Clinical and histologic healing of lichenoid oral lesions following amalgam removal: a prospective study

The role of patch testing in the management of oral lichenoid reactions

“…A close look at the publications since the year 2000 suggests that in half of the studies, over 50% of subjects with suspected OLR had reacted positive to patch testing. The overall patch test positivity varied between 24% and 70% when typical OLR were investigated and the frequencies were reported to be lower when OLP was included. Our data confirming patch test positivity in 67.8% to any restorative material and 52.2% positive to an amalgam‐related allergen compares well with published reports.…”

“…Previous studies have examined the relationship between the dental restorations and the topographical association of OLR . Five of these studies concluded that the topographical relationship may be a more useful predictive factor than patch testing.…”

Mucosal Lesions in an Allergy Practice

“…Disease improvement occurred most frequently in lesions located adjacent to the dental amalgam [22]. Another study showed around half of OLP patients that experienced clinical improvement after dental amalgam removal had corresponding resolution of OLP histologic findings [20].…”

“…There is a body of research on the clinical results of OLP patients following dental amalgam removal and its association with patch testing [14,17,[20][21][22][23][24][25]. A systematic review of 14 cohort and five case-controlled trials of patients with OLP demonstrated that after dental amalgam replacement, between 35 and 100 % of patients had complete disease resolution.…”

Oral Lichen Planus: Diagnosis and Management

“…The predictive value of epicutaneous patch testing for amalgam and mercury allergy is rather questionable. 15,16 In contrast todrug-induced cutaneous lichenoid lesions drug-induced oral lichenoid lesions are extremely rare. Nevertheless, one may consider to adjust the medication (Box 1), if applicable.…”