Clinical and imaging characteristics of orbital metastatic lesions among Egyptian patients

Eldesouky, Mohammed A.; Elbakary, Molham A

doi:10.2147/opth.s87788

Cited by 17 publications

(26 citation statements)

References 23 publications

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“…Orbital imaging using CT and MRI are the principal means of evaluating orbital lesions. 8 CT scan of the orbits can frequently show the presence of a mass, which often involves the orbital fat or extraocular muscles. 3 CT scans are particularly useful in suspected cases of metastatic tumors with bone involvement.…”

Section: Discussionmentioning

confidence: 99%

“…The mass results in downward displacement of the globe. 8 The accuracy of CT in assessment of stage IIIB-IVB disease is 92%. 9 Definitive diagnosis of an orbital lesion includes an orbital biopsy (either FNA or open biopsy).…”

Section: Discussionmentioning

confidence: 99%

“…1,7 Histology of the orbital mass was similar to the Cervical cancer and reported as Epidermoid Cell Carcinoma moderate differentiation. 8 Eighty percent to 90% of cervical carcinomas are of squamous cell origin, and the tumors are exophytic or primarily endocervical. 9,10 Treatment of orbital metastases in particular is usually palliative and consists of radiation therapy with or without steroids and chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…4 Eye metastases from cervical cancer are extremely rare but are known to occur; the orbit that is the extraocular muscles and the subconjunctival tissue being the reported sites of metastatic lesions. [3][4][5]8 The orbit is an unusual site for metastatic cancer, approximately 2%-3% of patients with systemic cancer. 8…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5]8 The orbit is an unusual site for metastatic cancer, approximately 2%-3% of patients with systemic cancer. 8…”

Section: Introductionmentioning

confidence: 99%

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Metastasis of Epidermoid Cervical Carcinoma Cell to The Orbit

Widiastuti

Rahayu

Susianto

et al. 2018

Indonesian Journal of Cancer

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Orbital metastases of cervical cancer cell are very rare. There is only one case reported in Dr. Moewardi Public Hospital Surakarta between 1999 and 2017. A 45-year-old woman was admitted with the upper right orbital lesion. She had not received a routine gynecologic examination for more than 10 years. She had normal chest X-ray. Abdominal ultrasonography revealed a heteroechoic lesion poor defined edge in cervix utery expands to corpus utery and rectum. Bilateral uropathy obstruction occured. Bone survey demonstrated osteolytic bone metastasis in the right supra orbital bone and a compression fracture of the twelfth thoracal spine. Head and orbital Computed Tomography (CT) scan, which revealed multiple metastatic lesions in the right orbital expanding to extra cranial, was performed. Our diagnosis was cervical cancer FIGO IV-B stage with distant metastasis thus chemoradiation was given. The aim of this report is to give more references regarding this complicated clinical condition. ABSTRAKKanker serviks metastasis ke orbita sangat jarang terjadi. Hanya satu kasus yang dilaporkan di Rumah Sakit Umum Daerah Dr. Moewardi Surakarta antara tahun 1999 - 2017. Seorang wanita usia 45 tahun dirawat oleh karena lesi di orbita kanan atas sejak 2 bulan yang lalu. Pasien tersebut belum pernah mendapatkan pemeriksaan kandungan rutin selama lebih dari 10 tahun. Foto Chest X Ray normal. Ultrasonografi abdomen tampak lesi heteroekoik batas tak tegas pada serviks uterus meluas ke korpus uterus dan rektum. Terjadi obstruksi uropati kanan dan kiri. Bone survei memperlihatkan gambaran metastasis tipe litik pada tulang supra orbita kanan dan fraktur kompresi pada tulang belakang toraks ke dua belas. Computed Tomography (CT) Kepala dan Orbita memperlihatkan beberapa lesi metastasis pada supra orbita kanan yang meluas ke tulang tengkorak. Diagnosis kami adalah kanker serviks tahap FIGO IV-B dengan metastasis jauh dan diberikan therapi kemoradiasi. Tujuan penulisan ini adalah untuk memberikan lebih banyak referensi data tentang kondisi klinis yang rumit ini.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…[3][4][5]8 The orbit is an unusual site for metastatic cancer, approximately 2%-3% of patients with systemic cancer. 8…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Metastasis of Epidermoid Cervical Carcinoma Cell to The Orbit

