Clinical and laboratory assessment for the inflammation role in chronic spontaneous urticaria: A clinical study

Abstract

Chronic spontaneous urticaria (CSU) is triggered by unknown causes. We would like to explore the possible effect of hemogram parameters and several biochemical markers on CSU presence and also the severity of the disease. We also aimed to discuss the relationship between CSU and inflammation associated with these values. The study was planned prospectively. We selected patients already diagnosed with CSU who applied to the dermatology outpatient clinic and healthy controls. The patients and the healthy controls were tested for complete blood count, neutrophil/lymphocytes ratio and platelets/lymphocytes ratio, erythrocyte sedimentation rate, C-reactive protein, serum albumin and total bilirubin and indirect bilirubin levels. Urticaria activity score over 7 days (UAS-7) was calculated for the CSU patients. Forty patients with CSU and 55 healthy subjects were included in the study. Mean white blood cell (WBC) count is 8.37 ± 2.14 in the patients' group and 7.41 ± 2.01 in the healthy subjects group. Mean neutrophil (NEU) count is 4.88 ± 1.65 in the patients' group and 4.19 ± 1.39 in the healthy subjects group. Mean platelets (PLT) count is 308.48 ± 88.32 in the patients' group and 268.65 ± 64.80 in the healthy subjects group. We also detected positive correlations between UAS-7 score-WBC counts and UAS-7 score-NEU counts. Future studies are needed to investigate this possible relationship and confirm these results.

Bilirubin as a new antioxidant in melasma

“…13 However, serum levels of Bil were reported as normal in some other dermatological disorders such as lichen planus and chronic spontaneous urticaria. 8,22 In humans, over half of the antioxidant capacity of blood plasma comes from uric acid. In other words, UA is the most potent antioxidant in the plasma due to its properties to detoxify a wide range of oxidants including hydroxyl radicals, superoxide anion, hydrogen peroxide, and peroxy nitrite.…”

A newly identified myokine: irisin, and its relationship with chronic spontaneous urticaria and inflammation

“…Serum irisin levels have previously been investigated in obesity, chronic kidney disease, T2DM, metabolic syndrome, inflammatory disease, and various types of cancer [ 3 , 19 – 25 ]. Ataseven et al showed significantly higher WBC, NEU, and PLT counts in groups with CSU than in healthy controls, although CRP levels were higher in the healthy control group [ 26 ]. NOD-like receptor protein 3 (NLRP3) mutation was detected and Muckle–Wells syndrome (MWS) was diagnosed in a man with a 15-year history of CSU in a recent case report study.…”

“…Irisin, IL-2, IL-3, IF-ɣ, TNF-α concentrations of CU and control groups Ataseven et al showed significantly higher WBC, NEU, and PLT counts in groups with CSU than in healthy controls, although CRP levels were higher in the healthy control group[26]. NOD-like receptor protein 3 (NLRP3) mutation was detected and Muckle-Wells syndrome (MWS) was diagnosed in a man with a 15-year history of CSU in a recent case report study.…”

Does omalizumab use in chronic spontaneous urticaria results in improvement in sexual functions?

“…It is divided into chronic spontaneous urticaria (CSU) which has no known causes and chronic inducible urticarias (CIndU) or physical urticarias triggered by such factors 1 . If autoantibodies or unknown factors trigger the disease, it is named as CSU 2 . CSU usually negatively affects the social relations, sleep quality, work performance, and quality of life (QoL) of the patients 3 .…”

“…1 If autoantibodies or unknown factors trigger the disease, it is named as CSU. 2 CSU usually negatively affects the social relations, sleep quality, work performance, and quality of life (QoL) of the patients. 3 CSU can also affect sexual life of the patients.…”