusion: The study findings indicate the prevalence of SCD among patients who experienced a cardiac arrest outside the hospital. Unfortunately, only a small number of patients were able to survive in the long term. By implementing preemptive screening for individuals and their families, it may be possible to prevent SCD and improve outcomes for those affected. Keywords: Death, Sudden, Cardiac; Epidemiology; Etiology; Risk Factors; Incidence; Cardiopulmonary Resuscitation; Retrospective Studies; Oman.

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Section: Discussionmentioning

confidence: 99%

Sudden Cardiac Death in Patients Under 49 Years Including Adolescents

Maddali,

Al Habsi,

Al Dhamri

et al. 2023

Sultan Qaboos Univ Med J

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“…There are two such comprehensive centers in the country; the present study constitutes a single-center study. Currently, most suspected FH cases (individuals with a high probability of having FH according to DLCN criteria and those who did not respond to low-intensity statin therapy) are referred to the SQUH lipid clinic for genetic confirmation and advanced management [ 31 ] ( Figure 1 ). Medium-intensity statin therapy to high-intensity statin therapy, Statin + ezitimibe combination, or lipopheresis, are parts of a comprehensive management protocol for patients admitted here with FH [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

“…Currently, most suspected FH cases (individuals with a high probability of having FH according to DLCN criteria and those who did not respond to low-intensity statin therapy) are referred to the SQUH lipid clinic for genetic confirmation and advanced management [ 31 ] ( Figure 1 ). Medium-intensity statin therapy to high-intensity statin therapy, Statin + ezitimibe combination, or lipopheresis, are parts of a comprehensive management protocol for patients admitted here with FH [ 31 ]. Since invasive lipid apheresis has the potential to be strenuous, the measures were all administered prior to treatment in order to avoid the adverse effect of the procedure.…”

Section: Methodsmentioning

confidence: 99%

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A Comprehensive Neuropsychological Study of Familial Hypercholesterolemia and Its Relationship with Psychosocial Functioning: A Biopsychosocial Approach

et al. 2022

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BACKGROUND: Over the past few years, there has been an increasing interest in viewing the diagnosis of familial hypercholesterolemia (FH) through the lens of the biopsychosocial model. However, other than a few epidemiological surveys, there is a dearth of studies from emerging economies that have examined FH using the biological, psychological, and socio-environmental facets of the aforementioned model. AIM. The three aims of the current study were as follows: (i) to examine the psychosocial status among patients with genetically confirmed FH, (ii) to compare their intellectual capacity and cognitive outcomes with a reference group, and (iii) to examine the relationship between health literacy and cognitive functioning. METHOD: Consecutive FH patients referred to the lipid clinic at a tertiary care center for an expert opinion were recruited into this study conducted from September 2019 to March 2020. Information regarding psychosocial functioning, health literacy, quality of life, and affective ranges was surveyed. Indices of current reasoning ability and cognition (attention and concentration, memory, and executive functioning) were compared with a socio-demographically-matched reference group. The current hypothesis also explored the impact of FH on health literacy and cognition. RESULT: A total of 70 participants out of 106 (response rate: 66.0%) initially agreed to participate. However, 18 out of 70 dropped out of the study, yielding a final total of 52 FH patients. With 27 (51.9%) males and 25 (48.1%) females, the mean participant age stood at 37.2 years (SD = 9.2), ranging from 21 to 52 years of age. In the psychosocial data, thirty-two percent (n = 17) of them had anxiety (HADS ≥ 8), and twenty-five percent (n = 13) had depressive symptoms (HADS ≥ 8). The performance of the FH patients was significantly impaired compared to the control group on the indices of current reasoning ability and all domains of cognitive functioning. In the univariate analysis conducted to compare cognitive functioning with health literacy status, only indices of attention and concentration emerged as being significant. CONCLUSION: The current study indicates that the FH population is marked with impediments in biopsychosocial functioning, including indices tapping into the integrity of health literacy, quality of life, affective ranges, and higher functioning such as cognition and current reasoning ability when compared with a socio-demographically-matched reference group. The present results support the hypothesis that chronic diseases vis-à-vis the sequelae of coronary artery disease can potentially impede biopsychosocial functioning.

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“…Depending on the severity of diseases like mild, moderate, severe, and critical, the Infected people are sent to appropriate COVID care centers or at home isolation. The authorities are monitoring their progress daily and taking appropriate actions 22 .…”

Section: Methodsmentioning

confidence: 99%

SEAMHCRD deterministic compartmental model based on clinical stages of infection for COVID-19 pandemic in Sultanate of Oman

Varghese¹,

Kolamban²,

Sherimon³

et al. 2021

Sci Rep

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The present novel coronavirus (COVID-19) infection has engendered a worldwide crisis on an enormous scale within a very short period. The effective solution for this pandemic is to recognize the nature and spread of the disease so that appropriate policies can be framed. Mathematical modelling is always at the forefront to understand and provide an adequate description of the transmission of any disease. In this research work, we have formulated a deterministic compartmental model (SEAMHCRD) including various stages of infection, such as Mild, Moderate, Severe and Critical to study the spreading of COVID-19 and estimated the model parameters by fitting the model with the reported data of ongoing pandemic in Oman. The steady-state, stability and final pandemic size of the model has been proved mathematically. The various transmission as well as transition parameters are estimated during the period from June 4th to July 30th, 2020. Based on the currently estimated parameters, the pandemic size is also predicted for another 100 days. Sensitivity analysis is performed to identify the key model parameters, and the parameter gamma due to contact with the symptomatic moderately infected is found to be more significant in spreading the disease. Accordingly, the corresponding basic reproduction number has also been computed using the Next Generation Matrix (NGM) method. As the value of the basic reproduction number (R0) is 0.9761 during the period from June 4th to July 30th, 2020, the disease-free equilibrium is stable. Isolation and tracing the contact of infected individuals are recommended to control the spread of disease.

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Clinical and Genetic Characteristics of Familial Hypercholesterolemia at Sultan Qaboos University Hospital in Oman

Cited by 7 publications

References 18 publications

Sudden Cardiac Death in Patients Under 49 Years Including Adolescents

Sudden Cardiac Death in Patients Under 49 Years Including Adolescents

A Comprehensive Neuropsychological Study of Familial Hypercholesterolemia and Its Relationship with Psychosocial Functioning: A Biopsychosocial Approach

SEAMHCRD deterministic compartmental model based on clinical stages of infection for COVID-19 pandemic in Sultanate of Oman

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