Clinical and genetic characteristics of hereditary pancreatitis in Europe

Howes, Nathan; Lerch, Markus M.; Greenhalf, William; Stocken, Deborah; Ellis, Ian; Simon, Péter; Truninger, Kaspar; Ammann, R; Cavallini, Giorgio; Charnley, Richard; Uomo, Generoso; Delhaye, Marie; Špičák, Julius; Drumm, Brendan; Jansen, J. B. M. J.; Mountford, Roger; Whitcomb, David C.; Neoptolemos, John P.

doi:10.1016/s1542-3565(04)00013-8

Cited by 547 publications

(381 citation statements)

References 22 publications

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“…[3][4][5][6][7][8] In the present study, 28% of patients with CP developed DM, which is comparable with previous studies. Our study is consistent with previous studies in risk factors such as alcoholism 3,4 and distal pancreatectomy.…”

Section: Discussionsupporting

confidence: 91%

“…17,22 Hereditary CP refers to 2 first-degree relatives or !3 second-degree relatives, in !2 generations with recurrent acute pancreatitis and/or CP, for which there were no precipitating factors. 5 Although it remains a controversy whether abnormal anatomy of pancreatic duct (including pancreas divisum and anomalous pancreaticobiliary junction) is a cause of CP, we defined it as an etiology. 23 Patients were defined as having post-traumatic CP when there was a history of abdominal trauma with imaging evidence of pancreatic injury and subsequent ductal dilation.…”

Section: Definitionsmentioning

confidence: 99%

“…1,2 Decrease in beta cells and insulin resistance contributes to diabetes mellitus (DM), which accounts for 26% to 41% in the natural course of CP. [3][4][5][6][7][8] The micro-or macrovascular damage secondary to DM is a major threat for CP patients, increasing the mortality. 9,10 Referred to as brittle diabetes, DM secondary to CP (type 3c DM) is characterized by frequent episodes of hypoglycemia, which is difficult to control and affects quality of life of patients with CP.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for diabetes mellitus in chronic pancreatitis: A cohort of 2,011 patients

Xin

2016

Pancreatology

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Section: Discussionsupporting

confidence: 91%

Section: Definitionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Risk factors for diabetes mellitus in chronic pancreatitis: A cohort of 2,011 patients

Xin

2016

Pancreatology

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“…[11] Notably, smoking significantly enhanced the risk of malignancy. Similar findings have been reported by the EUROPAC study [12] which concluded that the cumulative risk of pancreatic cancer from symptom onset was 1.5 % at 20 years, going up to 44.0 % at 70 years from symptom onset.…”

Section: The Association Between Chronic Pancreatitis and Pancreatic supporting

confidence: 89%

Pancreatic Cancer in Chronic Pancreatitis

Dhar

Kalghatgi

Saraf

2015

Indian J Surg Oncol

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Data exists to indicate a definite association between chronic pancreatitis and pancreatic cancer. The strength of this association varies between various causes of pancreatitis, with hereditary and tropical pancreatitis more likely to result in malignancy. Pathogenesis may involve genetic factors, diabetes, smoking and alcohol consumption. Clinically a significant overlap exists between the two conditions, with histology difficult to obtain and interpret in this setting. Biomarkers like CA19-9 and others may be useful, as is a variety of newer imaging modalities. Treatment needs to be individualised as surgery offers the only chance of cure, albeit in but a few.

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“…Lowenfels and colleagues' cohort study of 412 hereditary pancreatitis patients in the United States showed that the risk of PC was approximately 50 to 60 times greater than background population (Lowenfels et al, 2000). A cohort study of 418 hereditary pancreatitis cases from 14 European countries revealed that the cumulative risk of PC was 44.0% (95% CI: 8.0%-80.0%) at 70 years from symptom onset, and the standardized incidence ratio reached 67.0% (95% CI: 50.0%-82.0%) (Howes et al, 2004). A recent published study of France cohort documented that the relative risk of PC for the whole population, men, and women were 87.0 (95% CI: 42.0-113.0), 69.0 (95% CI: 25.0-150.0), and 142.0 (95% CI: 38.0-225.0), respectively (Rebours et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Association Between Pancreatitis and Subsequent Risk of Pancreatic Cancer: a Systematic Review of Epidemiological Studies

Tong¹,

Geng²,

Chai³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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This study aimed to summarize published epidemiological evidence for the relationship between pancreatitis and subsequent risk of pancreatic cancer (PC). We searched Medline and Embase for epidemiological studies published by February 5 th , 2014 examining the risk of PC in pancreatitis patients using highly inclusive algorithms. Information about first author, year of publication, country of study, recruitment period, type of pancreatitis, study design, sample size, source of controls and attained age of subjects were extracted by two researchers and Stata 11.0 was used to perform the statistical analyses and examine publication bias. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated with the random effects model. A total of 17 articles documenting 3 cohort and 14 case-control studies containing 14,667 PC cases and 17,587 pancreatitis cases were included in this study. The pooled OR between pancreatitis and PC risk was 7.05 (95%CI: 6.42-7.75). Howeever, the pooled ORs of case-control and cohort studies were 4.62 (95%CI: 4.08-5.22) and 16.3 (95%CI: 14.3-18.6) respectively. The risk of PC was the highest in patients with chronic pancreatitis (pooled OR=10.35; 95%CI: 9.13-11.75), followed by unspecified type of pancreatitis (pooled OR=6.41; 95%CI: 4.93-8.34), both acute and chronic pancreatitis (pooled OR=6.13; 95%CI: 5.00-7.52), and acute pancreatitis (pooled OR=2.12; 95%CI: 1.59-2.83). The pooled OR of PC in pancreatitis cases diagnosed within 1 year was the highest (pooled OR=23.3; 95%CI: 14.0-38.9); and the risk in subjects diagnosed with pancreatitis for no less than 2, 5 and 10 years were 3.03 (95%CI: 2.41-3.81), 2.82 (95%CI: 2.12-3.76) and 2.25 (95%CI: 1.59-3.19) respectively. Pancreatitis, especially chronic pancreatitis, was associated with a significantly increased risk of PC; and the risk decreased with increasing duration since diagnosis of pancreatitis.

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Clinical and genetic characteristics of hereditary pancreatitis in Europe

Cited by 547 publications

References 22 publications

Risk factors for diabetes mellitus in chronic pancreatitis: A cohort of 2,011 patients

Risk factors for diabetes mellitus in chronic pancreatitis: A cohort of 2,011 patients

Pancreatic Cancer in Chronic Pancreatitis

Association Between Pancreatitis and Subsequent Risk of Pancreatic Cancer: a Systematic Review of Epidemiological Studies

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