The article provides an overview of the conceptual studies of modern digital technologies for the fabrication of complete removable acrylic dentures. Analysis of the presented data of subtractive and additive methods of digital manufacturing shows the indisputable advantages of digital CAD/CAM-methods of manufacturing in comparison with traditional methods. Use of known pre-polymerized acrylic blocks in subtractive milling method has allowed to achieve high physical and mechanical properties, optimal spatial accuracy and minimal thickness of the fabricated dentures. Moreover, the reduction of residual monomer volume in solid polymer blocks has allowed to achieve high biological inertness and safety of the fabricated structures for prosthetic bed tissues and the patient's body as a whole. Layer-by-layer printing method of removable dentures by fused polymer deposition modeling technology is characterized by high spatial accuracy of constructing structures of any degree of complexity and reduction of the total production time of removable dentures. In spite of the intensity of implementation of digital CAD/CAM-technologies process in the practice of complete removable dentures manufacturing, the search for alternative methods of modernization of the known traditional means and methods is still continuing. However, in our opinion, the process of automation and digitalization of the clinical and laboratory manufacturing of complete removable acrylic dentures has clear prospects for the total replacement of compression pressing and hot polymerization techniques of acrylates. In summary, the potential prospect for the near future is a global reassessment of traditional concepts for the fabrication of complete removable dentures, taking into account the formation of an innovative digital CAD/CAM-philosophy and the introduction of computer intelligent systems.