Clinical and histopathological analysis of oral Squamous cell carcinoma of young patients in Mashhad, Iran: A retrospective study and review of literature

Abstract

Objectives: Oral Squamous cell carcinoma (OSCC) is primarily a disease that mainly occurs in males in their sixth and seventh decades of life and is rare in young adults. Study Design: In this retrospective study, records of patients under the age of 40, with the diagnosis of OSCC in the Oral Medicine Department of Mashhad Dental Faculty during the past 13 years were analyzed. Their socioeconomic data, demographic, clinical and histopathological characteristics, risk factors, familial history were assessed and applicable studies and case reports in the literatures were reviewed. PCR (Polymerase chain reaction) analysis was also done for detection of human papilloma virus (HPV). Results: From 158 cases of OSCC diagnosed in our centre, 21 patients were younger than 40 years. Most of them were young men (12 cases). There was no significant risk factor in this group. The most common site of involvement was the tongue. The most common clinical presentation was exophytic lesion with ulcer. No HPV DNA was detected in these patients. Conclusion: Characteristics of OSCC in young patients are different from older age group. Major risk factors (smoking and alcohol consumption and HPV) were not etiologic factors for OSCC in young patients in our province.

Clinical findings and risk factors associated with oral cancer: a prospective study

“…In our study, of sixty patients, patients presenting with stage IV A disease was slightly more as compared to stage III disease. 11,13,14 There were 22 patients (30%) having stage III carcinoma. Majority of the subjects i.e.…”

“…6 There has been differences in the etiological factors that are responsible for causing oral squamous cell carcinoma amongst young and elderly individuals as the young individuals are exposed to the risk factors like sunlight and tobacco for a short period of time. 9,[11][12][13][14][15] Oral squamous cell carcinoma occurring amongst the younger individuals have an increased aggressiveness and poor clinical prognosis when compared to those affecting the elderly subjects. 6,7,12,16,17 The prognosis of the condition is determined by the prognostic factors that would in turn determine the biological aggressiveness of the condition amongst the subjects.…”

Comparison of COX2 Expression between Oral Squamous Cell Carcinoma, Leukoplakia and Normal Mucosa

“…Recent studies show an increase in early onset oral SCC among young patients in Iran. [1][2][3][4] Iran is a large country located in the Middle East and Khorasan (including North, Razavi and South Khorasan) is the largest province in Iran covering 7.8% of the total area of this country with a population about 7 millions. Oral SCC is among the 10 most common cancers in our province.…”

Découverte d’un carcinome épidermoïde du trigone rétromolaire chez un jeune adulte sans facteurs de risque

“…L'étiologie diffère également, les facteurs extrinsèques classiques tels que le tabac et l'alcool ne sont pas toujours retrouvés [3,9]. Le seuil d'intoxication (environ 21 années de tabagisme) n'est jamais atteint chez le jeune car l'exposition est trop courte.…”