Clinical and immunological charactereistics...

Abstract

The search of new predictor markers for disease outcomes and treatment efficacy is crucial for metastatic sarcoma, where prognosis is unfavourable and the choice of chemotherapy is limited. In our work we present the results of in vitro clonogenic abilities study of tumor cells connection with immunological parameters of peripheral blood and survival rate of patients with metastatic soft tissue sarcomas and bones sarcomas (STBS). Keywordssarcoma, clonogenic potential, immunological indicatorsMotivation and aim Today the state of the immune cellular link is widely discussed as a predictor of the response to immunotherapy. It is undoubted interest for sarcoma, where the effectiveness of chemotherapy is low and prognosis is unfavorable, especially in the development of metastatic disease [1]. Genetic, histological and morphological diversity of different clones inside the tumor and peculiarities of their relations with the patient's immune system mainly presented on tumors models with epithelial origin. Tumours with mesenchymal origin, such as STBS, haven't been sufficiently studied in this regard. Cloning with the limiting dilution method demonstrates the presence of self-regulating tumor cells in the population and can serve as an independent predictor of adverse prognosis.