Clinical and Histological Characteristics of Nasopharyngeal Cancer in Sokoto, North Western, Nigeria

Iseh, KR; Abdullahi, A; Malami, SA

doi:10.4314/wajm.v28i3.48438

Cited by 6 publications

(11 citation statements)

References 14 publications

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“…This falls within the range of results obtained in Ghana [17, 28] and elsewhere [7, 21, 28–30] where the number of men was twice as or higher than that of women. The younger Ghanaian subjects (≤40 years), who accounted for 56.9% of our study subjects, were more likely to have EBV positive NPC tumours (OR = 0.58), as compared to patients older than 40 years (>40 years).…”

Section: Discussionsupporting

confidence: 89%

Detection of Human Papillomavirus Genotypes and Epstein-Barr Virus in Nasopharyngeal Carcinomas at the Korle-Bu Teaching Hospital, Ghana

Asante

Asmah

Adjei

et al. 2017

The Scientific World Journal

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Nasopharyngeal carcinomas (NPC) are endemic in Far East Asia and commonly harbour Epstein-Barr virus (EBV) which is known to serve as a key oncogenic promoter. Human papillomavirus (HPV) is known to contribute to the pathogenesis of NPC. However, in Ghana these two viruses have not been linked to NPC prevalence. This study was designed to determine the HPV genotypes and EBV involved in NPC tissue biopsies. A retrospective study design involving 72 formalin-fixed paraffin-embedded tissue (FFPET) samples of NPC from 2006 to 2012 were retrieved from the Department of Pathology, University of Ghana School of Biomedical and Allied Health Sciences. Sections were taken for histological analysis and for DNA lysate preparation. The DNA lysates were subjected to polymerase chain reaction (PCR) analysis to determine the presence of HPV genotypes and EBV. HPV specific primers were used to type for fourteen HPV genotypes (HPV-16, 18, 6/11, 31, 33, 35, 44, 42, 43, 45, 56, 52, 58, and 59). Out of the 72 NPC biopsies analyzed by PCR, EBV DNA was present in 18 (25%) cases and HPV DNA in 14 (19.23%). High risk HPV (HR-HPV) genotypes 18 and 31 were associated with the NPC. There were 3 (4.2%) cases of coinfection by both viruses. The EBV DNA present in the undifferentiated variant of the NPC and the histopathology of the NPC in Ghana is similar to the type described in endemic areas.

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Section: Discussionsupporting

confidence: 89%

Detection of Human Papillomavirus Genotypes and Epstein-Barr Virus in Nasopharyngeal Carcinomas at the Korle-Bu Teaching Hospital, Ghana

Asante

Asmah

Adjei

et al. 2017

The Scientific World Journal

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“…This pattern of age group distribution is typically observed in non-endemic population in contrast to endemic population where there are two age group peaks, usually a minor peak in the young and a more prominent peak in much older age groups, usually in the 6 th decade of life [ 2 , 6 , 15 ]. Typically, NPC presents in the early phase of the disease with nonspecific symptoms leading to delay in patients´ seeking medical attention and where there is visit to the hospital, the symptoms are treated as benign condition as reported from different studies from all parts of the world [ 6 , 8 , 11 - 13 , 20 , 23 , 25 , 27 - 29 ]. The delay in diagnosis therefore makes the attempt at curative therapy very difficult.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study

Ogun¹,

Olusanya²,

Akinmoladun³

et al. 2020

PAMJ

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Introduction nasopharyngeal carcinoma is relatively common in our environment. It is one of the most difficult malignancies to diagnose at an early stage. The aim of the study was to determine the clinical features, clinical disease stage of nasopharyngeal carcinoma at presentation and at diagnosis as well as the histologic types at the University College Hospital, Ibadan, Nigeria. Methods this was a ten year retrospective study of all histologically confirmed nasopharyngeal carcinoma between January 2007 to December 2016 using clinical and pathology records and files. Results there were 73 cases. The male: female ratio was 1.7. The age of patients ranged from 12 to 80 years with a mean age of 39 ± 16 years. The median age at diagnosis was 40 years. The peak age group of occurrence was 40-49 years. The most common symptoms were namely epistaxis in 67.1% of patients at presentation, neck mass/swelling (64.4%) and nasal mass/obstruction (63.0%). Majority (54.8%) of the patients presented late with stage 3 or 4 disease. Most (94.5%) of the tumours were of the non-keratinizing squamous cell carcinoma subtype. The keratinizing and basaloid variants accounted for 4.1% and 1.4% of the tumours respectively. Conclusion vague, non-specific symptoms make patients present at late stages of the disease, making it almost impossible to attempt cure. The dominant histopathological type is non-keratinizing squamous cell carcinoma and resembles that seen in most parts of Nigeria and endemic areas of the world.

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“…The hidden nature of the nasopharyngeal space poses diagnostic and therapeutic challenges, thus allowing significant spread of the disease before diagnosis [8]. The inclusion of nasopharyngoscopy in the clinical setting has greatly increased early diagnosis of nasopharyngeal cancer with consequently improved prognosis of the disease [9].…”

Section: Discussionmentioning

confidence: 99%

“…of 30 patients in north-western Nigeria reported clinical presentations of deafness and otalgia in 36.3% and 30% of patients, respectively. Other clinical presentations included cervical lymphadenopathy (93.3%), epistaxis (83.3%), nasal obstruction (66.7%), palatal swelling (26.7%), cranial nerve involvement (23.3%) and visual impairment (20%) [8]. A study by Sham et al .…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal cancer mimicking otitic barotrauma in a resource-challenged center: a case report

Daniel

Fasunla

2011

J Med Case Reports

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IntroductionNasopharyngeal cancer commonly manifests with cervical lymphadenopathy, recurrent epistaxis and progressive nasal obstruction. Neuro-ophthalmic and otologic manifestations can also occur. Isolated otologic presentations of nasopharyngeal cancer are rare and the diagnosis of nasopharyngeal cancer may not be foremost in the list of differentials.Case presentationWe present the case of a 29-year-old Nigerian woman with bilateral conductive hearing loss and tinnitus after air travel. There were no other symptoms. The persistence of the symptoms after adequate treatment for otitic barotrauma necessitated re-evaluation, which led to a diagnosis of nasopharyngeal cancer.ConclusionIsolated otologic manifestations of nasopharyngeal cancer are rare in regions with low incidence of the disease. There is a need for it to be considered as a possible differential in patients presenting with bilateral serous otitis media.

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Clinical and Histological Characteristics of Nasopharyngeal Cancer in Sokoto, North Western, Nigeria

Cited by 6 publications

References 14 publications

Detection of Human Papillomavirus Genotypes and Epstein-Barr Virus in Nasopharyngeal Carcinomas at the Korle-Bu Teaching Hospital, Ghana

Detection of Human Papillomavirus Genotypes and Epstein-Barr Virus in Nasopharyngeal Carcinomas at the Korle-Bu Teaching Hospital, Ghana

Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study

Nasopharyngeal cancer mimicking otitic barotrauma in a resource-challenged center: a case report

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