Clinical and histological comparison of platelet-rich fibrin versus non-eugenol periodontal dressing in the treatment of gingival hyperpigmentation

Abstract

Background: The platelet-rich fibrin (PRF) has proven an immense role in angiogenesis and epithelization in a wound healing process. The present study aims to ascertain PRF's beneficial role in wound healing after depigmentation surgery. Materials and Methods: A total of 12 systemically healthy controls included were divided into two groups after scalpel depigmentation procedure. PRF was prepared according to Choukroun's standard protocol. Using split-mouth design after depigmentation, one group received PRF membrane, and in second group non-eugenol periodontal dressing was placed. The participants were evaluated for visual analog scale (VAS), healing index (HI) on 3 rd and 5 th day. Epithelization test using toluidine blue and histological examination employing punch biopsy was done on the 5 th day. Results: On statistical scale, VAS, HI, epithelization test, and histological findings were statistically significant in the two study groups. PRF group proved better epithelization test and inflammatory cell infiltration was less in PRF group which confirmed superior wound healing in the group. Conclusion: PRF membrane postdepigmentation provided satisfactory patient comfort and enhanced the wound healing cascade.

Injectable platelet rich fibrin effect on laser depigmented gingiva: a clinical randomized controlled split mouth trial with histological assessment

“…These results are comparable to those documented by Debnath and Chatterjee 16 (2018) who compared PRF membrane to periodontal dressing on the third and fifth days following abrasion depigmentation technique. Our outcomes are also comparable with Dahiya, et al 15 (2019) and Bansal, et al 17 (2016) who used scalpel technique.…”

“…However, these results differ from other studies that applied PRF membranes following surgical depigmentation techniques, as they documented that pain scores were lower with the use of platelet concentrates. 15 - 17 Early epithelization and anti-inflammatory effect of i-PRF probably caused covering and less stimulation of peripheral nerve endings in laser-exposed connective tissue.…”

“…Different methods have been investigated to accelerate wound healing and improve patient satisfaction following gingival depigmentation procedure, including low-level laser treatments, 13 ozonated oil, 14 and bioactive materials, such as platelet concentrates. 15 - 17 …”

“…Several studies have demonstrated that PRF in membrane form was a successful approach to protect the raw wound area and reduce healing time and patient discomfort when sutured over the gingival depigmented site. 15 , 16 Moreover, other studies have documented the influence of i-PRF on increasing gingival thickness. 20 , 21 …”

Despigmentación gingival mediante mucoabrasion en el sector anterior. Reporte de caso

“…Nuestra experiencia con los casos tratados confirma la practicidad y la simplicidad de la mucoabrasión, además de obtener resultados favorables en corto tiempo. La técnica también puede ser combinada con Plasma Rico en Fibrina (PRF) para acelerar el proceso de cicatrización [11][12][13] . Se considera que remover estas manchas permite mejorar la apariencia y la sonrisa del paciente; una sonrisa estética no solo crea un impacto en los espectadores, sino que también mejora la personalidad y la autoconfianza del individuo 14 .…”