Clinical and histopathologic studies of the nose and sinuses in allergy

Hansel, French K.

doi:10.1016/s0021-8707(29)90083-6

Cited by 116 publications

(27 citation statements)

References 21 publications

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“…The prevalence of asthma in patients with CRS has been reported to be as high as 50% [6]. Hansel [7 ]called attention to the histopathological similarity between nasal, sinus and bronchial tissues in subjects with asthma, with the most outstanding feature being their infiltration by eosinophils. In all these tissues, the pathological findings, local eosinophilia and thickening of the mucosa and epithelial basement membrane and hyperplasia of goblet cells and gland cells can be seen.…”

Section: Introductionmentioning

confidence: 99%

The Expression of Protease-Activated Receptors in Chronic Rhinosinusitis

Yoshida¹,

Matsuwaki²,

Asaka³

et al. 2013

Int Arch Allergy Immunol

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Background: A recent study suggested that protease-activated receptors (PARs) are involved in allergic respiratory diseases, such as asthma. Chronic rhinosinusitis (CRS) is one of the most common chronic airway diseases, but little is understood about its pathogenesis. The purpose of this study was to compare the expression and distribution of PARs in biopsy specimens obtained from CRS and control patients. Methods: Biopsy specimens were obtained from 7 pituitary tumor patients as controls, 8 CRS patients with aspirin-tolerant asthma (ATA), 7 CRS patients with aspirin-induced asthma (AIA), and 7 CRS patients without asthma (CRS). Sections were stained for PAR-1, PAR-2, PAR-3 and PAR-4 using specific polyclonal antibodies. Staining was scored semiquantitatively for both intensity and distribution. To confirm the presence of PARs on inflammatory cells, double staining with eosinophil cationic protein (EG2) and elastase was also performed. Results: Both the epithelium and the infiltrating inflammatory cells in the CRS with asthma groups showed significant upregulation of the expression of PAR-2 and PAR-3 compared with the CRS without asthma group and the control group. In the patients with CRS complicated by asthma, eosinophils were increased among PAR-2- and PAR-3-positive cells.In the patients with CRS not complicated by asthma, neutrophils were increased among PAR-2-positive cells. Conclusions: Differences in the expression of PAR-2 and PAR-3 on epithelial cells, eosinophils and neutrophils may be involved in the pathogenesis of CRS. CRS may be able to be treated by targeting PAR-2 and PAR-3.

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Section: Introductionmentioning

confidence: 99%

The Expression of Protease-Activated Receptors in Chronic Rhinosinusitis

Yoshida¹,

Matsuwaki²,

Asaka³

et al. 2013

Int Arch Allergy Immunol

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“…The prevalence of asthma in patients with CRS has been reported to be as high as 50% [7]. Hansel [8] called attention to the histopathological similarity between nasal, sinus and bronchial tissues in subjects with asthma. Interestingly, he found the most outstanding feature of these tissues to be their infiltration by eosinophils [8].…”

Section: Introductionmentioning

confidence: 99%

“…Hansel [8] called attention to the histopathological similarity between nasal, sinus and bronchial tissues in subjects with asthma. Interestingly, he found the most outstanding feature of these tissues to be their infiltration by eosinophils [8]. However, we still know little about the factors causing chronic immune activation and persistent eosinophilic inflammation in CRS.…”

Section: Introductionmentioning

confidence: 99%

Chronic Rhinosinusitis: Risk Factors for the Recurrence of Chronic Rhinosinusitis Based on 5-Year Follow-Up after Endoscopic Sinus Surgery

Matsuwaki

Ookushi

Asaka

et al. 2008

Int Arch Allergy Immunol

177

164

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Background: Chronic rhinosinusitis (CRS) is one of the most frequent chronic diseases in the US, and little is understood about its pathogenesis. This study was conducted to characterize, retrospectively, the clinical, objective and immunological parameters that accompany recurrence of CRS during long-term follow-up after surgery. Methods: Fifty-six patients with CRS who had undergone endoscopic sinus surgery were followed up for 5 years after the surgery. The CRS parameters chosen were as follows: history of asthma and/or allergic rhinitis, peripheral eosinophilia of at least 520 cells/µl, peripheral eosinophil count, total IgE, presence of polyps, CT score, presence of fungi (positive fungal culture or stain), mucus or mucosal eosinophilia, mucosal eosinophil count, presence of acute infection after surgery, gender and age. Individual correlations and stepwise regression were performed. Results: Patients with a total peripheral eosinophil count of 520/µl or more and those with asthma were likely to experience recurrence of CRS within 5 years after surgery. Furthermore, patients with mucus or mucosal eosinophilia who were diagnosed as having eosinophilic CRS (ECRS) showed a high incidence of recurrence within 5 years. The parameter of mucus or mucosal eosinophilia (diagnosis of ECRS) had a positive predictive value of 85.7%. Conclusions: Surgeons should always examine the inflammatory infiltrate of nasal polyps or the paranasal mucosa, and patients with ECRS require anti-inflammatory medications, such as steroids, for a long time after surgery. Long-term follow-up is also essential.

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“…1 It was defined in 1929. 2 The three cardinal symptoms in nasal reactions occurring in allergy are sneezing, nasal obstruction and mucous discharge.…”

Section: Introductionmentioning

confidence: 99%

Isotonic nasal spray versus fluticasone nasal spray in treatment of allergic rhinitis

Gaddipatti¹,

Rao²,

Rajiv³

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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Background: Allergic rhinitis (AR) is a prevalent disease with great morbidity and causing signiﬁcant societal and economic burden. Aims and objectives: To compare efficacy of fluticasone nasal spray and isotonic saline nasal spray in allergic rhinitis.Methods: This was a prospective randomized study conducted on patients of allergic rhinitis coming to ENT OPD a tertiary care teaching hospital. Sixty patients diagnosed with concomitant diagnosis of allergic rhinitis was randomly allocated to either Fluticasone propionate nasal spray (n= 30) and isotonic saline spray (n= 30). Results: The most common age group in fluticasone group was 21 to 30 years while in isotonic saline group 31 to 40 years was the most common age group. There was 52.8% of female and 47.2% in fluticasone group while in isotonic saline group, 52.5% of study population were female and 47.5% were male. There was significant improvement in VAS on day 15 and day 30 as compared to day 1 in fluticasone treated subjects as compared to isotonic saline group. After one month, Nasal blockage, nasal discharge, sneezing, nasal itching was improved to 71%, 69%, 81% and 78% in fluticasone treated subjects as compared to isotonic saline group in which improvement was up to 11%, 17%, 09% and 12% respectively and this difference was statistically significant. Conclusions: Fluticasone nasal spray has the potential to enhance patient satisfaction and compliance and reduce the need for polypharmacy in the management of seasonal allergic rhinitis.

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Clinical and histopathologic studies of the nose and sinuses in allergy

Cited by 116 publications

References 21 publications

The Expression of Protease-Activated Receptors in Chronic Rhinosinusitis

The Expression of Protease-Activated Receptors in Chronic Rhinosinusitis

Chronic Rhinosinusitis: Risk Factors for the Recurrence of Chronic Rhinosinusitis Based on 5-Year Follow-Up after Endoscopic Sinus Surgery

Isotonic nasal spray versus fluticasone nasal spray in treatment of allergic rhinitis

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