Clinical and immunologic evaluation of glutaraldehyde-modified, tyrosine-adsorbed short ragweed extract: a double-blind, placebo-controlled trial

Immunotherapy as an effective tool in allergy treatment

“…Most immunotherapy studies investigated the efficacy of pollen allergies. These studies can be subdivided into 13 studies (5,7,9,11,12,15,17,19,22,32,35,36,39) investigating ragweed allergy (nine showing clinically relevant efficacy, i.e., symptom/medication scores diminished by >30% in the actively treated). Fifteen studies investigated the efficacy of immunotherapy in grass-pollen allergy (8,13,16,18,20,21,23,25,30,34,37,38,40,44,47), of which 14 proved efficacy.…”

Improvement of specific immunotherapy by human IgG and modified allergens

“…The superiority compared with placebo has been established in a number of investigations for ragweed (25,27,31,61) and grass pollen (26,30). In a comparison between native aqueous grass pollen extract and glutaraldehyde-polymerized extract patients noted a lower degree of improvement which coincided with a lower rise of IgG-antibodies in the polymer-group.…”

“…Adsorption to tyrosine has also been combined with glutaraldehyde-polymerized extracts as described below (38,61).…”

Adjuvant Properties of Hydrophobic Derivatives Prepared from <i>L</i>-Tyrosine

“…3 Days after initial injection. 4 Series A and B were carried out independently 5 C -Coprecipitation procedure; A = addition procedure (see Materials and Methods). 6 Range of group responses (reciprocal titres).…”

“…These attributes, coupled with the readily metabolisable nature of the naturally occurring amino acid, have been exploited for clinical use in hyposensitisation therapy as a de pot vaccine presentation form [1][2][3][4]. Adjuvant prop erties of L-tyrosine for the production of IgG anti body in experimental animals have also been demon strated [5].…”