Clinical and immunohistochemical evaluation of the vulvar Langerhans cell histiocytosis

Abstract

Psoriasis and psoriatic arthritis are common diseases associated with considerable morbidity and disability. Their pathophysiology comprises similar processes leading to inflammation of skin, entheses, and joints. Although traditional systemic agents can be effective, their use may be limited by lack of efficacy and concerns regarding adverse effects. The objective of this study was to assess the efficacy and safety of adalimumab, a fully human antitumor necrosis factor (anti-TNF) monoclonal antibody, over 16 weeks. The present authors report their personal experience in 15 patients with severe plaque psoriasis and psoriatic arthritis, refractory to other treatments, in which a decisive regression of joint/skin involvement was obtained. Psoriasis and psoriatic arthritis are chronic inflammatory disorders resulting from a combination of genetic and environmental factors.

Langerhans cell histiocytosis of bone in children: a clinicopathologic study of 108 cases

“…It has been suggested that these pathological LCs may be blocked in the activation or differentiation state of normal LCs, [8] so the shape of LC in LCH lack the thin-fi nger dendritic processes of normal LCs and display ovoid to round morphology. [9] Gong [10] has divided these pathologic LCs into four types: (1) typical LC, 12-15 μm in diameter with pale eosinophilic cytoplasm and ovoid or round deep-grooved nuclei without a nucleolus; (2) monocytelike LC, similar to typical LC but with relatively regular nuclei; (3) multinucleated giant LC, with large, abundant cytoplasm and multiple typical-LC-like nuclei; and (4) large-round LC, with large, abundant cytoplasm and large round nuclei with 1-2 small red nucleoli. In our study, the majority of LCs in every lesion were categorized into typical LCs.…”

“…[3] In addition, there are various kinds of infl ammatory cells in LCH lesion, which produce cytokines to help develop LCH. [9] Among these inflammatory cells, eosinophils are easily seen. They often accumulate in clusters and even form eosinophilic abscess.…”

“…The lesion sites were as follows: ilium (27 patients), femur (21), tibia (17), skull (17), clavicle (9), sternum (4), cervical vertebra (3), ulna (3), humerus (2), metacarpal bone (2), hip bone (2), and fibula (1). There were 79 patients with single bone involvement, 26 patients with involvement of 2 bones, 1 patient with involvement of 3 bones, and 2 patients with multiple organ system involvement (bone, liver, spleen, skin, and lymph nodes).…”

Cutaneous histiocytic sarcoma with E-cadherin expression in a Pembroke Welsh Corgi dog

“…11 Various kinds of inflammatory cells such as lymphocytes, eosinophils, macrophages, and plasma cells infiltrate the Langerhans cell histiocytosis lesions, which produce cytokines to facilitate development of Langerhans cell histiocytosis. 3 The present case had an onset of this neoplastic disease in adulthood, showing malignant histological and cytologic features such as high mitotic rate and extensive necrosis. There were no inflammatory cells in tumor tissue of the present case.…”

Avaliação das células de Langerhans na língua de pacientes autopsiados com AIDS em estágio avançado

“…As células de Langerhans localizam-se preferencialmente na epiderme e constituem cerca de 3% de todas as células epidérmicas (Babi, 1998). Estão presentes no epitélio estratificado escamoso, onde estão largamente distribuídas na camada basal e suprabasal desse epitélio, incluindo tecidos da boca, faringe e esôfago (Cutler & Jotwan, 2004) e não apresentam turnover alto (Bongiorno et al, 2008).…”