Widiastuti

Rahayu

Susianto

et al. 2018

Indonesian Journal of Cancer

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Ocular involvement in metastatic and systemic malignancies is not rare

Sthapit

Saiju

2021

Cancer Reports

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Background: Metastatic disease to the eye most commonly involves choroid followed by orbit leading to varied ocular manifestations. By comparison, it is relatively rarer than primary malignancies of eye as well as metastasis in other parts of the body. Aim:The aim of this study is to evaluate the common eye and orbital structures involved in secondary ocular and metastatic disease, to describe its clinical manifestations and outline the management done.Methods: A retrospective study of newly diagnosed cases of ocular metastasis in last 2 years conducted in our recently established department of ocular oncology at a tertiary eye care hospital in Nepal. Demography, age and sex distribution were noted.The patients were segregated into those with secondary or metastatic ocular malignancies. Detail study on the metastatic disease to eye was made in regards to presenting symptoms, signs, primary site of cancer, and the treatment done. Details of the investigations done, like biopsy and imaging were also recorded.Results: There were a total of 28 patients, whose age group ranged from 9 years to 69 years with median age of 43 years. Females constituted 46% of total patients. Both the eyes were involved in 9 patients (32%). Eye was secondarily involved by paranasal sinus tumors and Non Hodgkin lymphoma (7 patients each). Ocular metastasis was commonly seen from broncogenic carcinoma in four and breast carcinoma in three patients. Simultaneous metastasis to other parts of the body was also seen in 61% of our patients. Diminution of vision in 49% was the most common presenting feature followed by proptosis in 16% and palpable mass in 14% of patients.Orbit in 43% cases is the commonest ocular structure involved. Histopathologic diagnosis was done in 32% only while rest was based on imaging alone. The most common treatment done was chemotherapy in 57% patients. Conclusion:Ocular metastasis can display a wide variety of clinical and imaging features and therefore a high degree of suspicion is required. It is often associated with simultaneous metastasis to other parts of the body as well, hence the importance of earlier diagnosis and metastatic workup.

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Clinical characteristics, diagnosis, and outcomes of orbital biopsies in a single Irish centre

et al. 2022

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Aims To review the distribution of histopathological diagnoses and visual outcome of orbital biopsy in an Irish tertiary referral centre over a 10-year period. Methods This was a retrospective, clinical-histopathological case series. Clinical records of all patients who underwent orbital biopsy between January 2008 and January 2018 in the Mater Misericordiae University Hospital were reviewed using data collected from theatre logbooks and hospital-based medical records. Results A total of 83 orbital biopsies in 77 patients were included for analysis in this study. The mean age was 55.7 ± 18.41 years. The mean follow-up period was 1.87 ± 2.097 years. The most common presenting symptoms and signs were pain (22.3%) and proptosis (27.6%). Most lesions were located in the extraconal space (65%), with incisional biopsy (65%) being the most common technique used to gain a sample for histopathological diagnosis. Histopathology analysis of the biopsies revealed malignant tumours (27, 32.5%), benign tumours (7, 8.4%), inflammation (26, 31.3%), and other diagnoses (23, 27%). Excluding patients who underwent exenteration procedures, no study patients suffered visual loss following orbital biopsy. Conclusions Orbital biopsy serves as a safe diagnostic tool in managing orbital diseases. The breakdown of diagnosis in our patients is in line with international studies. No patients in our series suffered vision loss as a result of their orbital biopsy. This emphasises its use as a safe procedure in the diagnosis and management of patients with the orbital disease. Our data provides helpful guidance to clinicians when counselling patients for orbital biopsy.

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Clinical and imaging characteristics of orbital metastatic lesions among Egyptian patients

Cited by 17 publications

References 23 publications

Metastasis of Epidermoid Cervical Carcinoma Cell to The Orbit

Metastasis of Epidermoid Cervical Carcinoma Cell to The Orbit

Ocular involvement in metastatic and systemic malignancies is not rare

Clinical characteristics, diagnosis, and outcomes of orbital biopsies in a single Irish centre

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