Clinical and Histopathologic Review of 18 Explanted Porous Polyethylene Orbital Implants

Use of a gel biopolymer for the treatment of eviscerated eyes: experimental model in rabbits

“…It is noteworthy that even in the last animals sacrificed on day 240, the center of the implant had not been occupied by the cellular response, neovessels, or collagen fibers. The pathological phenomena described above support the integration of the implant into the host and were similar to the phenomena observed in previous studies, including those reviewed by Sami, involving other materials and implants (4,7,27) . When using an integrated polyethylene implant, Ferraz and colleagues observed the formation of a pseudo capsule around this substance and neovessels, together with fibrovascular tissue filling the spaces between the grains of material (26) .…”

“…On clinical examination ( Figure 1C), the absence of intense edema, conjunctival hyperemia, papillary or follicular proliferation, secretions (mucopurulent and bloodymucus), perforation, or early corneal opacification in the eyes that received the polymer suggests that there was no clinically acute disease with the participation of bacteria of high virulence, as occurs in extrusion of solid implants (27) . There were also no signs of acute process, allergic or toxic, which would have suggested a lack of biocompatibility.…”

“…Histiocytic, fibroblastic and neovessels proliferation occurred along with the formation of multinucleated cells of the foreign body type. Finally, the deposition of collagen fibers indicates repair and integration of the implant into the host (25)(26)(27) . In this study, an experimental model using rabbits is proposed to evaluate histologically the integration process of an artificial implant of cellulose gel, produced by Zoogloea sp, used to restore eviscerated eyes.…”

Modern principles of prevention of anophthalmic syndrome: formation of the locomotor stump, the types of orbital implants

“…Благодаря наличию высокой пористости (85% пор имеют диаметр свыше 150 мкм), полимер достаточно легко прорастает фиброваскуляр-ной тканью [24,48]. Однако в ходе исследований установлено, что прорастание пористого поли-ýтилена соединительной тканью при импланта-ции в орбитальную полость составляет не более 60% за 24-48 нед [17].…”

Anophthalmic socket: choice of orbital implants for reconstruction

“…Ultimately, it is impossible to state whether extrusion or the need to remove implants will not occur when using integrated implants. Exposure may favor the colonization of porous implants by bacteria and by dense inflammatory infiltration, thereby necessitating implant removal when spontaneous extrusion does not occur (23) . Previous studies provide no evidence that integrated implants are superior to non-integrated implants (2,24,25) .…”