Clinical and immunological status of children with lyme disease

Nykytyuk, S.О.; Klymnyuk, S. I.

doi:10.5114/hpc.2021.108379

Cited by 1 publication

(2 citation statements)

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“…The following combined groups of pathogens were identified: B. burgdorferi s.l. with A. phagocytophilum and B. miyamotoi with A. Phagocytophilum [8,9].…”

Section: Methodsmentioning

confidence: 99%

“…The cause of Lyme arthritis, which was observed in 10 (16.13 %) children, is the consequences of immunopathological autoimmune reactions manifested by the development of synovitis with characteristic morphological changes, including synovial cell hyperplasia, nonspecific hypertrophy of villi, lymphoplasmacytic cell infiltration, follicle formation, and fibrin deposition. It is known that Borrelia burgdorferi antigens remain in the cartilage for a long period after etiological therapy and contribute to the stimulation of tumour necrosis factor alpha synthesis from macrophages, which leads to chronicity of the process in the joints [8]. In children with Lyme arthritis, its torpid course was observed.…”

Section: Methodsmentioning

confidence: 99%

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Features of the Algorithm of Clinical and Laboratory Diagnosis of Lyme Borreliosis in Children

Hospodarskyy,

Levenets,

Horishnyi

et al. 2024

АПП

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The aim of the study – to improve the algorithm of clinical and laboratory diagnosis of Lyme borreliosis in children. Materials and Methods. The search and analysis of available literature sources of the PubMed database is carried out, using a combination of keywords "Lyme disease in children", " Clinical and Laboratory diagnostic". A group of children (62) aged 1 to 17 years was observed to identify pathogens of haemotransmissible infections among children. C-reactive protein (CRP) was determined, which is a protein and reagent of the acute phase. To confirm the diagnosis of PM, determine the form of the lesion and identify the antigens of the pathogen, a routine two-step method of blood analysis was used. Results and Discussion. The algorithm for the diagnosis of Lyme borreliosis in children has been developed for use in making a diagnosis. Clinical: complaints – malaise, fatigue, headache, arthralgia, myalgia, subfebrile body temperature; anamnesis – tick bites, location of bites, time of appearance of symptoms after the bite; objective – lymphadenopathy, arthritis, pain syndrome, intoxication syndrome; laboratory and instrumental diagnostics: biochemical blood analysis (increased level of C-reactive protein, rheumatoid factor is rarely detected), ultrasound of joints, immunological examination (immunofluorescence analysis and blot test), detection of Borrelia by PCR method in synovial fluid. Conclusions. Proposed algorithm for diagnosing the Lyme disease in children.

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“…The following combined groups of pathogens were identified: B. burgdorferi s.l. with A. phagocytophilum and B. miyamotoi with A. Phagocytophilum [8,9].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%