Clinical and Hematological Changes in Childhood Malaria in India

Chhawchharia, Ritika; Kolhe, Shital; George, Riya; Lahiri, Keya

doi:10.9790/0853-50768690

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…Study done in Ethiopia observed that the thrombocytopenia was found in 56.8%, while mild, moderate, and severe thrombocytopenia accounted for 41.6%, 45.3% and 13.1% (23). Similar studies in endemic area found the severe thrombocytopenia was 8.8% in 45.6% of thrombocytopenia in France, 14.1% in 43.6% of thrombocytopenia in Senegal, 14.8% and in 58% of thrombocytopenia in Libreville (Moulin et al, 2003), 5% in 49% of thrombocytopenia in Kenya (30), 1.5% in 48.6% of thrombocytopenia in Colombia (31), and 12.9% in 68.7% of thrombocytopenia in India (32). Similar previous studies observed that the thrombocytopenia was significantly more frequent and more profound in those with SM than in those with mild forms (31,33).…”

Section: Discussionsupporting

confidence: 56%

“…Thrombocytopenia had strong negative correlation with parasitemia (r -0.335, P value 0.000), and parasite count (r -0.268, P value 0.000). Previous studies concluded that the thrombocytopenia is associated with peripheral parasitemia levels (14,30,32,(34)(35)(36). The average of platelets count among Group 2 was lower than Group 2 (P value 0.000).…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic and prognostic value of thrombocytopenia severity in Sudanese children with Falciparum malaria

Mohamedahmed¹,

Nour²,

Abakar³

et al. 2020

World J. Adv. Res. Rev.

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Malaria remains one of the most significant global public health challenges, with more than 200 million clinical cases worldwide each year. Falciparum malaria accounting for up to 87.6 % of malaria cases in Sudan. Platelets abnormalities as thrombocytopenia especially severe thrombocytopenia have been associated with mortality in patients with P. falciparum infection. The aim of this study was to study the relationships between thrombocytopenia and their severity with falciparum malaria severity, parasitemia and parasite count. This study was case-control hospital based study conducted among 200 Sudanese children admitted to Wad Medani Pediatric Hospital, Wad Medani, Sudan during period September to December 2018. The study population was divided into two groups. Group 1 (UM) was 100 children with uncomplicated falciparum malaria. Group 2 (SM) was 100 children with severe falciparum malaria were diagnosed by WHO criteria. A 2.5 ml venous blood sample was collected from each children. The malaria parasitemia was determined from thick blood films using plus system. The parasite count (% of parasitized red cells counting) was counted from thin blood film. Platelets count was determined using the Sysmex XP 300 N automated hematology analyzer (Sysmex, Kobe, Japan) and confirmed and assessed using stained thin blood film. The data were analyzed using SPSS software (V 20.0) and Stat disk software (V 13.0). The mean age and male:

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic value of thrombocytopenia severity in Sudanese children with Falciparum malaria

Mohamedahmed¹,

Nour²,

Abakar³

et al. 2020

World J. Adv. Res. Rev.

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“…Changes in the hematological examination of patients with malaria can be influenced by several factors, including the level of regional endemicity, the background of hemoglobinopathies, demographic factors and immunity to malaria, but this is not yet known with certainty due to the complex pathogenesis process [13].…”

Section: Introductionmentioning

confidence: 99%

Malaria Cases Rate by Gender in the North Buton Regency During the 2018-2020 Period

Sumriati

Tosepu

Effendy

2022

KLS

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Malaria is a life-threatening disease and causes many deaths around the world. The disease is caused by a protozoan parasite of the genus Plasmodium which is transmitted to humans through the bite of the Anopheles mosquito which also serves as a host for this parasite. The objective of the study is to describe Malaria cases in the North Buton Regency in the 2018-2020 period based on gender. This is a survey research using data from the health report of the Health Office of North Buton Regency for the period 2018-2020 involving data on the malaria cases by gender. The research sample is malaria sufferers. The type of research data is numerical and the research data is presented in the form of a graph with narration. Malaria cases by gender in the North Buton regency showed that in 2018 the highest was at the Kulisusu Health Center with 12 cases, in 2019 the highest was at the Bonerombo Health Center with 7 cases, and then in 2020 the highest was at the Lambale Health Center with 6 cases. The number of cases in North Buton Regency was more dominated by men than women. Keywords: Malaria, Gender, Male, Female, Plasmodium

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Impact of Sever Plasmodium falciparum infection on Platelets Parameters among Sudanese children Living in Al-Jazira State

Mohamedahmed¹,

Ahmed²,

Nour³

et al. 2020

IJCBR

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Background: Falciparum malaria remains one of the most global infection among children particularly in communities with poor resources. Falciparum malaria associated with several hematological changes that affect the major blood cell lines such as platelets lead to platelets parameters (platelets count and indices) abnormalities. Objectives: The aim of this study was to evaluate the effects of falciparum malaria on platelets parameters (platelets count and indices) among Sudanese children. In addition to study relationships and correlation between platelets parameters and malaria parasitemia and parasite count. Materials and Methods: A case control study was conducted in Wad Medani Pediatric Hospital in collaboration with Faculty of Medical laboratory Sciences, University of Gezira, Sudan among 100 children with severe falciparum malaria (mean age 8.63 ± 3.40 years; 61% males), 100 children with uncomplicated falciparum malaria (mean age 8.83 ± 4.20 years; 45% males) and 100 children with normal healthy children controls (mean age 10.08 ± 3.58 years; 50% males). Parasitemia and parasite count (%) was determined directly from thick and thin blood films respectively. The platelets parameters (platelets count and indices) measured by using Sysmex XP 300 N automated analyzer, and platelets count was confirmed and assessed using stained thin blood film. SPSS software (V 20.0) and Stat disk software (V 13.0) were used for data analysis. Results: 72 % of severe falciparum malaria (SM) have hyperparasitemia, while 18 % among uncomplicated falciparum malaria (UM). The thrombocytopenia account for 43 % (SM: 30.5 %; UM: 12.5 %), low PCT account for 35.5 % (SM: 27 %; UM: 8.5 %) and high PDW account for 46.5 % (SM: 23.5 %; UM: 23 %) in falciparum malaria cases. The mean PLTs count and PDW were statistically significantly differences between falciparum malaria cases and normal healthy control (P value 0.000 and 0.008 respectively). The mean PLTs count and PCT in severe falciparum malaria cases were lower than uncomplicated falciparum malaria cases (P value 0.005 and 0.000 respectively). The PLTs count and PCT had significant negative correlation within malaria parasitemia (P value 0.000; r -0.286; P value 0.004; r -0.205 respectively) and malaria parasite count (P value 0.000; r -0.450; P value 0.000; r -0.270 respectively). Conclusion: The study concluded that thrombocytopenia, low PCT and high PDW were observed as most platelets parameters changes in falciparum malaria. PLTs count along with PCT to be recommended as hematological diagnostic markers and prognostic tool to assess the disease severity and to improve the management of falciparum malaria among patients.

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Clinical and Hematological Changes in Childhood Malaria in India

Cited by 3 publications

References 23 publications

Diagnostic and prognostic value of thrombocytopenia severity in Sudanese children with Falciparum malaria

Diagnostic and prognostic value of thrombocytopenia severity in Sudanese children with Falciparum malaria

Malaria Cases Rate by Gender in the North Buton Regency During the 2018-2020 Period

Impact of Sever Plasmodium falciparum infection on Platelets Parameters among Sudanese children Living in Al-Jazira State

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