Clinical and Laboratory Predictors of Severity, Criticality, and Mortality in COVID-19: A Multisystem Disease

Gholami, Bahareh; Gholami, Samira; Loghman, Amirhossein; Khodaei, Behzad; Seyedpour, Simin; Seyedpour, Nasrin; Saghazadeh, Amene; Rezaei, Nima

doi:10.1007/978-3-030-63761-3_22

Cited by 4 publications

(2 citation statements)

References 113 publications

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“…Results from this study also show this association; a positive correlation between IL-6 and percentages of granulocytes was found. Leucopenia, lymphopenia, and neutrophilia are usually seen in viral infections [16,[40][41][42] and in COVID-19 [7,43] which was also confirmed in this study. Neutrophilia indicates the intensity of inflammatory response, while lymphopenia suggests the damage to cells of the immune system [37].…”

Section: Discussionsupporting

confidence: 89%

Biomarkers of Inflammation among Patients with COVID-19: A Single-Centre Prospective Study from Prishtina, Kosovo

Latifi-Pupovci

Namani

Ahmetaj‐Shala

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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SARS-CoV-2 infection involves the phase of viral replication and inflammatory response predicting the severity of COVID-19. The aim of the study was to analyze the association between IL-6 and hematological and inflammatory parameters and outcomes of patients with COVID-19. Plasma interleukin 6 (IL-6) levels and other inflammatory and hematological parameters were analyzed in 86 adult patients diagnosed with SARS-CoV-2 infection in Kosovo. The median age of patients was 61.50 (49.75–67.25) years. Over half of patients were categorised as severe (58%) and had comorbidities (69%) with hypertension being the most common. The overall mortality rate was 4.7%. The distribution of biochemical parameters across disease severity groups was significantly different for C-reactive protein (CRP), lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), white blood cells (WBC), and granulocytes with higher median values in more severe and critically ill patients whereas lower percentage of lymphocytes, monocytes, and platelet count in severe and critically ill patients. IL-6 levels were increased in 63% of patients with significant differences in the distribution across the following groups; age, disease severity, hospitalisation status, pulmonary infiltrates, oxygen therapy, and hypertension status. IL-6 significantly correlated with CRP, LDH, CK, ESR, and percentages of granulocytes. IL-6 and other inflammatory and hematological parameters were strongly associated with disease severity and may predict the outcome of the SARS-CoV-2 infection.

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Section: Discussionsupporting

confidence: 89%

Biomarkers of Inflammation among Patients with COVID-19: A Single-Centre Prospective Study from Prishtina, Kosovo

Latifi-Pupovci

Namani

Ahmetaj‐Shala

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…Additional markers of inflammation such as LDH, d-dimers, and ferritin, used in part to classify the severity of the infection and also for prognostic purposes [7], were not requested following the positive test result of our patient because of cost to the patient. We felt that, although these tests were useful for determining the severity of COVID-19, we could also judge the severity of the patient's illness from the clinical presentation, physical examination, and also from the basic laboratory parameters [8].…”

Section: Laboratory Resultsmentioning

confidence: 99%

Coronavirus disease 2019 presenting as psychosis: a case report

Lovi¹,

Kekrebesi²,

Osei³

et al. 2022

J Med Case Reports

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Background The coronavirus disease 2019 syndrome typically consists of respiratory symptoms and other general nonspecific symptoms. Psychotic manifestations of coronavirus disease 2019 attributable to severe acute respiratory syndrome coronavirus 2 infection are seldom reported. We report a case of coronavirus disease 2019 in a young West African male who had no known risk factors of psychiatric illness or past history of psychiatric disease presenting with acute psychosis. Case presentation Our patient, who was a young West African male, presented without the typical respiratory symptoms of coronavirus disease 2019 and also without a background history of psychiatric illness or any other significant stressors in his past or present social history. He had acute onset of psychotic symptoms consisting of visual and auditory hallucinations, delusions of persecution, and lack of insight. He was admitted and managed with antipsychotic medication and mood stabilizer. His laboratory workup was normal except for positive coronavirus disease 2019 polymerase chain reaction and his liver enzymes, which showed elevated gamma glutamyl transferase, a finding consistent with coronavirus disease 2019. His head computed tomography scan was also normal. The patient made a gradual recovery from his psychotic symptoms, with gain of insight 7 weeks after onset of symptoms, at which time his coronavirus disease 2019 test came back negative along with other laboratory parameters. He returned to work 12 weeks after his presentation and has been performing well. Conclusion Psychosis can be a primary presenting symptom in patients with coronavirus disease 2019, including those without respiratory symptoms.

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Mental Healthcare in Pediatrics During the COVID-19 Pandemic: A Call for International Public Health Action

Aleebrahim-Dehkordi,

Soveyzi,

Deravi

et al. 2024

Advances in Experimental Medicine and Biology

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Clinical and Laboratory Predictors of Severity, Criticality, and Mortality in COVID-19: A Multisystem Disease

Cited by 4 publications

References 113 publications

Biomarkers of Inflammation among Patients with COVID-19: A Single-Centre Prospective Study from Prishtina, Kosovo

Biomarkers of Inflammation among Patients with COVID-19: A Single-Centre Prospective Study from Prishtina, Kosovo

Coronavirus disease 2019 presenting as psychosis: a case report

Mental Healthcare in Pediatrics During the COVID-19 Pandemic: A Call for International Public Health Action

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