Clinical and laboratory profiles of refractory Mycoplasma pneumoniae pneumonia in children

Wang, Meijuan; Wang, Yuqing; Ya, Yan; Zhu, Canhong; Huang, Li; Shao, Xuejun; Xu, Jun; Zhu, Hong; Sun, Xiang; Ji, Wei; Chen, Zhengrong

doi:10.1016/j.ijid.2014.07.020

Cited by 113 publications

(110 citation statements)

References 34 publications

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“…However, longer duration of fever, longer length of stay, and higher incidence of extra-pulmonary complications were found in the RMPP group than those in the GMPP group, which indicated that to some extent children with RMPP had a more severe illness. With respect to radiological findings, pleural effusion and large lesions were more frequently found in the RMPP group than those in the GMPP group, which were similar to previous reports816.…”

Section: Discussionsupporting

confidence: 91%

“…In our other study, we found that the incidence of RMPP in school-aged children was more common than younger children (data not published). Some studies816 also found that children with RMPP were significant older (the mean age was 66.6~73.2 months) than children with GMPP. So age should be one of confounders of some clinical presentation and biological markers because children were in the process of growing.…”

Section: Discussionmentioning

confidence: 95%

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Cytokines as the good predictors of refractory Mycoplasma pneumoniae pneumonia in school-aged children

Zhang

Mei

Zhou

et al. 2016

Sci Rep

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Excessive immune response against pathogens may play an important role in refracory Mycoplasma pneumoniae pneumonia (RMPP). The aim of this study was to elucidate the associations between cytokines and the prediction of RMPP in school-aged patients. Retrospective analysis was performed on school-aged children with Mycoplasma pneumoniae pneumonia (MPP) hospitalized in our hospital between January 1, 2011 and December 31, 2015. The clinical charcteristics, including the cytokines in serum between the RMPP group and the general Mycoplasma pneumoniae pneumonia (GMPP) group were compared and the predictive values of RMPP were explored. Of total 180 patients, 115 patients were in the GMPP group, 65 were in the RMPP group. We found the levels of cytokines, including nterleukin (IL)-6, IL-10, interferon gamma (IFN-γ) in RMPP group were significantly higher than those in GMPP group (P < 0.01). In ROC curve analysis, IL-10 and IFN-γ were useful for differentiating patients with RMPP from those with GMPP. Logistic regression analysis showed that the IL-10 ≥ 3.65 pg/ml and IFN-γ ≥ 29.05 pg/ml were significant predictors regarding to RMPP. Additionally, a positive correlation between serum IL-10 and IFN-γ concentrations was observed. Conclusions: IL-10 and IFN-γ could be used as the good predictors of RMPP in school-aged children.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 95%

Cytokines as the good predictors of refractory Mycoplasma pneumoniae pneumonia in school-aged children

Zhang

Mei

Zhou

et al. 2016

Sci Rep

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“…La mayoría de las infecciones por M. pneumoniae generalmente son leves y auto limitadas; sin embargo, en la actualidad se reconoce que puede ocasionar cuadros graves y refractarios como neumonía fulminante, neumonía necrotizante y desarrollo del síndrome de dificultad respiratoria del adulto (SDRA). 51 También se ha asociado a otras infecciones del tracto respiratorio superior como: faringitis, bronquitis, laringotraqueítis, rinosinusitis, otitis media, miringitis y bronquiolitis. 52 Además, causa una gran variedad de infecciones extrapulmonares que afectan prácticamente a cualquier órgano.…”

Section: Manifestaciones Clínicasunclassified

“…61 También se ha encontrado que en cuadros más graves y refractarios se observan más las consolidaciones segmentaria-lobar (50-62%), así como incremento en el derrame pleural hasta el 22%. 51 …”

Section: Estudios De Imagenunclassified

“…9 No obstante, si se ha reportado elevación de la proteína C reactiva en cuadros refractarios. 51 Algunos estudios han demostrado también que la BH no tiene diferencias significativas en comparación con neumonías ocasionadas por otros patógenos. 34 Un hallazgo relevante es que se ha documentado que la elevación de la deshidrogenasa láctica (DHL) puede ser un biomarcador predictivo de la gravedad de la neumonía por M. pneumoniae, ya que en pacientes tanto pediátricos como adultos los niveles de DHL se correlacionan con el desarrollo de neumonía fulminante.…”

