Clinical and Histopathologic Independent Prognostic Factors in Oral Squamous Cell Carcinoma: A Retrospective Study of 334 Cases

Arduino, Paolo Giacomo; Carrozzo, M; Chiecchio, Andrea; Broccoletti, Roberto; Tirone, Federico; Borra, Eleonora; Bertolusso, Giorgio; Gandolfo, S

doi:10.1016/j.joms.2007.12.024

Cited by 129 publications

(114 citation statements)

References 37 publications

(62 reference statements)

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“…Most of our patients with OSCC (77%; range: 70-91.3%) were also alcohol drinkers, in agreement with previous findings in Hungary (75.5%) (37), Brazil (80.9%) and the USA (69.8%) (35), but in contrast to some studies that found a lower prevalence of alcohol consumption (1,9,34,38,39).…”

Section: Discussionsupporting

confidence: 92%

“…In this study, tobacco exposure was observed in 90% of the patients with OSCC, ranging from 77.8 to 100% intergroup. The profile of our patient regarding tobacco consumption was similar to those detected in some previous studies even in developed countries (9,35,36), but other authors reported a different prevalence (50-65.5%) of smoking patients (1,34,37). The percent of smokers in OL NM was similar to the control group of a study with young adults performed by Rodriguez et al (38).…”

Section: Discussionsupporting

confidence: 88%

“…Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer and occupies the eighth position in cancer incidence worldwide, with an estimated annual incidence of more than 170,000 new cases (1)(2)(3). Only in Brazil, the estimate is for 14,160 new cases in 2009 (4).…”

Section: Introductionmentioning

confidence: 99%

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BUBR1 expression in benign oral lesions and squamous cell carcinomas: Correlation with human papillomavirus

Soares¹

2010

Oncol Rep

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Abstract. Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Only in Brazil, the estimate is for 14,160 new cases in 2009. HPV is associated with increasing risk of oral cancer, but its role in carcinogenesis is still controversial. BUBR1, an important protein in the mitotic spindle assembly checkpoint (SAC), has been associated with some virus-encoded proteins and cancer. The aim of the present study was to evaluate the expression of BUBR1 in non-malignant oral lesions and OSCC with and without metastasis associated with HPV infection. We performed immunohistochemistry for BUBR1 in 70 OSCC biopsies divided into three groups (in situ tumors, invasive tumors without metastasis and invasive tumors with metastasis) with their respective lymph nodes from samples with metastasis and in 16 non-malignant oral lesions. PCR was performed in order to detect HPV DNA. Significantly higher BUBR1 expression associated with shorter survival (p=0.0479) was observed in malignant lesions. There was also a significant correlation (r=1.000) with BUBR1 expression in lesions with metastasis and their lymph nodes. Ninety percent of OSCC and 100% of benign lesions were HPV positive. HPV16 and HVP18 were present in 13 and 24% of HPV-positive OSCC samples, respectively. HPV was more prevalent (76%) in samples with a high BUBR1 expression and the absence of viral DNA had no influence on BUBR1 expression. These findings suggest that HPV could be associated with overexpression of BUBR1 in OSCC, but not in benign oral lesions.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 88%

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BUBR1 expression in benign oral lesions and squamous cell carcinomas: Correlation with human papillomavirus

Soares¹

2010

Oncol Rep

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“…Arduino et al reported that histological grading was related, as an independent factor, in predicting survival in patients with oral squamous cell carcinoma [16] . Shim et al demonstrated thatfactors that significantly affected prognosis after primary surgery were poor tumour differentiation and deep invasion depths over 0.5 cm.…”

Section: Discussionmentioning

confidence: 99%

A Single Institutional Retrospective Study to Analyze the Clinical Outcomes in Patients of Squamous Cell Carcinioma of the Oral Tongue who Underwent Surgery with or without Post-Operative Radiotherapy

Basu¹

2017

jmscr

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“…Apparently, the disparity in the reduction of alcohol and tobacco abuse among men and women seems to explain the increased incidence and mortality observed among female in some studies 3 , leading to a gradual reduction in the men:women ratio 1,4 . Although not included among the most incident malignancies of women in Brazil, about 28% of the new oral cavity cancers affect females in this country 5 . Although current literature still lacks a consensus, there is a trend towards a better prognosis among women with oral cavity cancer [1][2][3][4]6 .…”

mentioning

confidence: 99%

Histopathological Differences Between Genders in Patients With Oral Squamous Cell Carcinoma

Girardi¹,

Fuga²,

Callai³

et al. 2017

Clin. Biomed. Res.

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Clinical and Histopathologic Independent Prognostic Factors in Oral Squamous Cell Carcinoma: A Retrospective Study of 334 Cases

Cited by 129 publications

References 37 publications

BUBR1 expression in benign oral lesions and squamous cell carcinomas: Correlation with human papillomavirus

BUBR1 expression in benign oral lesions and squamous cell carcinomas: Correlation with human papillomavirus

A Single Institutional Retrospective Study to Analyze the Clinical Outcomes in Patients of Squamous Cell Carcinioma of the Oral Tongue who Underwent Surgery with or without Post-Operative Radiotherapy

Histopathological Differences Between Genders in Patients With Oral Squamous Cell Carcinoma

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