Clinical and Hormonal Variables Related to Bone Mass Loss in Anorexia Nervosa Patients

“…Seventeen studies (27%) sampled regular menstruating participants during the follicular phase of their cycle (de Alvaro et al, 2007;Dostálová et al, 2009;Estour et al, 2017;Galusca et al, 2015;Germain et al, 2010Germain et al, , 2007Germain et al, , 2016Grinspoon et al, 2001;Kaválková et al, 2012;Kirchengast & Huber, 2004;Mayer et al, 2005Mayer et al, , 2009Nakai, Hamagaki, Takagi, Taniguchi, & Kurimoto, 1999;Prioletta et al, 2011;Scalfi et. al, 2002;Weinbrenner et al, 2004), whereas 14 studies (23%) did not provide details about the cycle phase (Bachmann et al, 2014;Bredella et al, 2012;Delporte, Brichard, Hermans, Beguin, & Lambert, 2003;DiVasta et al, 2011;Fazeli et al, 2010;Fernández-Soto et al, 2013;Germain et al, 2010;Gniuli, Liverani, Capristo, Greco, & Mingrone, 2001;Grinspoon et al, 1996;Guo, Jiang, Liao, Liu, & He, 2013;Haas et al, 2005;Karczewska-Kupczewska et al, 2010;Maïmoun et al, 2018;Mörkl et al, 2017;Nakahara et al, 2007;Rigaud, Boulier, Tallonneau, Brindisi, & Rozen, 2010;Tagami et al, 2004;Tanaka et al, 2003). However, studies were retained to achieve the largest possible sample size, and--depending on data availability--meta-regressions were fitted to investigate study characteristics as possible moderators.…”

Section: Results Of the Search And Selection Of Studiesmentioning

confidence: 99%

“…For the analysis of subtypes, posttreatment, and weight-recovered patients with AN, the control groups from the acutely-ill/pretreatment analysis were reused because (a) control groups were not measured repeatedly and (b) none of the studies had separate control groups for each subtype analysis. Although some studies included covariates in their statistical analysis (Bratland-Sanda et al, 2010;Bredella et al, 2008;Dellava, Policastro, & Hoffman, 2009;DiVasta et al, 2007;Fernández-Soto, González-Jiménez, Chamorro-Fernández, & Leyva-Martínez, 2013;Haas et al, 2005;Karlsson, Weigall, Duan, & Seeman, 2000;Kosmiski, Schmiege, Mascolo, Gaudiani, & Mehler, 2014;Maïmoun et al, 2018;Nakahara et al, 2007;Schneider et al, 1998), we only used raw values without including study-specific covariates to increase comparability across individual studies. Weight recovery was defined in accordance with DSM-IV and DSM-5 criteria with BMI >18.5 kg/m 2 or >90% ideal body weight.…”

Section: Meta-analysismentioning

confidence: 99%

Body composition in anorexia nervosa: Meta‐analysis and meta‐regression of cross‐sectional and longitudinal studies

Hübel

Yılmaz

Schaumberg

et al. 2019

Intl J Eating Disorders

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Objective Clinically, anorexia nervosa (AN) presents with altered body composition. We quantified these alterations and evaluated their relationships with metabolites and hormones in patients with AN longitudinally. Method In accordance with PRISMA guidelines, we conducted 94 meta‐analyses on 62 samples published during 1996–2019, comparing up to 2,319 pretreatment, posttreatment, and weight‐recovered female patients with AN with up to 1,879 controls. Primary outcomes were fat mass, fat‐free mass, body fat percentage, and their regional distribution. Secondary outcomes were bone mineral density, metabolites, and hormones. Meta‐regressions examined relationships among those measures and moderators. Results Pretreatment female patients with AN evidenced 50% lower fat mass (mean difference [MD]: −8.80 kg, 95% CI: −9.81, −7.79, Q = 1.01 × 10−63) and 4.98 kg (95% CI: −5.85, −4.12, Q = 1.99 × 10−28) lower fat‐free mass, with fat mass preferentially stored in the trunk region during early weight restoration (4.2%, 95% CI: −2.1, −6.2, Q = 2.30 × 10−4). While the majority of traits returned to levels seen in healthy controls after weight restoration, fat‐free mass (MD: −1.27 kg, 95% CI: −1.79, −0.75, Q = 5.49 × 10−6) and bone mineral density (MD: −0.10 kg, 95% CI: −0.18, −0.03, Q = 0.01) remained significantly altered. Discussion Body composition is markedly altered in AN, warranting research into these phenotypes as clinical risk or relapse predictors. Notably, the long‐term altered levels of fat‐free mass and bone mineral density suggest that these parameters should be investigated as potential AN trait markers. ResumenObjetivo Clínicamente, la anorexia nervosa (AN) se presenta con alteraciones en la composición corporal. Cuantificamos estas alteraciones y evaluamos longitudinalmente su relación con metabolitos y hormonas en pacientes con AN. Método De acuerdo con las pautas PRISMA, realizamos 94 meta‐análisis en 62 muestras publicadas entre 1996–2019, comparando hasta 2,319 pacientes mujeres en pre‐tratamiento, post‐tratamiento, y recuperadas en base al peso con hasta 1,879 controles. Las principales medidas fueron masa grasa, masa libre de grasa, porcentaje de grasa corporal y su distribución regional. Las medidas secundarias fueron densidad mineral ósea, metabolitos y hormonas. Las meta‐regresiones examinaron las relaciones entre esas medidas y moderadores. Resultados Las pacientes femeninas con AN pre‐tratamiento mostraron un 50% menos de masa grasa (MD: −8.80 kg, CI 95%: −9.81, −7.79, Q = 1.01 × 10–63) y 4.98 kg (CI 95%: −5.85, −4.12, Q = 1.99 × 10–28) menos de masa libre de grasa, con masa grasa preferentemente almacenada en la región del tronco durante la recuperación temprana del peso (4.2%, CI 95%: −2.1, −6.2, Q = 2.30 × 10–4). Aunque la mayoría de los rasgos regresaron a los niveles vistos en los controles sanos después de la restauración del peso, la masa libre de grasa (MD: −1.27 kg, CI 95%: −1.79, −0.75, Q = 5.49 × 10–6) y la densidad mineral ósea (MD: −0.10 kg, CI 95%: −0.18, −0.03, Q = 0.01) perm...

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“…4). 10,17,32,[35][36][37][38][39][40][41][42][43][44] Antioxidant-Enhancing Enzymes. Superoxide dismutase levels were significantly lower in ANs than HCs in two studies, 8,41 while one study involving 150 subjects (AN 5 82 and HC 5 68) demonstrated that AN patients had significantly higher catalase levels than HC (1,785 6 407.7 vs. 1,606 6 371.9; p < .0001).…”

Section: Comparison On Patients With An With Healthy Control Subjectsmentioning

confidence: 99%

Oxidative stress and antioxidant levels in patients with anorexia nervosa: A systematic review and exploratory meta‐analysis

Solmi

Veronese

Manzato

et al. 2015

Intl J Eating Disorders

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Clinical and Hormonal Variables Related to Bone Mass Loss in Anorexia Nervosa Patients

Cited by 13 publications

References 27 publications

Bone mineral density, osteoporosis, and fractures among people with eating disorders: a systematic review and meta‐analysis

Bone mineral density, osteoporosis, and fractures among people with eating disorders: a systematic review and meta‐analysis

Body composition in anorexia nervosa: Meta‐analysis and meta‐regression of cross‐sectional and longitudinal studies

Oxidative stress and antioxidant levels in patients with anorexia nervosa: A systematic review and exploratory meta‐analysis

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