Clinical and Laboratory Studies of Liver Function in Therapeutic Malaria*

Glenn, Paul M.; Kaplan, Lawrence I.; Read, Hilton S.; Becker, Frederic T.

doi:10.1097/00000441-194621220-00010

Cited by 2 publications

(2 citation statements)

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“…It is recognized that hippuric acid synthesis is impaired in certain types of liver disorder as first suggested by Quick (36) and confirmed by others (37)(38)(39). According to Snapper and his associates (40)(41)(42) the decreased hippuric acid synthesis is balanced, at least in part, by increased excretion of benzoyl glucuronate.…”

Section: Resultsmentioning

confidence: 90%

Urinary Excretion of Amino Acids in Liver Disease 1

Dunn¹,

Akawaie²,

Yeh³

et al. 1950

J. Clin. Invest.

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Previous studies from the authors' laboratories have established the range of values for the urinary excretion of 15 amino acids by normal males and females (1, 2). A preliminary survey of the urinary excretion of tryptophane, histidine, and cystine in a variety of disease states, including liver disease, showed that almost one-half of the values were either higher or lower than those observed in the control series (3). Because of the abnormalities encountered in this study, and the known relationship of the liver to amino acid metabolism (4-6), further investigation has been made into the urinary excretion of amino acids in liver disease. The present report is a study of the urinary excretion of amino acids by 25 patients, the majority of whom had subacute or chronic cirrhosis. METHODSThe previously described methods (1-3, 7, 8) were employed for the preparation of the urine samples and the determination of amino acids by microbiological assay. The probable accuracy of the amino acid data is indicated by average deviations from the mean which averaged 5 (3.7-6.7) per cent for the values at the different levels of the samples. The serum albumin and globulin fractions and total protein were performed by the methods of Kingsley (9); the blood non-protein-nitrogen by the method of Peters and Van Slyke (10); the carbon dioxide combining power by the method of Van Slyke, Stillman, and Cullen (11); the blood sugar by the method of Benedict (12), and the prothrombin time by the Quick method (13). RESULTS

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Section: Resultsmentioning

confidence: 90%

Urinary Excretion of Amino Acids in Liver Disease 1

Dunn¹,

Akawaie²,

Yeh³

et al. 1950

J. Clin. Invest.

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show abstract

“…University of Virginia Hospital, Charlottesville, Va.) (Received for publication April 1, 1948) Abnormal liver function has been reported in malaria (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11), and in infectious mononucleosis (12), and its occurrence has been mentioned in pneumonia (13). Wade and Richmann (14) considered the possible influence of non-specific fever on the cephalin-cholesterol flocculation test, and Machella (15) has reported bromsulfalein retention during fever following foreign protein injection.…”

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confidence: 99%