Clinical and histopathological views of morbilliform rash after COVID-19 mRNA vaccination mimic those in SARS-CoV-2 virus infection-associated cutaneous manifestations

Ohsawa, Risa; Sano, Hozumi; Ikeda, Mitsunori; Sano, Shigetoshi

doi:10.1016/j.jdermsci.2021.06.006

Cited by 24 publications

(33 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Skin biopsies showed a slight lymphocytic perivascular infiltrate [ 34 ]. Finally, in a letter to the editor in June 2021, Risa O. et al showed that mRNA vaccine reactions tended to recapitulate the skin manifestations of SARS-CoV-2 positive subjects, making these data even more interesting having performed skin biopsies, with data similar to those presented in our paper [ 35 ].…”

Section: Discussionsupporting

confidence: 72%

Purpuric Skin Rash in a Patient Undergoing Pfizer-BioNTech COVID-19 Vaccination: Histological Evaluation and Perspectives

et al. 2021

View full text Add to dashboard Cite

The COVID-19 pandemic has affected the entire planet, and within about a year and a half, has led to 174,502,686 confirmed cases of COVID-19 worldwide, with 3,770,361 deaths. Although it is now clear that SARS-CoV-2 can affect various different organs, including the lungs, brain, skin, vessels, placenta and others, less is yet known about adverse reactions from vaccines, although more and more reports are starting to emerge. Among the adverse events, we focused particularly on skin rashes. In this short report, we describe the case of a patient vaccinated with Comirnaty, who developed a purpuric rash resistant to oral steroid therapy after 2 weeks. To date, this is one of the very few cases in which skin biopsy was performed to better characterize the histopathological picture of this rash. Finally, we conduct a literature review of the cases of rashes from SARS-CoV-2 vaccines described in the literature, with the aim of laying foundations for future, larger case studies.

show abstract

Section: Discussionsupporting

confidence: 72%

Purpuric Skin Rash in a Patient Undergoing Pfizer-BioNTech COVID-19 Vaccination: Histological Evaluation and Perspectives

et al. 2021

View full text Add to dashboard Cite

show abstract

“…reported a case of morbilliform rash after COVID‐19 mRNA vaccination, which histologically mimicked COVID‐19 infection‐associated skin lesions. In this case, microthrombi were evident in small vessels of the middle and deep dermis 9 . Together, the data indicate that our case was of GPP flare‐up induced by a COVID‐19 mRNA vaccine.…”

Section: Discussionsupporting

confidence: 58%

Flare‐up of generalized pustular psoriasis combined with systemic capillary leak syndrome after coronavirus disease 2019 mRNA vaccination

Yatsuzuka

Murakami

Kuroo

et al. 2021

The Journal of Dermatology

View full text Add to dashboard Cite

Generalized pustular psoriasis (GPP) is a rare acute variant of psoriasis associated with several systemic complications, including fever, arthralgia, and congestive heart failure. Occasionally, GPP triggers systemic capillary leak syndrome (SCLS), which can have a fatal clinical course. GPP onset or flare-up is often induced by infection, pregnancy, and medications including systemic corticosteroids. However, flareups induced by vaccination are very rare 1 ; only three cases following COVID-19 vaccination have been reported in the English-language literature. 2-4 Herein, we report the first case of GPP flare-up accompanied by SCLS induced by a coronavirus disease 2019 (COVID-19) mRNA vaccine, and review the three published cases without SCLS.

show abstract

“…Morbilliform eruptions have been reported as a cutaneous manifestation of COVID-19 [ 1 ] and as a side effect of mRNA vaccines [ 2 ]. Proposed mechanisms for the development of skin rashes post mRNA vaccines include viral protein expression following vaccination [ 3 ], prior infection with COVID-19 causing cross-reaction with the mRNA vaccine encoded antigen [ 4 ], and vaccine components acting as haptens inducing a Th2 inflammatory reaction characterised by IL-4 and IL-13 expression [ 4 ]. Drug-induced maculopapular eruptions typically resolve within 7–14 days on withdrawal of culprit medication [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Persistent pruritus following COVID-19 vaccination

Doyle

Watchorn

2022

Ir J Med Sci

View full text Add to dashboard Cite

Clinical and histopathological views of morbilliform rash after COVID-19 mRNA vaccination mimic those in SARS-CoV-2 virus infection-associated cutaneous manifestations

Cited by 24 publications

References 10 publications

Purpuric Skin Rash in a Patient Undergoing Pfizer-BioNTech COVID-19 Vaccination: Histological Evaluation and Perspectives

Purpuric Skin Rash in a Patient Undergoing Pfizer-BioNTech COVID-19 Vaccination: Histological Evaluation and Perspectives

Flare‐up of generalized pustular psoriasis combined with systemic capillary leak syndrome after coronavirus disease 2019 mRNA vaccination

Persistent pruritus following COVID-19 vaccination

Contact Info

Product

Resources

About