Nail disorders are prevalent dermatologic complaints and present at any age. 50% of the nail disorders were due to infectious causes, 15% were due to metabolic or inflammatory causes, and 5% were due to pigment disturbances and malignancies. The differential diagnosis of nail disorders is still often a field of incertitude. 1 Clinical evaluation is still an issue in such cases. The nail unit is a greatly specialized structure and there are significant histopathological variations within its components. SO, the mycological assessments, and histopathological examinations are pivotal for the diagnosis of different nail disorders. 1 Two factors can hinder a precise diagnosis of nail disorders. The first factor is that several nail disorders may clinically mimic one another, leading to difficulty in diagnosis. From a practical view, one may consider infectious, inflammatory, and neoplastic processes in the differential diagnosis of a single lesion. So, a biopsy is usually resolve the cell layer that is abnormally found in the nail bed or nail matrix, and it is normally found in the nail fold or hyponychium. 2 The nail biopsy is an essential technique to obtain an accurate diagnosis of clinically ambiguous nail diseases that is not diagnosable by history, clinical examination, and mycology testing , 3 but it is disagreeable with the patient and may lead to scarring and disfigurement of the nail. 4