Clinical and Laboratory Features of Severe Acute Respiratory Syndrome Vis-À-Vis Onset of Fever

Liu, Ching-Lung; Lu, Yen‐Ta; Peng, Meng-Jen; Chen, Pei-Jan; Lin, Rong-Luh; Wu, Chien‐Liang; Kuo, Hsu-Tah

doi:10.1378/chest.126.2.509

Cited by 64 publications

(60 citation statements)

References 22 publications

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“…Au cours des infections à paramyxovirus comme la rougeole et au cours des infections à cytomégalovirus (CMV), une lymphopénie est en règle associée à un plus mauvais pronostic [26]. Une lympho-ménie peut également être observée au cours des infections à virus respiratoire syncitial (VRS), à virus West-Nile ou à coronavirus, responsable du SARS [27]. La lymphopénie pourrait être la conséquence d'un excès d'apoptose lymphocytaire et/ou d'une élévation du cortisol plasmatique.…”

Section: Infectionsunclassified

Orientation diagnostique devant une lymphopénie

et al. 2006

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Lymphopenia is defined as a peripheral lymphocyte count lower than 1500/mm3 in adults and 4500/mm3 in children younger than eight months of age. We propose a classification of lymphopenia according to the mechanism involved: lymphocyte production defects, including primary immune deficiencies and immune deficiencies secondary to malnutrition or zinc deprivation; excess catabolism, due to causes including radiotherapy, chemotherapy, immunosuppressive therapy, HIV infection, and systemic lupus erythematosus; abnormal lymphocyte trapping, including mainly splenomegaly, certain viral infections, septic shock, extended burns, systemic granulomatosis, and corticosteroids; other causes of lymphocytopenia, with mechanisms that remain poorly understood: ethnicity (Ethiopians), lymphoma, renal insufficiency, and idiopathic CD4 lymphocytopenia.

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Section: Infectionsunclassified

Orientation diagnostique devant une lymphopénie

et al. 2006

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“…Background SARS is a virus spread by close contact with nonspecific presentation. Patients generally exhibit a fever of over 100.4 1F, a dry cough, diarrhea, vomiting, and eventually pneumonia (Fan et al, 2006;Liu et al, 2004). From the first known case in November 2002 to its containment in summer 2003, mounting infections and deaths from this unfamiliar disease caused fear and economic disruption as the virus spread from Guangdong, China, to Hong Kong, Vietnam, and other countries including Canada.…”

Section: Introductionmentioning

confidence: 99%

SARS and New York's Chinatown: The politics of risk and blame during an epidemic of fear

Eichelberger

2007

Social Science & Medicine

199

171

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This paper examines the production of risk and blame discourses during the 2003 SARS epidemic and responses to those messages in New York City's Chinatown, a community stigmatized during the SARS epidemic despite having no SARS cases. The study consisted of 6 weeks participant observation and 37 semi-structured, open-ended interviews with community members. Stigmatizing discourses from the late 19th century resurfaced to blame Chinese culture and people for disease, and were recontextualized to fit contemporary local and global political-economic concerns. Many informants discursively distanced themselves from risk but simultaneously reaffirmed the association of Chinese culture with disease by redirecting such discourses onto recent Chinese immigrants. Legitimizing cultural blame obfuscates the structural and biological causes of epidemics and naturalizes health disparities in marginalized populations. This research demonstrates that myriad historical, political, and economic factors shape responses and risk perceptions during an unfamiliar epidemic, even in places without infection.

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“…We have described a better clinical outcome after SARS in 4 HCWs compared with 12 non-HCWs; despite all having been involved in a cluster related to one index patient, with 13 apparently directly infected by that patient and 3 others by secondary transmission. In several previous reports on SARS, HCWs were less likely to die than non-HCWs (9,13,21). Possible reasons for this may be that they were often younger than non-HCWs, sought treatment earlier, and were less likely to have coexisting illnesses (especially diabetes mellitus and heart disease) (11,13,14,17).…”

Section: Discussionmentioning

confidence: 95%

Viral load and outcome in SARS infection: The role of personal protective equipment in the emergency department

Chen

Sheu

et al. 2006

The Journal of Emergency Medicine

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This study was conducted to evaluate the effectiveness of personal protective equipment (PPE) against severe acute respiratory syndrome (SARS). Sixteen patients in a SARS cluster, including 4 health care workers (HCWs) and 12 non-HCWs were studied. We compared the initial viral load by nasopharyngeal swabs, clinical progression, and outcome of this cluster. The HCWs had a lower viral load. The non-HCWs had a higher mean C-reactive protein, lower oxygen saturation, and a higher incidence of intubation and death. Secondary household transmission developed in three of the non-HCWs' families. One month after discharge, non-HCWs had more signs of fibrosis on high resolution computed tomography (HRCT) scan and an impaired pulmonary function test. Although most of the PPE do not confer absolute protection against SARS, it seems that they may lower exposure to the virus, leading to a lower risk of secondary transmission, and be associated with relatively mild disease and a better early outcome.

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Clinical and Laboratory Features of Severe Acute Respiratory Syndrome Vis-À-Vis Onset of Fever

Cited by 64 publications

References 22 publications

Orientation diagnostique devant une lymphopénie

Orientation diagnostique devant une lymphopénie

SARS and New York's Chinatown: The politics of risk and blame during an epidemic of fear

Viral load and outcome in SARS infection: The role of personal protective equipment in the emergency department

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