Clinical and laboratory variables of childhood systemic lupus erythematosus in western province of Saudi Arabia

Muzaffer, Mohammed; Al‐Mayouf, Sulaiman M.

doi:10.1007/s00296-009-1210-2

Cited by 13 publications

(23 citation statements)

References 17 publications

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“…We found that the mean age of our patients was 11.5 years, our result was comparable to those found by Taddio (14) found by Muzaffer et al [9][10][11]13,20] (Table 5). This fluctuation of results could be due to the range of age.…”

Section: Discussionsupporting

confidence: 91%

“…In our study, the frequency of renal disease (73%) was similar to that found by Yalaoui et al (75%) who had studied childhood SLE in the north of Tunisia and by Muzaffer et al (73.3%) [12,14], but a lower frequency has been found in other series [9,20]. As it has been found in other series of childhood SLE, the class IV lupus nephritis (53.8%) was the most frequent one in our patients with proteuniria and who underwent renal biopsy [13,15].…”

Section: Present Study (N=37)supporting

confidence: 90%

“…This difference could be explained, partly, by the fact that the results of other series (33.3%, 23%, 11.1%) found by Muzaffer et al, Hiraki et al and Taddio et al respectively [9,10,13] incorporate hemolytic anemia while our results include all types of anemia observed in the SLE, whether hemolytic or inflammatory.…”

Section: Present Study (N=37)contrasting

confidence: 63%

“…This fluctuation of results could be due to the range of age. In fact, the range in our study was 9 months to 15 years, but it was 5 to 18 years in Muzaffer's study [13]. The youngest patient of our series who is also the youngest one in all the other series of SLE is 9 months old.…”

Section: Discussioncontrasting

confidence: 52%

“…It has been suggested that children with SLE had different signs and symptoms at onset and a more severe and aggressive disease course than adult patients [6][7][8]. Many investigators have described the features of childhood SLE among different ethnic groups [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The aim of our retrospective study was to determine the clinical and serological characteristics of childhood SLE in the center of Tunisia.…”

Section: Introductionmentioning

confidence: 99%

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Systemic Lupus Erythematosus in Children: A Study about 37 Tunisian Cases

W¹

2014

J Clin Cell Immunol

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Aim: To determine the clinical and serological characteristics in pediatric systemic lupus erythematosus (SLE). Patients and methods:This retrospective study included 37 patients with SLE. All patients fulfilled the ACR revised criteria for SLE and diagnosed between 1994 and 2009. Anti-nuclear antibodies were detected by indirect immunofluorescence (IIF) on liver rat sections. Anti-dsDNA, anti-Sm, anti-nucleosome, anti-SSA, anti-SSB and anti-RNP antibodies were detected by ELISA. Anti-dsDNA antibodies were detected also by IIF on Chrithidia luciliae. Results:The most common signs were anemia (86.5%), proteinuria (73%) and malar rash (67.6%). The frequency of arthritis and photosensitivity were 45.9% and 43.2% respectively. Leucopenia, thrombocytopenia and oral ulcer were present in 37.8%, 32.4% and 18.9% of cases respectively. The frequency of discoid rash was 13.5%. Anti-dsDNA antibodies were detected in 81.1%, anti-Sm and anti-RNP in 56.8%, anti-SSA in 43.2% and anti-SSB in 35.1%. Conclusion:The highest frequency of childhood SLE is situated at the age of puberty. Renal disease is very frequent in paediatric SLE.

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Section: Discussionsupporting

confidence: 91%

Section: Present Study (N=37)supporting

confidence: 90%

Section: Present Study (N=37)contrasting

confidence: 63%

Section: Discussioncontrasting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

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Systemic Lupus Erythematosus in Children: A Study about 37 Tunisian Cases

W¹

2014

J Clin Cell Immunol

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Prevalence and Patterns of Renal Involvement Among Patients With Systemic Lupus Erythematous at a Tertiary Center

Hasan¹,

Alali

Alsadah

et al. 2022

J Clin Rheumatol

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BackgroundSystemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by widespread inflammation and damage to multiple organ systems. One of the most common and severe manifestations of SLE is lupus nephritis (LN).ObjectivesTo determine the prevalence of LN among subjects with SLE and to identify the demographic, clinical, and laboratory parameters of SLE in subjects diagnosed with LN.MethodsThis is a descriptive study conducted at a tertiary hospital. Medical records were reviewed from outpatients who visited between January 2015 and October 2019 and who has fulfilled the classification criteria for diagnosis of SLE and had LN.ResultsAmong 365 patients with SLE, 36% had LN. The most prevalent World Health Organization class of LN was IV, which significantly correlated with both abnormal creatinine levels and nephrotic range proteinuria. Elevated serum creatinine correlated with the presence of hypertension and thrombocytopenia. Cutaneous manifestations were noted to be present in 100% of LN patients, followed by arthritis and/or arthralgia (82.9%), anemia (94.6%), and lymphopenia (87.6%).ConclusionThis study aids in the recognition of the demographic, clinical, laboratory features, and the histological patterns of LN patients in Saudi Arabia, that probably has a role in the development and disease progression. A significant correlation was found between abnormal kidney function and hypertension, thrombocytopenia and nephrotic range proteinuria. The presence of World Health Organization class IV LN correlated with both impaired kidney function and nephrotic range proteinuria.

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