Section: Biometría Hemáticaunclassified

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Cambiando los paradigmas de la infección por M. pneumoniae en pediatría

et al. 2017

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CorrespondenciaDe Colsa-Ranero A agustin.decolsa@infecto.mx Este artículo debe citarse comoMerida-Vieyra J, Aquino-Andrade A, Ribas-Aparicio RM, De Colsa-Ranero A. Cambiando los paradigmas de la infección por M. pneumoniae en pediatría. Acta Pediatr Mex. 2017;38(6):412-426. ResumenLa neumonía atípica es un término que originalmente se utilizó en pacientes adultos que presentaban neumonías de curso atípico, generalmente leves y de evolución benigna, que eran causadas por agentes como: Mycoplasma pneumoniae, Chlamydophila pneumoniae y Legionella pneumophila.En población pediátrica la presentación, tanto clínica como epidemiológica, de las neumonías por M. pneumoniae merece una especial atención ya que no siempre son cursos benignos y pueden existir numerosos cuadros extrapulmonares asociados; el proceso diagnóstico es complejo y poco diferencial de otros agentes etiológicos.Recientemente ha llamado la atención la emergencia de la resistencia a macrólidos en algunos países del mundo, por lo que existen controversias respecto al tratamiento. Estudios numerosos realizados a nivel mundial, particularmente derivados de países asiáticos, han generado nueva información en relación al comportamiento biológico, clínico, epidemiológico, radiológico y respuesta terapéutica de M. pneumoniae en pacientes pediátricos. PALABRAS CLAVE:Mycoplasma pneumoniae, pacientes pediátricos, neumonía, diagnóstico. Changing the paradigms of M. pneumoniae infection in pediatrics.Acta Pediatr Mex. 2017 Nov;38 (6) AbstractAtypical pneumonia is a term that was used originally in adult patients who had atypical pneumonia symptoms, usually with mild and benign courses, and were caused by agents such as Mycoplasma pneumoniae, Chlamydophila pneumoniae and Legionella pneumophila. In pediatric patients, the clinical and epidemiological aspects of M. pneumoniae www.actapediatrica.org.mx

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Integration of lipidomics and metabolomics reveals plasma and urinary profiles associated with pediatric Mycoplasma pneumoniae infections and its severity

Chen,

et al. 2023

Biomedical Chromatography

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Mycoplasma pneumoniae is a significant contributor to lower respiratory infections in children. However, the lipidomics and metabolics bases of childhood M. pneumoniae infections remain unclear. In this study, lipidomics and metabolomics analyses were conducted using UHPLC‐LTQ‐Orbitrap XL mass spectrometry and gas chromatography‐triple quadrupole mass spectrometry on plasma (n = 65) and urine (n = 65) samples. MS‐DIAL software, in combination with LipidBlast and Fiehn BinBase DB, identified 163 lipids and 104 metabolites in plasma samples, as well as 208 metabolites in urine samples. Perturbed lipid species (adjusted p < 0.05) were observed, including lysophosphatidylethanolamines, phosphatidylinositols, phosphatidylcholines, phosphatidylethanol amines, and triglycerides. Additionally, differential metabolites (adjusted p < 0.05) exhibited associations with amino acid metabolism, nucleotide metabolism, and energy metabolism. Thirteen plasma metabolites, namely l‐hydroxyproline, 3‐phosphoglycerate, citric acid, creatine, inosine, ribitol, α tocopherol, cholesterol, cystine, serine, uric acid, tagatose, and glycine, showed significant associations with disease severity (p < 0.05) and exhibited distinct separation patterns in M. pneumoniae–infected bronchitis and pneumonia, with an area under the curve of 0.927. Nine of them exhibited either positive or negative correlations with neutrophil or lymphocyte percentages. These findings indicated significant systemic metabolic shifts in childhood M. pneumoniae infections, offering valuable insights into the associated metabolic alterations and their relationship with disease severity.

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Clinical and laboratory profiles of refractory Mycoplasma pneumoniae pneumonia in children

Abstract: This study indicates that a direct microbe effect and the subsequent induced excessive host immune response contribute in part to the progression of RMPP.

Cited by 113 publications

References 34 publications

Cytokines as the good predictors of refractory Mycoplasma pneumoniae pneumonia in school-aged children

Cytokines as the good predictors of refractory Mycoplasma pneumoniae pneumonia in school-aged children

Cambiando los paradigmas de la infección por M. pneumoniae en pediatría

Integration of lipidomics and metabolomics reveals plasma and urinary profiles associated with pediatric Mycoplasma pneumoniae infections and its severity

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