Clinical and imaging features of carcinosarcoma of the uterus and cervix

Abstract

Aim The purpose of our study was to analyze the clinical and imaging features of uterine carcinosarcoma (UCS) and cervical carcinosarcoma (CCS), and to explore the diagnostic and staging accuracy of computed tomography (CT) and magnetic resonance imaging (MRI) examinations. Methods 41 patients including 37 with UCS and 4 with CCS from July 2011 to September 2020 were enrolled in the study. Of the 37 UCS cases, 7 had CT images, 27 had MRI images, and 3 had both CT and MRI images. The Clinical data, CT or MRI imaging findings were analyzed. Diagnosis and staging accuracy of CT and MRI images were also analyzed. Results Carcinosarcoma usually occurs in postmenopausal women (40/41), with the typical clinical symptom being vaginal bleeding (33/41). The CA125 degree was significantly different between the two invasion depth groups (p = 0.011). Most uterine carcinosarcomas showed unclear boundaries, uneven density, low or equal signal on T1WI, high or mixed signal on T2WI, uneven high signal on diffusion-weighted image (DWI), and mild enhancement. The diagnostic accuracies of CT and MRI for carcinosarcoma were 0% and 3.33%, respectively. The diagnostic accuracy for malignant tumors on CT and MRI was 50% and 83.33%, respectively. Conclusions Carcinosarcoma lesions presented with huge mass filling in the cavity, and some presented with small polypoid lesions or endometrial thickening. Evaluation of lymph node metastasis is a significant challenge for imaging staging.

Prediction of lymph node metastasis in operable cervical cancer using clinical parameters and deep learning with MRI data: a multicentre study

“…The results showed that the probability of LNM in patients with an LN short diameter ≥ 10 mm was significantly higher than that in patients with an LN short diameter < 10 mm. However, judging lymph node metastasis only by shape and size will lead to some false negatives [ 26 ]. Eighty-nine patients in our cohort showed that the LN max was < 10 mm, but postoperative pathology confirmed that the lymph nodes were positive.…”

Carcinosarcoma of uterus

“…The staging method of the International Federation of Gynecology and Obstetrics or the Tumor, Node, Metastasis classification system should be used to interpret this malignancy because it is categorized as endometrial carcinoma. MRI has a 70% staging accuracy rate [15] .…”

Malignant giant cell tumors of the tendon sheath of the right hip: A case report

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