Clinical and genetic investigation of pediatric cases of Wolff-Parkinson-White syndrome in Tunisian families

Nouira, Saïd; Ouarda, Fatma; Charfeddine, Chérine; Arfa, Imen; Ouragini, Houyem; Abid, F; Abdelhak, Sonia

doi:10.1016/j.hrtlng.2009.10.012

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…The preponderance of patients with the WPWS appear without definable causes, with far fewer affected individuals manifesting a familial variant. The mode of inheritance of WPWS (OMIM 194200) is autosomal dominant, attributed to a heterozygous mutation in the PRKAG2 gene from chromosome 7q36.1 that encodes for the 5′‐AMP‐activated protein kinase subunit gamma‐2 protein controlling cardiac intracellular energy 39,40 . Isolated instances of physical assault 41 or electrical injury 42 have resulted in the sudden onset of WPWS in previously unaffected individuals.…”

Section: Discussionmentioning

confidence: 99%

Wolff–Parkinson–White syndrome: Review of published cases associated with head and neck/oral and maxillofacial procedures

et al. 2022

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Aim The objective of this article is to review the demographics, diagnostic criteria, etiopathogenesis, comorbidities and management of Wolff–Parkinson–White syndrome (WPWS). In addition, the relevant cardiovascular outcomes of published cases involving head and neck/oral and maxillofacial procedures were summarized. Materials and Methods A search of the PubMed database, restricted to human studies published in the English language literature, was performed from 1960 through July 2021 for articles. Results The search strategy yielded 24 patients, totalling 25 dates of treatment, with WPWS concordant with head and neck/oral and maxillofacial procedures, predominately involving biopsy, tumour resection and extractions; significantly, 5 of whom, experienced their first episode of WPWS while undergoing treatment of the head and neck. None of the procedures resulted in patient death. Conclusions Practitioners should be familiar with the clinical features of WPWS and be prepared to manage emergent cardiovascular deterioration. Electrocardiogram monitoring of this cohort is advised during head and neck/oral and maxillofacial surgical procedures, particularly involving general anaesthesia. Breakthrough episodes of WPWS may still occur in patients who have previously undergone cardioconversion.

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Section: Discussionmentioning

confidence: 99%