Clinical and histopathology characteristics of Castleman disease: a multicenter study of 51 Brazilian patients

Leite, Julia Mota; Barrese, Tomás Zecchini; Sementilli, Leonardo; Freitas, Leandro Luiz Lopes de; Santo, Kleber Simões do Espiríto; Delamain, Márcia Torresan; Baiocchi, Otávio César Carvalho Guimarães; Brasil, Sérgio; Chiattone, Carlos S.

doi:10.1007/s00277-023-05116-6

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2024

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Cited by 3 publications

References 27 publications

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Clinicopathological characteristics of unicentric Castleman disease: A single-center experience of 12 patients

Lee,

Lu,

Hsieh

et al. 2024

Journal of the Formosan Medical Association

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Clinicopathological characteristics of unicentric Castleman disease: A single-center experience of 12 patients

Lee,

Lu,

Hsieh

et al. 2024

Journal of the Formosan Medical Association

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Complex Presentation of Multicentric Castleman Disease with Coexisting HIV, HHV‐8, and Other Opportunistic Infections

Tlaiss,

Farhat,

Hasan

et al. 2024

Case Reports in Hematology

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Castleman disease (CD) is a rare lymphoproliferative disorder characterized by benign lymph node enlargement. We present the case of a 43‐year‐old male with a complex medical history, including Crohn’s disease treated with Adalimumab and later complicated with tuberculosis (TB) infection. Subsequently, in May 2021, he was diagnosed with human immunodeficiency virus (HIV) and started on antiretroviral therapy (efavirez, emricitabine, and tenofovir). Despite stropping adalimumab, anti‐Tb, and antiviral therapy, he experienced persistent fever, neurological symptoms, and lymphadenopathy. Toxoplasmosis, Cytomegalovirus (CMV), and Human Herpesvirus‐8 (HHV‐8) were diagnosed and then treated. Furthermore, the patient displayed intermittent febrile episodes, pancytopenia, altered coagulation parameters, hypoalbuminemia, edema, and generalized abdominal pain, as well as radiological evidence of hepatosplenomegaly and pulmonary infiltrates. Left axillary lymph node biopsy (ALNB) was done and confirmed multicentric castleman disease (MCD). Moreover, the bone marrow aspirate showed plasmocytes. His treatment included chemotherapy with doxorubicin and rituximab while continuing his anti‐Tb and antiretroviral therapy. This complex case highlights the diagnostic challenges of managing CD in the presence of multiple coexisting conditions, emphasizing the need for comprehensive evaluation in complex clinical presentations.

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Continuous Therapy in HHV-8 Negative Multicentric Castleman Disease: Pioneering Prolonged Progression-Free Survival

Liu,

Yin,

Ding

et al. 2024

Preprint

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Clinical and histopathology characteristics of Castleman disease: a multicenter study of 51 Brazilian patients

Cited by 3 publications

References 27 publications

Clinicopathological characteristics of unicentric Castleman disease: A single-center experience of 12 patients

Clinicopathological characteristics of unicentric Castleman disease: A single-center experience of 12 patients

Complex Presentation of Multicentric Castleman Disease with Coexisting HIV, HHV‐8, and Other Opportunistic Infections

Continuous Therapy in HHV-8 Negative Multicentric Castleman Disease: Pioneering Prolonged Progression-Free Survival

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