Clinical and laboratory profile of children with COVID-19 admitted at a tertiary care hospital in Karnataka, Southern India

Sahana, K S; Prabhu, Anitha S.; Saldanha, Prema; Sudhir, Shyam; Gurmitkal, Balakrishna

doi:10.4038/sljch.v50i3.9733

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…Severe illness was seen in about 9% of children in our study, whereas in a study by Nallasamy K, et al 11 , it was almost double. Sahana KS, et al 14 found that 25% of children had some comorbidity, which was almost similar to our study (28%) and this may be partly attributed to the fact that both studies were conducted in the same geographical area. Nallasamy K, et al 11 found that severe illnesses were more in infants with comorbidities.…”

Section: Discussionsupporting

confidence: 90%

Clinical profile of Covid-19 in children: Study from a Medical College Hospital in Mangalore, Karnataka, India

John

Avabratha

Shanbhag

2022

Sri Lanka J Child Health

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Introduction: India reported its first case of coronavirus disease 2019 (Covid-19) on 30th January 2020. During the first wave, it was noted that older individuals with comorbidities were mainly affected and in the second wave younger people including children were also affected.Objectives: To assess the clinico-epidemiological profile, investigations and outcomes in children admitted with Covid-19 to a Medical College Hospital in Mangalore, Karnataka, India and to compare the first and second waves. Method:In this ambispective descriptive study, all patients below 18 years of age with a confirmed diagnosis of Covid-19 or Multisystem Inflammatory Syndrome in Children (MIS-C), admitted to a Medical College Hospital in Mangalore, Karnataka, India from April 2020 to July 2021 were included. Epidemiological data, symptoms, clinical management and outcomes were noted and the differences between the two waves were assessed.Results: A total of 64 children (27 from the first wave and 37 from the second wave) were included; 25 (39%) children were exposed to a Covid-19 suspect with parents being the major source. The age groups mainly affected were 1-5 years (30%) and 11-18 years (27%); 56 (87%), 3 (5%) and 5 (8%) had mild, moderate and severe Covid-19 respectively and there was one death; 39 (61%) had fever, 13 (20%) had febrile convulsions and 3 were coinfected with dengue; 25 (40%) children were admitted to the intensive care unit (ICU), of whom 9 _________________________________________ 1

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Section: Discussionsupporting

confidence: 90%

Clinical profile of Covid-19 in children: Study from a Medical College Hospital in Mangalore, Karnataka, India

John

Avabratha

Shanbhag

2022

Sri Lanka J Child Health

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“…The need for invasive ventilation has ranged from 4.1 to 47% [ 11 – 14 , 18 , 21 , 28 , 29 ] in different studies similar to the authors’ observations. About a fifth of the children, in the present study, required noninvasive respiratory support, the need being higher particularly during the second wave.…”

Section: Discussionsupporting

confidence: 83%

“…The proportion of illness severity reported among hospitalized children greatly varies among different studies and ranges from 0.5%–79.3% for moderate, 0–42% for severe and 9%–34% for critical disease. Studies in children admitted to intensive care settings, expectedly, had a higher proportion of severe disease [ 11 , 17 , 18 , 25 – 27 ]. The interpretation of severity of illness is inconsistent, as many studies have not distinguished children with symptomatic COVID-19 from those admitted with another unrelated illness but having incidental SARS-CoV-2 infection.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology, Clinical Profile, Intensive Care Needs and Outcome in Children with SARS-CoV-2 Infection Admitted to a Tertiary Hospital During the First and Second Waves of the COVID-19 Pandemic in India

et al. 2022

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Objectives To compare the epidemiological, clinical profile, intensive care needs and outcome of children hospitalized with SARS-CoV-2 infection during the first and second waves of the pandemic. Methods This was a retrospective study of all children between 1 mo and 14 y, admitted to a dedicated COVID-19 hospital (DCH) during the first (1st June to 31st December 2020) and second waves (1st March to 30th June 2021). Results Of 217 children, 104 (48%) and 113 (52%) were admitted during the first and second waves respectively. One hundred fifty-two (70%) had incidentally detected SARS-CoV-2 infection, while 65 (30%) had symptomatic COVID-19. Comorbidities were noted in 137 (63%) children. Fifty-nine (27%) and 66 (30%) children required high-dependency unit (HDU) and ICU care respectively. Severity of infection and ICU needs were similar during both waves. High-flow oxygen ( n = 5, 2%), noninvasive ventilation [CPAP ( n = 34, 16%) and BiPAP ( n = 8, 5%)] and invasive ventilation ( n = 45, 21%) were respiratory support therapies needed. NIV use was more during the second wave (26% vs. 13%; p = 0.02). The median (IQR) length (days) of DCH stay among survivors was longer during the first wave [8 (6–10) vs. 5.5 (3–8); p = 0.0001]. Conclusions Disease severity, associated comorbidities, PICU and organ support need and mortality were similar in the first and second waves of the pandemic. Children admitted during the second wave were younger, had higher proportion of NIV use and shorter length of COVID-19 hospital stay. Supplementary Information The online version contains supplementary material available at 10.1007/s12098-022-04283-0.

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Multisystem inflammatory syndrome in children – A serious emerging syndrome

Nazareth,

Tauro

2024

Muller Journal of Medical Sciences and Research

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Objective: The objective of the study was to determine the clinical features, treatment received, and outcomes of severely ill children with multisystem inflammatory syndrome in children (MIS-C). Methods: The study was a retrospective observation carried out at a pediatric intensive care unit in a tertiary care hospital. The baseline history, investigations, treatment received, and outcomes of the disease in 14 critically ill children, who were diagnosed with MIS-C, were surveyed from October 2020 to January 2022. Results: There were 14 children who were diagnosed with MIS-C. All children received intensive care treatment and 7 children received a combination of steroid therapy and intravenous immunoglobulin. Out of 14 children, 12 of them survived and 2 expired. Conclusion: For children who are diagnosed with MIS-C, the outcome was good if detected early and treated on time.

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Clinical and laboratory profile of children with COVID-19 admitted at a tertiary care hospital in Karnataka, Southern India

Cited by 3 publications

References 16 publications

Clinical profile of Covid-19 in children: Study from a Medical College Hospital in Mangalore, Karnataka, India

Clinical profile of Covid-19 in children: Study from a Medical College Hospital in Mangalore, Karnataka, India

Epidemiology, Clinical Profile, Intensive Care Needs and Outcome in Children with SARS-CoV-2 Infection Admitted to a Tertiary Hospital During the First and Second Waves of the COVID-19 Pandemic in India

Multisystem inflammatory syndrome in children – A serious emerging syndrome

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