Clinical and histopathological study of actinic keratosis treatment with photodynamic therapy VS 5-fluorouracil for face cancerization

Romero, María Paulina; Posso, Verónica; Ureña, Valeria; Inada, Natália Mayumi; Bagnato, Vanderlei Salvador; Cabrera, Franklin

doi:10.1016/j.pdpdt.2022.102967

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…AK, which are precancers with the potential to progress to invasive SCC, are treated by dermatologists utilizing a broad variety of therapeutic options including cryotherapy, curettage, topical therapies (5FU, imiquimod, and diclofenac), chemical peels and PDT (52,53). ALA‐PDT and 5FU, when applied separately, have given similar clearance response in several clinical trials (54–56). A few studies using a combination of 5FU as a pre‐ or post‐PDT treatment have reported a better lesion clearance rate when 5FU was applied prior to PDT (57–60).…”

Section: Introductionmentioning

confidence: 99%

Combination of 5‐Fluorouracil with Photodynamic Therapy: Enhancement of Innate and Adaptive Immune Responses in a Murine Model of Actinic Keratosis^†

Anand

Heusinkveld

Cheng

et al. 2022

Photochem & Photobiology

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We previously showed that a combination of differentiationinducing agents , vitamin D3 or methotrexate) and aminolevulinate-based photodynamic therapy (PDT) improves clinical responses by enhancing protoporphyrin IX (PpIX) photosensitizer levels and cell death. Here, we show that in addition to its previously known effects, 5FU enhances PDT-induced tumor-regressing immunity. Murine actinic keratoses were treated with topical 5FU or vehicle for 3 days prior to aminolevulinic acid application, followed by blue light illumination (~417 nm). Lesions were harvested for time-course analyses of innate immune cell recruitment into lesions, i.e. neutrophils (Ly6G+) and macrophages (F4/80+), which peaked at 72 h and 1 week post-PDT, respectively, and were greater in 5FU-treated lesions. Enhanced infiltration of activated T cells (CD3+) throughout the time course, and of cytotoxic T cells (CD8+) at 1-2 weeks post-PDT, also occurred in 5FU-treated lesions. 5FU pretreatment reduced the presence of cells expressing the immune checkpoint marker PD-1 at ~72 h post-PDT, favoring cytotoxic T cell activity. A combination of 5FU and PDT, each individually known to induce long-term tumor-targeting immune responses in addition to their more immediate effects on cancer cells, may synergize to provide better management of squamous precancers.

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Section: Introductionmentioning

confidence: 99%

Combination of 5‐Fluorouracil with Photodynamic Therapy: Enhancement of Innate and Adaptive Immune Responses in a Murine Model of Actinic Keratosis^†

Anand

Heusinkveld

Cheng

et al. 2022

Photochem & Photobiology

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Photodynamic application in diagnostic procedures and treatment of non-melanoma skin cancers

Yang,

Li,

Shi

2024

Curr. Treat. Options in Oncol.

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Full-face ALA-PDT for facial actinic keratosis: Two case reports

Zha,

Huang,

Lyu

et al. 2024

Photodiagnosis and Photodynamic Therapy

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Clinical and histopathological study of actinic keratosis treatment with photodynamic therapy VS 5-fluorouracil for face cancerization

Cited by 3 publications

References 23 publications

Combination of 5‐Fluorouracil with Photodynamic Therapy: Enhancement of Innate and Adaptive Immune Responses in a Murine Model of Actinic Keratosis^†

Combination of 5‐Fluorouracil with Photodynamic Therapy: Enhancement of Innate and Adaptive Immune Responses in a Murine Model of Actinic Keratosis^†

Photodynamic application in diagnostic procedures and treatment of non-melanoma skin cancers

Full-face ALA-PDT for facial actinic keratosis: Two case reports

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Clinical and histopathological study of actinic keratosis treatment with photodynamic therapy VS 5-fluorouracil for face cancerization

Cited by 3 publications

References 23 publications

Combination of 5‐Fluorouracil with Photodynamic Therapy: Enhancement of Innate and Adaptive Immune Responses in a Murine Model of Actinic Keratosis†

Combination of 5‐Fluorouracil with Photodynamic Therapy: Enhancement of Innate and Adaptive Immune Responses in a Murine Model of Actinic Keratosis†

Photodynamic application in diagnostic procedures and treatment of non-melanoma skin cancers

Full-face ALA-PDT for facial actinic keratosis: Two case reports

Contact Info

Product

Resources

About

Combination of 5‐Fluorouracil with Photodynamic Therapy: Enhancement of Innate and Adaptive Immune Responses in a Murine Model of Actinic Keratosis^†

Combination of 5‐Fluorouracil with Photodynamic Therapy: Enhancement of Innate and Adaptive Immune Responses in a Murine Model of Actinic Keratosis^†